ID X2JEQ0_DROME Unreviewed; 1651 AA. AC X2JEQ0; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 07-NOV-2018, entry version 43. DE SubName: Full=Radish, isoform K {ECO:0000313|EMBL:AHN59648.1}; GN Name=rad {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}; GN Synonyms=CG15720 {ECO:0000313|EMBL:AHN59648.1}, CG18646 GN {ECO:0000313|EMBL:AHN59648.1}, CG42628 {ECO:0000313|EMBL:AHN59648.1}, GN CG42629 {ECO:0000313|EMBL:AHN59648.1}, CG4346 GN {ECO:0000313|EMBL:AHN59648.1}, CG4368 {ECO:0000313|EMBL:AHN59648.1}, GN Dmel\CG44424 {ECO:0000313|EMBL:AHN59648.1}, FBpp0073550 GN {ECO:0000313|EMBL:AHN59648.1}, R5_X:12971309..12973132 GN {ECO:0000313|EMBL:AHN59648.1}, Rad {ECO:0000313|EMBL:AHN59648.1}, rsh GN {ECO:0000313|EMBL:AHN59648.1}; GN ORFNames=CG44424 {ECO:0000313|EMBL:AHN59648.1, GN ECO:0000313|FlyBase:FBgn0265597}, Dmel_CG44424 GN {ECO:0000313|EMBL:AHN59648.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AHN59648.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AHN59648.1; -; Genomic_DNA. DR RefSeq; NP_001285178.1; NM_001298249.1. DR SMR; X2JEQ0; -. DR STRING; 7227.FBpp0301611; -. DR PaxDb; X2JEQ0; -. DR EnsemblMetazoa; FBtr0340352; FBpp0309310; FBgn0265597. DR GeneID; 32253; -. DR CTD; 32253; -. DR FlyBase; FBgn0265597; rad. DR eggNOG; ENOG410IJXG; Eukaryota. DR eggNOG; ENOG410Z9ZH; LUCA. DR GeneTree; ENSGT00760000119182; -. DR OrthoDB; EOG091G01GV; -. DR Reactome; R-DME-392517; Rap1 signalling. DR ChiTaRS; pins; fly. DR GenomeRNAi; 32253; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0265597; Expressed in 6 organ(s), highest expression level in head. DR ExpressionAtlas; X2JEQ0; baseline and differential. DR GO; GO:0030424; C:axon; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005096; F:GTPase activator activity; ISS:FlyBase. DR GO; GO:0007615; P:anesthesia-resistant memory; IDA:FlyBase. DR GO; GO:0008355; P:olfactory learning; TAS:FlyBase. DR GO; GO:0008016; P:regulation of heart contraction; IMP:FlyBase. DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. DR Gene3D; 3.40.50.11210; -; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR035974; Rap/Ran-GAP_sf. DR InterPro; IPR000331; Rap_GAP_dom. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR Pfam; PF00651; BTB; 1. DR Pfam; PF02145; Rap_GAP; 1. DR SMART; SM00225; BTB; 1. DR SUPFAM; SSF111347; SSF111347; 1. DR SUPFAM; SSF54695; SSF54695; 1. DR PROSITE; PS50085; RAPGAP; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 863 1081 Rap-GAP. {ECO:0000259|PROSITE:PS50085}. FT COILED 121 141 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1651 AA; 186493 MW; 9C8C91206C3605F2 CRC64; MSKLRHYRSM DQPCSSTCVV IRKKTMTAIC FVCNLPIMSH QVGLVWQGGN GWDDLVREQL EESTIRQRLG GRRDSAAQIT TPPSTSPPPG LQRRRRSSLA QLTDILREWS GGTKQQQQHH SQQQQQQLQQ ASRSKAQLNR RETLADLARS LPWRTSTTTD ASTGAGGSGG GGCTTYMAPR KRRESSADSG IRSMRSRRDS NTAEFVRHWN RRESGAVEEQ PSVSVPVVVE CSKSASRRGS GESYLSSSRR DSNVAGRVTT PPPPGKYQMT KKRDSLAAPE FPNFRQEQRP STSSAGSCSD HSMPLISTHS STHHLAHQQV DSACQALPPP TIITSSVTPP ATSPTAPKGR RDSQTQCGRV NRRDSKAGVS PERAPRLQRL QRQATAFDEG CLPGGSRRGS QPALSPDPPD DCERRTSRRD SLSPDSASRG GRRDSRTHLS PDRSHERDGS PRRHTLRRQS SSAARSPRSP DSNSCCSSRD PSPCSRPQTQ TTVEQNQRPA IRRQSTTEEI LIARGFRRQS TTEEMIRCRN FRRQSSQSDD VCRYRGRRDS SAQIIDGTIG TMTVETTSTF FDSSTQTEPS PLYDNNHYHE ECLRCNSCGL NLTGPNQKRA RRFKNQILCD LHFADVALME CSDFMQQLRS FKPQSLGCAV ARRKSSTTLI FPLPPQACSD EFCEEYPHNL MPTPGYWIEC SRQKITMPTP HTIWDESDSE HEDIRAGSAS DAYLERECSD LYEDDEDSEA TPSPRKKTTI EEQWDQQGAF ELISVEQETY EKYFYGTEHW NYFTSDEDLG PVILSIKQET LNGRDQFRIL VRAGSYTVHG LIPASCVFAD RYNREEVVRS LGKEVNLNPP LTLGQLPDTP EELLKLDQVF IKSELKVGVI FVKEDQYTEE QILDNNENSP LFDEFLTLLG DRVRLRGFDK YKGGLDTVHD LTGLFSVYTN WRNIEIMFHV STLLPYEKHD PQKLQRKRHI GNDIVCVVFL EADNTRFSPA CIKSHFLHTF ILVRVSARIK HKPTRYEVSV VTRDEVGAYK PYLWEQSVFE KGPMFREWLL TKIVNGERAS YSAPKFARMQ ERTRSQMLED LVMNLSNHAE TGQIPKPYRR GSWRPIGHMR PSSPLLDSVR DQFEDYDQLA KDFTRVFLNE EPSCLTNAHL FDVVFLVGQS KQKARFIGVR AILGVRSRVF QEMLYGIQTG FGSPQIPVAE IFARPAPSLV SPQNQKPKSN NYLTVPDSDS IRPKSVPSSP MVKRAFSRLG TITAGWGRSI RNKNTNQLNP DDKKKWISST DYRDSKDKDK DKPGNNQLAV PRLSVCADAQ KVDRAKLAQT EFNIIEFDPD TFRVLLDYLH TGTCPLTCVS IPGLLCAAEH YDLPELLQAC FHHCKQFLRI EVVCPMLISL ENYYWRYTSA SELVNMILSF VESKAHSLFK CPEFLHLSES MVQMIMCREL QTPEIRKFEA MLAWAQHKVG KLKNHPNKDT QFEFECIMER LTRDLNLCRI SPSELLTVVL PSKSMKNERI METLMVQVNL GTYRMPELDA YRQQLRQQES AEATVQVHRA HQNHHNPPPI DARAYAMASL AAALEMQNSS NPLQSNAARD AADEEVELYA SFDNAPSTSR VAAQMQAAKE ARRKRWAADG ASGSSGDGGC ASGSSGSGRR Y //