ID X2JEQ0_DROME Unreviewed; 1651 AA. AC X2JEQ0; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 31-JUL-2019, entry version 50. DE SubName: Full=Radish, isoform K {ECO:0000313|EMBL:AHN59648.1}; GN Name=rad {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}; GN Synonyms=CG15720 {ECO:0000313|EMBL:AHN59648.1}, CG18646 GN {ECO:0000313|EMBL:AHN59648.1}, CG42628 {ECO:0000313|EMBL:AHN59648.1}, GN CG42629 {ECO:0000313|EMBL:AHN59648.1}, CG4346 GN {ECO:0000313|EMBL:AHN59648.1}, CG4368 {ECO:0000313|EMBL:AHN59648.1}, GN Dmel\CG44424 {ECO:0000313|EMBL:AHN59648.1}, FBpp0073550 GN {ECO:0000313|EMBL:AHN59648.1}, R5_X:12971309..12973132 GN {ECO:0000313|EMBL:AHN59648.1}, Rad {ECO:0000313|EMBL:AHN59648.1}, Rsh GN {ECO:0000313|EMBL:AHN59648.1}, rsh {ECO:0000313|EMBL:AHN59648.1}; GN ORFNames=CG44424 {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}, Dmel_CG44424 GN {ECO:0000313|EMBL:AHN59648.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AHN59648.1; -; Genomic_DNA. DR RefSeq; NP_001285178.1; NM_001298249.1. DR SMR; X2JEQ0; -. DR PaxDb; X2JEQ0; -. DR EnsemblMetazoa; FBtr0340352; FBpp0309310; FBgn0265597. DR GeneID; 32253; -. DR CTD; 32253; -. DR FlyBase; FBgn0265597; rad. DR eggNOG; ENOG410IJXG; Eukaryota. DR eggNOG; ENOG410Z9ZH; LUCA. DR ChiTaRS; pins; fly. DR GenomeRNAi; 32253; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0265597; Expressed in 6 organ(s), highest expression level in head. DR ExpressionAtlas; X2JEQ0; differential. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase. DR GO; GO:0007615; P:anesthesia-resistant memory; IDA:FlyBase. DR GO; GO:0008355; P:olfactory learning; TAS:FlyBase. DR GO; GO:0008016; P:regulation of heart contraction; IMP:FlyBase. DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.11210; -; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR035974; Rap/Ran-GAP_sf. DR InterPro; IPR000331; Rap_GAP_dom. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR Pfam; PF00651; BTB; 1. DR Pfam; PF02145; Rap_GAP; 1. DR SMART; SM00225; BTB; 1. DR SUPFAM; SSF111347; SSF111347; 1. DR SUPFAM; SSF54695; SSF54695; 1. DR PROSITE; PS50085; RAPGAP; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 863 1081 Rap-GAP. {ECO:0000259|PROSITE:PS50085}. FT REGION 66 97 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 111 202 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 232 509 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 731 750 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1209 1238 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1260 1297 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1541 1560 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1607 1651 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 111 138 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 150 169 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 181 202 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 236 255 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 285 354 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 355 370 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 408 455 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 456 504 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 1209 1235 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 1267 1295 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 1637 1651 Polar. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 1651 AA; 186493 MW; 9C8C91206C3605F2 CRC64; MSKLRHYRSM DQPCSSTCVV IRKKTMTAIC FVCNLPIMSH QVGLVWQGGN GWDDLVREQL EESTIRQRLG GRRDSAAQIT TPPSTSPPPG LQRRRRSSLA QLTDILREWS GGTKQQQQHH SQQQQQQLQQ ASRSKAQLNR RETLADLARS LPWRTSTTTD ASTGAGGSGG GGCTTYMAPR KRRESSADSG IRSMRSRRDS NTAEFVRHWN RRESGAVEEQ PSVSVPVVVE CSKSASRRGS GESYLSSSRR DSNVAGRVTT PPPPGKYQMT KKRDSLAAPE FPNFRQEQRP STSSAGSCSD HSMPLISTHS STHHLAHQQV DSACQALPPP TIITSSVTPP ATSPTAPKGR RDSQTQCGRV NRRDSKAGVS PERAPRLQRL QRQATAFDEG CLPGGSRRGS QPALSPDPPD DCERRTSRRD SLSPDSASRG GRRDSRTHLS PDRSHERDGS PRRHTLRRQS SSAARSPRSP DSNSCCSSRD PSPCSRPQTQ TTVEQNQRPA IRRQSTTEEI LIARGFRRQS TTEEMIRCRN FRRQSSQSDD VCRYRGRRDS SAQIIDGTIG TMTVETTSTF FDSSTQTEPS PLYDNNHYHE ECLRCNSCGL NLTGPNQKRA RRFKNQILCD LHFADVALME CSDFMQQLRS FKPQSLGCAV ARRKSSTTLI FPLPPQACSD EFCEEYPHNL MPTPGYWIEC SRQKITMPTP HTIWDESDSE HEDIRAGSAS DAYLERECSD LYEDDEDSEA TPSPRKKTTI EEQWDQQGAF ELISVEQETY EKYFYGTEHW NYFTSDEDLG PVILSIKQET LNGRDQFRIL VRAGSYTVHG LIPASCVFAD RYNREEVVRS LGKEVNLNPP LTLGQLPDTP EELLKLDQVF IKSELKVGVI FVKEDQYTEE QILDNNENSP LFDEFLTLLG DRVRLRGFDK YKGGLDTVHD LTGLFSVYTN WRNIEIMFHV STLLPYEKHD PQKLQRKRHI GNDIVCVVFL EADNTRFSPA CIKSHFLHTF ILVRVSARIK HKPTRYEVSV VTRDEVGAYK PYLWEQSVFE KGPMFREWLL TKIVNGERAS YSAPKFARMQ ERTRSQMLED LVMNLSNHAE TGQIPKPYRR GSWRPIGHMR PSSPLLDSVR DQFEDYDQLA KDFTRVFLNE EPSCLTNAHL FDVVFLVGQS KQKARFIGVR AILGVRSRVF QEMLYGIQTG FGSPQIPVAE IFARPAPSLV SPQNQKPKSN NYLTVPDSDS IRPKSVPSSP MVKRAFSRLG TITAGWGRSI RNKNTNQLNP DDKKKWISST DYRDSKDKDK DKPGNNQLAV PRLSVCADAQ KVDRAKLAQT EFNIIEFDPD TFRVLLDYLH TGTCPLTCVS IPGLLCAAEH YDLPELLQAC FHHCKQFLRI EVVCPMLISL ENYYWRYTSA SELVNMILSF VESKAHSLFK CPEFLHLSES MVQMIMCREL QTPEIRKFEA MLAWAQHKVG KLKNHPNKDT QFEFECIMER LTRDLNLCRI SPSELLTVVL PSKSMKNERI METLMVQVNL GTYRMPELDA YRQQLRQQES AEATVQVHRA HQNHHNPPPI DARAYAMASL AAALEMQNSS NPLQSNAARD AADEEVELYA SFDNAPSTSR VAAQMQAAKE ARRKRWAADG ASGSSGDGGC ASGSSGSGRR Y //