ID X2FCQ4_CHV16 Unreviewed; 1240 AA. AC X2FCQ4; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 16-MAR-2016, entry version 10. DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442}; DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442}; GN Name=UL30 {ECO:0000313|EMBL:AHM96079.1}; OS Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. OX NCBI_TaxID=340907 {ECO:0000313|EMBL:AHM96079.1}; OH NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OH NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque). OH NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque). OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=90387; Macaca leonina (Northern pig-tailed macaque) (Macaca nemestrina leonina). RN [1] {ECO:0000313|EMBL:AHM96079.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=OU1-76 {ECO:0000313|EMBL:AHM96079.1}; RX PubMed=24606686; DOI=10.1016/j.virol.2013.12.038; RA Black D., Ohsawa K., Tyler S., Maxwell L., Eberle R.; RT "A single viral gene determines lethal cross-species neurovirulence of RT baboon herpesvirus HVP2."; RL Virology 452-453:86-94(2014). CC -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = CC diphosphate + DNA(n+1). {ECO:0000256|RuleBase:RU000442}. CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. CC {ECO:0000256|RuleBase:RU000442}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF908240; AHM96079.1; -; Genomic_DNA. DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR Gene3D; 3.30.420.10; -; 1. DR Gene3D; 3.90.1600.10; -; 2. DR InterPro; IPR006172; DNA-dir_DNA_pol_B. DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS. DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc. DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom. DR InterPro; IPR023211; DNA_pol_palm_dom. DR InterPro; IPR021639; DNAPolymera_Pol_C. DR InterPro; IPR012337; RNaseH-like_dom. DR Pfam; PF00136; DNA_pol_B; 1. DR Pfam; PF03104; DNA_pol_B_exo1; 1. DR Pfam; PF11590; DNAPolymera_Pol; 1. DR PRINTS; PR00106; DNAPOLB. DR SMART; SM00486; POLBc; 1. DR SUPFAM; SSF53098; SSF53098; 2. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. PE 3: Inferred from homology; KW DNA replication {ECO:0000256|RuleBase:RU000442}; KW DNA-binding {ECO:0000256|RuleBase:RU000442}; KW DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442}; KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442, KW ECO:0000313|EMBL:AHM96079.1}; KW Transferase {ECO:0000256|RuleBase:RU000442, KW ECO:0000313|EMBL:AHM96079.1}. FT DOMAIN 188 543 DNA_pol_B_exo1. {ECO:0000259|Pfam: FT PF03104}. FT DOMAIN 616 1199 DNA_pol_B. {ECO:0000259|Pfam:PF00136}. FT DOMAIN 1205 1240 DNAPolymera_Pol. {ECO:0000259|Pfam: FT PF11590}. SQ SEQUENCE 1240 AA; 135777 MW; 4F0A1484582626F6 CRC64; MGPVGRGGPG AGAAARAAAA GFFGPPAGRG SAPPPRPREN FYNPYLAAGR RSGAAGRGAQ PAPHSYCSEC DEFRFVAPRA LDEDAAPEMR VGVHDGRLRR APRVYCGGEE RDVLDFGRDA FWPRRARLWA GVDRAPAEAA PPVDLFHVYD IVENVEHAQH GGCAGRTHGR FLDAITPSGT VVTLLGLTPE GRRVAVHVYG TRQYFYMNRA EVDRRLGCRA PRDLCERMAT ALRESPGGSF RNISADHFEV DVVDRADVYY YETPRVPYYR VYARNGRALA YLCDNFCPGI RKYEGGVDAT TRFVLDNPGF VTFGWYRLGP GRDGAPPHPR PAEAFVTSSD VEVDCTADNL AVERERGDLP GYKLMCFDIE CKAGGEDEAA FPVAANAEDL VIQISCLLYD LAAARLEHIL LFSLGSCDLP EAFVADLGAR GLPAPTVLEF DSEFEMLLAF VTFVKQYGPE FATGYNIINF DWPFLIAKLT DVYKVPLDGY GRMNRRGVFR VWDIGQSHFQ KRSKIKMNGV VNIDMYGIVC DKVKLSSYKL NAVAEAVLKD KKKDLSYRDI PRYYAAGPAQ RGVIGEYCVQ DSLLVGQLFF KFLPHLELSA VARLAGITLT RTIYDGQQIR VYTCLLRLAG QKGFLLPDNP GRFAGAAAAR AGGDGGQEEE DAAGAEEDGG GADAGEGGGD EDASGGGAEP AAREGGAGRH VGYQGAKVLD PASGFHVDPV VVFDFASLYP SIIQAHNLCF STLSLSADAV AGLEPERDYL AIEVGGRRLF FVKAHVRESL LSILLRDWLA MRKQIRSRIP HSAPEEAVLL DKQQAAIKVV CNSVYGFTGV QHGLLPCLHV AATVTTIGRD MLLATREYVH ARWTTFDRLE ADFPEAATMR APGPFSMRII YGDTDSIFVL SRGLTAEGLT AMGDRMAAHI SRALFPPPIK LECEKTFAKL LLIAKKKYIG VICGGKMLIK GVDLVRKNNC AFINRTSRAL VDLLFYDDAV SAAAAALAAR PPEEWLAHPL PEGLDAFGRV LVDAHRRITD PDRDVRDFVL TSELSRHPRA YANKRLPHLT VYYKLLARRD QVPSIKDRIP YVIVAQTREV EETVARIDAL RELDAAPPAP PEPPPPPASA PAPPKRPRGR HPGDPEPKRR RLLVSELAED PAHAVAHRVP LNTDYYFSHL LGAACVTFKA LFGNNAKITE NLLKRFIPEV WHPEEETAVR LRAAGFRAAG AGATEAETRR RLRTAFDILA //