ID   X5E1M5_STAAU            Unreviewed;        63 AA.
AC   X5E1M5; A0A1E8XDA6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   02-APR-2025, entry version 80.
DE   SubName: Full=Membrane protein {ECO:0000313|EMBL:KMR37018.1};
DE   SubName: Full=Peptide resistance ABC transporter activity modulator VraH {ECO:0000313|EMBL:MVK35436.1};
GN   Name=vraH {ECO:0000313|EMBL:MVK35436.1};
GN   ORFNames=ACR79_10280 {ECO:0000313|EMBL:KSA79803.1}, CNH36_15160
GN   {ECO:0000313|EMBL:ATC72896.1}, E1948_00075
GN   {ECO:0000313|EMBL:QCT55926.1}, E1948_10970
GN   {ECO:0000313|EMBL:MBX8595114.1}, EIH03_04305
GN   {ECO:0000313|EMBL:RZI07873.1}, EP54_05485
GN   {ECO:0000313|EMBL:KMR57599.1}, EQ90_05885
GN   {ECO:0000313|EMBL:KMR37018.1}, ERS391062_00871
GN   {ECO:0000313|EMBL:CZQ57664.1}, GF599_01790
GN   {ECO:0000313|EMBL:MRV46307.1}, GO814_09835
GN   {ECO:0000313|EMBL:MVK35436.1}, GO942_12135
GN   {ECO:0000313|EMBL:MVM11413.1}, SAMEA1466929_01269
GN   {ECO:0000313|EMBL:SRC24525.1};
OS   Staphylococcus aureus.
OC   Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:MVK35436.1, ECO:0000313|Proteomes:UP000471199};
RN   [1] {ECO:0000313|EMBL:KMR37018.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA15 {ECO:0000313|EMBL:KMR37018.1}, and M121
RC   {ECO:0000313|EMBL:KMR57599.1};
RX   PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA   Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G.,
RA   Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J.,
RA   Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M.,
RA   Robinson D.A., Arias C.A.;
RT   "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus USA300 Infection in North and South America.";
RL   J. Infect. Dis. 212:1874-1882(2015).
RN   [2] {ECO:0000313|EMBL:KSA79803.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MRSA_S26 {ECO:0000313|EMBL:KSA79803.1};
RA   Diene S.M., Von Dach E., Fankhauser C., Schrenzel J., Harbarth S.,
RA   Francois P.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KSA79803.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MRSA_S26 {ECO:0000313|EMBL:KSA79803.1};
RX   PubMed=26464204;
RA   Von Dach E., Diene S.M., Fankhauser C., Schrenzel J., Harbarth S.,
RA   Francois P.;
RT   "Comparative Genomics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva,
RT   Switzerland.";
RL   J. Infect. Dis. 0:0-0(2016).
RN   [4] {ECO:0000313|EMBL:CZQ57664.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1943STDY5698364 {ECO:0000313|EMBL:CZQ57664.1};
RG   Pathogen Informatics;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ATC72896.1, ECO:0000313|Proteomes:UP000217245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman {ECO:0000313|Proteomes:UP000217245}, and Newman_D2C
RC   {ECO:0000313|EMBL:ATC72896.1};
RA   Copin R.J., Sause W., Shopsin B., Torres V.J.;
RT   "A single nucleotide polymorphism in the Staphylococcus aureus virulence
RT   regulator SaeR abolishes pathogenesis.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:MRV46307.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UA905 {ECO:0000313|EMBL:MRV46307.1};
RX   PubMed=29977970;
RA   Miller W.R., Seas C., Carvajal L.P., Diaz L., Echeverri A.M., Ferro C.,
RA   Rios R., Porras P., Luna C., Gotuzzo E., Munita J.M., Nannini E.,
RA   Carcamo C., Reyes J., Arias C.A.;
RT   "The Cefazolin Inoculum Effect Is Associated With Increased Mortality in
RT   Methicillin-Susceptible Staphylococcus aureus Bacteremia.";
RL   Open Forum Infect. Dis. 5:0-ofy123(2018).
