ID X2JIZ6_DROME Unreviewed; 1173 AA. AC X2JIZ6; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 10-FEB-2021, entry version 61. DE SubName: Full=Stardust, isoform P {ECO:0000313|EMBL:AHN59482.1}; DE EC=2.7.4.8 {ECO:0000313|EMBL:AHN59482.1}; GN Name=sdt {ECO:0000313|EMBL:AHN59482.1, GN ECO:0000313|FlyBase:FBgn0261873}; GN Synonyms=anon-EST:fe2E6 {ECO:0000313|EMBL:AHN59482.1}, BP1063 GN {ECO:0000313|EMBL:AHN59482.1}, CG12657 {ECO:0000313|EMBL:AHN59482.1}, GN CG12658 {ECO:0000313|EMBL:AHN59482.1}, CG15339 GN {ECO:0000313|EMBL:AHN59482.1}, CG15340 {ECO:0000313|EMBL:AHN59482.1}, GN CG15341 {ECO:0000313|EMBL:AHN59482.1}, CG15342 GN {ECO:0000313|EMBL:AHN59482.1}, CG1617 {ECO:0000313|EMBL:AHN59482.1}, GN cGUK1 {ECO:0000313|EMBL:AHN59482.1}, cMAGUK1 GN {ECO:0000313|EMBL:AHN59482.1}, Dmel\CG32717 GN {ECO:0000313|EMBL:AHN59482.1}, l(1)7Ef {ECO:0000313|EMBL:AHN59482.1}, GN pal1 {ECO:0000313|EMBL:AHN59482.1}, PALS1 GN {ECO:0000313|EMBL:AHN59482.1}, Pals1 {ECO:0000313|EMBL:AHN59482.1}, GN SDT {ECO:0000313|EMBL:AHN59482.1}, Sdt {ECO:0000313|EMBL:AHN59482.1}, GN Std {ECO:0000313|EMBL:AHN59482.1}, std {ECO:0000313|EMBL:AHN59482.1}; GN ORFNames=CG32717 {ECO:0000313|EMBL:AHN59482.1, GN ECO:0000313|FlyBase:FBgn0261873}, Dmel_CG32717 GN {ECO:0000313|EMBL:AHN59482.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the MAGUK family. CC {ECO:0000256|ARBA:ARBA00007014}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AHN59482.1; -; Genomic_DNA. DR RefSeq; NP_001285011.1; NM_001298082.1. DR SMR; X2JIZ6; -. DR EnsemblMetazoa; FBtr0340142; FBpp0309128; FBgn0261873. DR GeneID; 44861; -. DR CTD; 44861; -. DR FlyBase; FBgn0261873; sdt. DR GeneTree; ENSGT00940000156087; -. DR BioGRID-ORCS; 44861; 0 hits in 1 CRISPR screen. DR ChiTaRS; sdt; fly. DR GenomeRNAi; 44861; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0261873; Expressed in saliva-secreting gland and 43 other tissues. DR ExpressionAtlas; X2JIZ6; baseline and differential. DR GO; GO:0045179; C:apical cortex; IDA:FlyBase. DR GO; GO:0016324; C:apical plasma membrane; IDA:FlyBase. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:FlyBase. DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-KW. DR GO; GO:0005918; C:septate junction; TAS:FlyBase. DR GO; GO:0035003; C:subapical complex; IPI:FlyBase. DR GO; GO:0004385; F:guanylate kinase activity; ISS:FlyBase. DR GO; GO:0045176; P:apical protein localization; IMP:FlyBase. DR GO; GO:0070830; P:bicellular tight junction assembly; IEA:InterPro. DR GO; GO:0007043; P:cell-cell junction assembly; NAS:FlyBase. DR GO; GO:0040003; P:chitin-based cuticle development; IMP:FlyBase. DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro. DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:FlyBase. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:FlyBase. DR GO; GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase. DR GO; GO:0002009; P:morphogenesis of an epithelium; NAS:FlyBase. DR GO; GO:0042461; P:photoreceptor cell development; IMP:FlyBase. DR GO; GO:0045186; P:zonula adherens assembly; IMP:FlyBase. DR CDD; cd12036; SH3_MPP5; 1. DR Gene3D; 2.30.42.10; -; 2. DR InterPro; IPR008145; GK/Ca_channel_bsu. DR InterPro; IPR008144; Guanylate_kin-like_dom. DR InterPro; IPR020590; Guanylate_kinase_CS. DR InterPro; IPR014775; L27_C. DR InterPro; IPR004172; L27_dom. DR InterPro; IPR031185; MPP5-like. DR InterPro; IPR035601; MPP5_SH3. