ID X2JEQ0_DROME Unreviewed; 1651 AA. AC X2JEQ0; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 13-SEP-2023, entry version 65. DE SubName: Full=Radish, isoform K {ECO:0000313|EMBL:AHN59648.1}; GN Name=rsh {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}; GN Synonyms=CG15720 {ECO:0000313|EMBL:AHN59648.1}, CG18646 GN {ECO:0000313|EMBL:AHN59648.1}, CG42628 {ECO:0000313|EMBL:AHN59648.1}, GN CG42629 {ECO:0000313|EMBL:AHN59648.1}, CG4346 GN {ECO:0000313|EMBL:AHN59648.1}, CG4368 {ECO:0000313|EMBL:AHN59648.1}, GN Dmel\CG44424 {ECO:0000313|EMBL:AHN59648.1}, FBpp0073550 GN {ECO:0000313|EMBL:AHN59648.1}, R5_X:12971309..12973132 GN {ECO:0000313|EMBL:AHN59648.1}, Rad {ECO:0000313|EMBL:AHN59648.1}, rad GN {ECO:0000313|EMBL:AHN59648.1}, Rsh {ECO:0000313|EMBL:AHN59648.1}; GN ORFNames=CG44424 {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}, Dmel_CG44424 GN {ECO:0000313|EMBL:AHN59648.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AHN59648.1; -; Genomic_DNA. DR RefSeq; NP_001285178.1; NM_001298249.1. DR SMR; X2JEQ0; -. DR EnsemblMetazoa; FBtr0340352; FBpp0309310; FBgn0265597. DR GeneID; 32253; -. DR AGR; FB:FBgn0265597; -. DR CTD; 32253; -. DR FlyBase; FBgn0265597; rsh. DR VEuPathDB; VectorBase:FBgn0265597; -. DR OrthoDB; 25782at2759; -. DR BioGRID-ORCS; 32253; 0 hits in 1 CRISPR screen. DR ChiTaRS; pins; fly. DR GenomeRNAi; 32253; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0265597; Expressed in brain and 4 other tissues. DR ExpressionAtlas; X2JEQ0; baseline and differential. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase. DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central. DR GO; GO:0007615; P:anesthesia-resistant memory; IDA:FlyBase. DR GO; GO:0008355; P:olfactory learning; TAS:FlyBase. DR GO; GO:0008016; P:regulation of heart contraction; IMP:FlyBase. DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. DR CDD; cd08368; LIM; 1. DR Gene3D; 6.10.140.210; -; 1. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1. DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR035974; Rap/Ran-GAP_sf. DR InterPro; IPR000331; Rap/Ran_GAP_dom. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR PANTHER; PTHR15711:SF25; RADISH, ISOFORM I; 1. DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1. DR Pfam; PF00651; BTB; 1. DR Pfam; PF02145; Rap_GAP; 1. DR SMART; SM00225; BTB; 1. DR SUPFAM; SSF54695; POZ domain; 1. DR SUPFAM; SSF111347; Rap/Ran-GAP; 1. DR PROSITE; PS50085; RAPGAP; 1. PE 4: Predicted; KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 863..1081 FT /note="Rap-GAP" FT /evidence="ECO:0000259|PROSITE:PS50085" FT REGION 66..97 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 111..202 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 232..509 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 731..750 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1209..1238 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1260..1297 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1541..1560 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1607..1651 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 111..138 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 150..169 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 181..202 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 236..255 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 285..354 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 355..370 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 408..455 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 456..504 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1209..1235 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1267..1295 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1637..1651 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1651 AA; 186493 MW; 9C8C91206C3605F2 CRC64; MSKLRHYRSM DQPCSSTCVV IRKKTMTAIC FVCNLPIMSH QVGLVWQGGN GWDDLVREQL EESTIRQRLG GRRDSAAQIT TPPSTSPPPG LQRRRRSSLA QLTDILREWS GGTKQQQQHH SQQQQQQLQQ ASRSKAQLNR RETLADLARS LPWRTSTTTD ASTGAGGSGG GGCTTYMAPR KRRESSADSG IRSMRSRRDS NTAEFVRHWN RRESGAVEEQ PSVSVPVVVE CSKSASRRGS GESYLSSSRR DSNVAGRVTT PPPPGKYQMT KKRDSLAAPE FPNFRQEQRP STSSAGSCSD HSMPLISTHS STHHLAHQQV DSACQALPPP TIITSSVTPP ATSPTAPKGR RDSQTQCGRV NRRDSKAGVS PERAPRLQRL QRQATAFDEG CLPGGSRRGS QPALSPDPPD DCERRTSRRD SLSPDSASRG GRRDSRTHLS PDRSHERDGS PRRHTLRRQS SSAARSPRSP DSNSCCSSRD PSPCSRPQTQ TTVEQNQRPA IRRQSTTEEI LIARGFRRQS TTEEMIRCRN FRRQSSQSDD VCRYRGRRDS SAQIIDGTIG TMTVETTSTF FDSSTQTEPS PLYDNNHYHE ECLRCNSCGL NLTGPNQKRA RRFKNQILCD LHFADVALME CSDFMQQLRS FKPQSLGCAV ARRKSSTTLI FPLPPQACSD EFCEEYPHNL MPTPGYWIEC SRQKITMPTP HTIWDESDSE HEDIRAGSAS DAYLERECSD LYEDDEDSEA TPSPRKKTTI EEQWDQQGAF ELISVEQETY EKYFYGTEHW NYFTSDEDLG PVILSIKQET LNGRDQFRIL VRAGSYTVHG LIPASCVFAD RYNREEVVRS LGKEVNLNPP LTLGQLPDTP EELLKLDQVF IKSELKVGVI FVKEDQYTEE QILDNNENSP LFDEFLTLLG DRVRLRGFDK YKGGLDTVHD LTGLFSVYTN WRNIEIMFHV STLLPYEKHD PQKLQRKRHI GNDIVCVVFL EADNTRFSPA CIKSHFLHTF ILVRVSARIK HKPTRYEVSV VTRDEVGAYK PYLWEQSVFE KGPMFREWLL TKIVNGERAS YSAPKFARMQ ERTRSQMLED LVMNLSNHAE TGQIPKPYRR GSWRPIGHMR PSSPLLDSVR DQFEDYDQLA KDFTRVFLNE EPSCLTNAHL FDVVFLVGQS KQKARFIGVR AILGVRSRVF QEMLYGIQTG FGSPQIPVAE IFARPAPSLV SPQNQKPKSN NYLTVPDSDS IRPKSVPSSP MVKRAFSRLG TITAGWGRSI RNKNTNQLNP DDKKKWISST DYRDSKDKDK DKPGNNQLAV PRLSVCADAQ KVDRAKLAQT EFNIIEFDPD TFRVLLDYLH TGTCPLTCVS IPGLLCAAEH YDLPELLQAC FHHCKQFLRI EVVCPMLISL ENYYWRYTSA SELVNMILSF VESKAHSLFK CPEFLHLSES MVQMIMCREL QTPEIRKFEA MLAWAQHKVG KLKNHPNKDT QFEFECIMER LTRDLNLCRI SPSELLTVVL PSKSMKNERI METLMVQVNL GTYRMPELDA YRQQLRQQES AEATVQVHRA HQNHHNPPPI DARAYAMASL AAALEMQNSS NPLQSNAARD AADEEVELYA SFDNAPSTSR VAAQMQAAKE ARRKRWAADG ASGSSGDGGC ASGSSGSGRR Y //