ID X2JIZ6_DROME Unreviewed; 1173 AA. AC X2JIZ6; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 18-JAN-2017, entry version 27. DE SubName: Full=Stardust, isoform P {ECO:0000313|EMBL:AHN59482.1}; DE EC=2.7.4.8 {ECO:0000313|EMBL:AHN59482.1}; GN Name=sdt {ECO:0000313|EMBL:AHN59482.1, GN ECO:0000313|FlyBase:FBgn0261873}; GN ORFNames=CG32717 {ECO:0000313|FlyBase:FBgn0261873}, Dmel_CG32717 GN {ECO:0000313|EMBL:AHN59482.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN59482.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Contains 2 PDZ (DHR) domains. CC {ECO:0000256|RuleBase:RU003354}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AHN59482.1; -; Genomic_DNA. DR RefSeq; NP_001285011.1; NM_001298082.1. DR UniGene; Dm.17605; -. DR ProteinModelPortal; X2JIZ6; -. DR SMR; X2JIZ6; -. DR STRING; 7227.FBpp0111740; -. DR PaxDb; X2JIZ6; -. DR EnsemblMetazoa; FBtr0340142; FBpp0309128; FBgn0261873. DR GeneID; 44861; -. DR CTD; 44861; -. DR FlyBase; FBgn0261873; sdt. DR eggNOG; KOG0609; Eukaryota. DR eggNOG; COG0194; LUCA. DR GeneTree; ENSGT00760000118866; -. DR OrthoDB; EOG091G065I; -. DR ChiTaRS; sdt; fly. DR GenomeRNAi; 44861; -. DR Proteomes; UP000000803; Chromosome X. DR ExpressionAtlas; X2JIZ6; differential. DR GO; GO:0005912; C:adherens junction; IDA:FlyBase. DR GO; GO:0045179; C:apical cortex; IDA:FlyBase. DR GO; GO:0016324; C:apical plasma membrane; IDA:FlyBase. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:FlyBase. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005918; C:septate junction; TAS:FlyBase. DR GO; GO:0035003; C:subapical complex; IPI:FlyBase. DR GO; GO:0004385; F:guanylate kinase activity; ISS:FlyBase. DR GO; GO:0045176; P:apical protein localization; IMP:FlyBase. DR GO; GO:0070830; P:bicellular tight junction assembly; IEA:InterPro. DR GO; GO:0007043; P:cell-cell junction assembly; NAS:FlyBase. DR GO; GO:0040003; P:chitin-based cuticle development; IMP:FlyBase. DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro. DR GO; GO:0007163; P:establishment or maintenance of cell polarity; NAS:FlyBase. DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:FlyBase. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:FlyBase. DR GO; GO:0046331; P:lateral inhibition; IMP:FlyBase. DR GO; GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase. DR GO; GO:0002009; P:morphogenesis of an epithelium; NAS:FlyBase. DR GO; GO:0042461; P:photoreceptor cell development; IMP:FlyBase. DR GO; GO:0045186; P:zonula adherens assembly; IMP:FlyBase. DR Gene3D; 2.30.42.10; -; 2. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR008145; GK/Ca_channel_bsu. DR InterPro; IPR008144; Guanylate_kin-like_dom. DR InterPro; IPR020590; Guanylate_kinase_CS. DR InterPro; IPR014775; L27_C. DR InterPro; IPR004172; L27_dom. DR InterPro; IPR031185; MPP5. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001478; PDZ. DR InterPro; IPR011511; SH3_2. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23122:SF14; PTHR23122:SF14; 3. DR Pfam; PF00625; Guanylate_kin; 1. DR Pfam; PF02828; L27; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF07653; SH3_2; 1. DR SMART; SM00072; GuKc; 1. DR SMART; SM00228; PDZ; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR SUPFAM; SSF50156; SSF50156; 2. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1. DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1. DR PROSITE; PS51022; L27; 1. DR PROSITE; PS50106; PDZ; 2. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:X2JIZ6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW SH3 domain {ECO:0000256|SAAS:SAAS00071823}; KW Transferase {ECO:0000313|EMBL:AHN59482.1}. FT DOMAIN 54 103 PDZ (DHR). {ECO:0000259|PROSITE:PS50106}. FT DOMAIN 568 624 L27. {ECO:0000259|PROSITE:PS51022}. FT DOMAIN 717 796 PDZ (DHR). {ECO:0000259|PROSITE:PS50106}. FT DOMAIN 822 893 SH3. {ECO:0000259|PROSITE:PS50002}. FT DOMAIN 972 1152 Guanylate kinase-like. FT {ECO:0000259|PROSITE:PS50052}. SQ SEQUENCE 1173 AA; 129070 MW; 876827F2D8D6A158 CRC64; MQANSSRSNL SAQSSGTPSA STISSSQGKQ QVVELSGYVI ILVENVEGKI KLYGSPPDRD NLEVGDEILE VNGLTLENIS RTEVIRHIHD CIKSCTICLR VRKKNDSRLA WDIGNSVQDA FVIAVEEHAR ERLQRLAALN RVTPVDITQL SKKLLEDVIV HQASDVHSYS TSASAAAIAS SSNRSQQQQQ QQQQHQLLSA AYELQQQQQL QLQQQQQQQN SPTSSISIGR TELLLGDQSL RQDPRGNRRR SGSSIVVLDG DDLKPCLPDD YISGQHHLNH QQQLQLQQQL QQQHPLQQQH YRTHSGDIRE IDQEMLTMLS VNQDNGPHRE MAVDCPDTFI ARNKTPPRYP PPRPPQLNGN AKPVPPPRDH LRVEKDGRLV NCSPAPQLPD RRAPGNASSG SSGATTHPLQ HQQIAQIVEP TLEQLDSIKK YQEQLRRRRE EEERIAQQNE FLRNSLRGSR KLKALQDTAT PGKAVAQQQQ QATLATQVVG VENEAYLPDE DQPQAEQIDG YGELIAALTR LQNQLSKSGL STLAGRVSAA HSVLASASVA HVLAARTAVL QRRRSRVSGP LHHSSLGLQK DIVELLTQSN TAAAIELGNL LTSHEMEGLL LAHDRIANHT DGTPSPTPTP TPAIGAATGS TLSSPVAGPK RNLGMVVPPP VVPPPLAQRG AMPLPRGESP PPVPMPPLAT MPMSMPVNLP MSACFGTLND QNDNIRIIQI EKSTEPLGAT VRNEGEAVVI GRIVRGGAAE KSGLLHEGDE ILEVNGQELR GKTVNEVCAL LGAMQGTLTF LIVPAGSPPS VGVMGGTTGS QLAGLGGAHR DTAVLHVRAH FDYDPEDDLY IPCRELGISF QKGDVLHVIS REDPNWWQAY REGEEDQTLA GLIPSQSFQH QRETMKLAIA EEAGLARSRG KDGSGSKGAT LLCARKGRKK KKKASSEAGY PLYATTAPDE TDPEEILTYE EVALYYPRAT HKRPIVLIGP PNIGRHELRQ RLMADSERFS AAVPHTSRAR REGEVPGVDY HFITRQAFEA DILARRFVEH GEYEKAYYGT SLEAIRTVVA SGKICVLNLH PQSLKLLRAS DLKPYVVLVA PPSLDKLRQK KLRNGEPFKE EELKDIIATA RDMEARWGHL FDMIIINNDT ERAYHQLLAE INSLEREPQW VPAQWVHNNR DES //