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23122:SF14; PTHR23122:SF14; 1. DR Pfam; PF00625; Guanylate_kin; 1. DR Pfam; PF02828; L27; 1. DR Pfam; PF00595; PDZ; 2. DR Pfam; PF07653; SH3_2; 1. DR SMART; SM00072; GuKc; 1. DR SMART; SM00228; PDZ; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR SUPFAM; SSF50156; SSF50156; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1. DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1. DR PROSITE; PS51022; L27; 1. DR PROSITE; PS50106; PDZ; 2. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0000213|PeptideAtlas:X2JIZ6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}; KW Transferase {ECO:0000313|EMBL:AHN59482.1}. FT DOMAIN 54..103 FT /note="PDZ" FT /evidence="ECO:0000259|PROSITE:PS50106" FT DOMAIN 568..624 FT /note="L27" FT /evidence="ECO:0000259|PROSITE:PS51022" FT DOMAIN 717..796 FT /note="PDZ" FT /evidence="ECO:0000259|PROSITE:PS50106" FT DOMAIN 822..893 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 972..1152 FT /note="Guanylate kinase-like" FT /evidence="ECO:0000259|PROSITE:PS50052" FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 340..409 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 618..638 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 428..448 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 1137..1157 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 345..362 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 394..409 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1173 AA; 129070 MW; 876827F2D8D6A158 CRC64; MQANSSRSNL SAQSSGTPSA STISSSQGKQ QVVELSGYVI ILVENVEGKI KLYGSPPDRD NLEVGDEILE VNGLTLENIS RTEVIRHIHD CIKSCTICLR VRKKNDSRLA WDIGNSVQDA FVIAVEEHAR ERLQRLAALN RVTPVDITQL SKKLLEDVIV HQASDVHSYS TSASAAAIAS SSNRSQQQQQ QQQQHQLLSA AYELQQQQQL QLQQQQQQQN SPTSSISIGR TELLLGDQSL RQDPRGNRRR SGSSIVVLDG DDLKPCLPDD YISGQHHLNH QQQLQLQQQL QQQHPLQQQH YRTHSGDIRE IDQEMLTMLS VNQDNGPHRE MAVDCPDTFI ARNKTPPRYP PPRPPQLNGN AKPVPPPRDH LRVEKDGRLV NCSPAPQLPD RRAPGNASSG SSGATTHPLQ HQQIAQIVEP TLEQLDSIKK YQEQLRRRRE EEERIAQQNE FLRNSLRGSR KLKALQDTAT PGKAVAQQQQ QATLATQVVG VENEAYLPDE DQPQAEQIDG YGELIAALTR LQNQLSKSGL STLAGRVSAA HSVLASASVA HVLAARTAVL QRRRSRVSGP LHHSSLGLQK DIVELLTQSN TAAAIELGNL LTSHEMEGLL LAHDRIANHT DGTPSPTPTP TPAIGAATGS TLSSPVAGPK RNLGMVVPPP VVPPPLAQRG AMPLPRGESP PPVPMPPLAT MPMSMPVNLP MSACFGTLND QNDNIRIIQI EKSTEPLGAT VRNEGEAVVI GRIVRGGAAE KSGLLHEGDE ILEVNGQELR GKTVNEVCAL LGAMQGTLTF LIVPAGSPPS VGVMGGTTGS QLAGLGGAHR DTAVLHVRAH FDYDPEDDLY IPCRELGISF QKGDVLHVIS REDPNWWQAY REGEEDQTLA GLIPSQSFQH QRETMKLAIA EEAGLARSRG KDGSGSKGAT LLCARKGRKK KKKASSEAGY PLYATTAPDE TDPEEILTYE EVALYYPRAT HKRPIVLIGP PNIGRHELRQ RLMADSERFS AAVPHTSRAR REGEVPGVDY HFITRQAFEA DILARRFVEH GEYEKAYYGT SLEAIRTVVA SGKICVLNLH PQSLKLLRAS DLKPYVVLVA PPSLDKLRQK KLRNGEPFKE EELKDIIATA RDMEARWGHL FDMIIINNDT ERAYHQLLAE INSLEREPQW VPAQWVHNNR DES //