RN   [7] {ECO:0000313|EMBL:SRC24525.1, ECO:0000313|Proteomes:UP000249918}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EOE047 {ECO:0000313|EMBL:SRC24525.1,
RC   ECO:0000313|Proteomes:UP000249918};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:RZI07873.1, ECO:0000313|Proteomes:UP000294017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA12 {ECO:0000313|EMBL:RZI07873.1,
RC   ECO:0000313|Proteomes:UP000294017};
RA   Amoako D.G., Somboro A.M., Abia A.L.K., Bester L.A., Essack S.Y.;
RT   "Genomic profiling of Staphylococcus species from a Poultry farm system in
RT   KwaZulu-Natal, South Africa.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:QCT55926.1, ECO:0000313|Proteomes:UP000309390}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lr2 {ECO:0000313|EMBL:QCT55926.1,
RC   ECO:0000313|Proteomes:UP000309390};
RA   Ullah N., Ali A.;
RT   "Whole-genome sequencing of local methicillin-resistant S. aureus strain
RT   Lr2.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000471199, ECO:0000313|Proteomes:UP000478867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM11413.1,
RC   ECO:0000313|Proteomes:UP000478867}, and S_2062.LAUP.DI
RC   {ECO:0000313|EMBL:MVK35436.1, ECO:0000313|Proteomes:UP000471199};
RA   Stine O.C.;
RT   "Implementation of targeted gown and glove precautions to prevent
RT   Staphylococcus aureus acquisition in community-based nursing homes.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:MRV46307.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UA905 {ECO:0000313|EMBL:MRV46307.1};
RA   Arias C.A., Diaz L.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:MBX8595114.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lr2 {ECO:0000313|EMBL:MBX8595114.1};
RA   Ali A., Ullah N.;
RT   "Whole-genome sequencing of local methicillin-resistant S. aureus strain
RT   Lr2.";
RL   Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP023391; ATC72896.1; -; Genomic_DNA.
DR   EMBL; FJNR01000004; CZQ57664.1; -; Genomic_DNA.
DR   EMBL; LALJ01000007; KMR37018.1; -; Genomic_DNA.
DR   EMBL; LALQ01000017; KMR57599.1; -; Genomic_DNA.
DR   EMBL; LFVP01000006; KSA79803.1; -; Genomic_DNA.
DR   EMBL; JAIGOF010000015; MBX8595114.1; -; Genomic_DNA.
DR   EMBL; WKIH01000004; MRV46307.1; -; Genomic_DNA.
DR   EMBL; WPTS01000027; MVK35436.1; -; Genomic_DNA.
DR   EMBL; WPXC01000030; MVM11413.1; -; Genomic_DNA.
DR   EMBL; CP038850; QCT55926.1; -; Genomic_DNA.
DR   EMBL; RQTF01000062; RZI07873.1; -; Genomic_DNA.
DR   EMBL; UDJK01000004; SRC24525.1; -; Genomic_DNA.
DR   RefSeq; WP_000672039.1; NZ_WWFR01000002.1.
DR   Proteomes; UP000052129; Unassembled WGS sequence.
DR   Proteomes; UP000070985; Unassembled WGS sequence.
DR   Proteomes; UP000217245; Chromosome.
DR   Proteomes; UP000249918; Unassembled WGS sequence.
DR   Proteomes; UP000294017; Unassembled WGS sequence.
DR   Proteomes; UP000309390; Unassembled WGS sequence.
DR   Proteomes; UP000447638; Unassembled WGS sequence.
DR   Proteomes; UP000471199; Unassembled WGS sequence.
DR   Proteomes; UP000478867; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR049869; VraH.
DR   NCBIfam; NF033835; VraH_fam; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   63 AA;  7195 MW;  450014CAABDA1BED CRC64;
     MKFRELVKQS YEDLKNLTVT WYNVIALTIL VIVLSSFTTP MIGIPAGLLG GSYYLKRREE
     KGK
//