ID X2DR70_9INFA Unreviewed; 757 AA. AC X2DR70; DT 11-JUN-2014, integrated into UniProtKB/TrEMBL. DT 11-JUN-2014, sequence version 1. DT 10-MAY-2017, entry version 18. DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00377010}; DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU004330, ECO:0000256|SAAS:SAAS00376969}; GN Name=PB1 {ECO:0000313|EMBL:AHL81439.1}; OS Influenza A virus (A/Tennessee/F1080/2010(H1N1)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1452594 {ECO:0000313|EMBL:AHL81439.1, ECO:0000313|Proteomes:UP000115638}; RN [1] {ECO:0000313|EMBL:AHL81439.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/Tennessee/F1080/2010 {ECO:0000313|EMBL:AHL81439.1}; RA Wentworth D.E., Halpin R.A., Lin X., Bera J., Ransier A., Fedorova N., RA Tsitrin T., McLellan M., Stockwell T., Amedeo P., Appalla L., RA Bishop B., Edworthy P., Gupta N., Hoover J., Katzel D., Li K., RA Schobel S., Shrivastava S., Thovarai V., Wang S., Oshansky C.M., RA Wong S.S., Webby R., Bao Y., Sanders R., Zhdanov S., Kiryutin B., RA Lipman D.J., Tatusova T., Thomas P.G.; RT "The NIAID Influenza Genome Sequencing Project."; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AHL81439.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/Tennessee/F1080/2010 {ECO:0000313|EMBL:AHL81439.1}; RG The NIAID Influenza Genome Sequencing Consortium; RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|RuleBase:RU004330, CC ECO:0000256|SAAS:SAAS00605060}. CC -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1 CC family. {ECO:0000256|SAAS:SAAS00565435}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY167786; AHL81439.1; -; Viral_cRNA. DR Proteomes; UP000115638; Genome. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR InterPro; IPR007099; RNA-dir_pol_NSvirus. DR InterPro; IPR001407; RNA_pol_PB1_influenza. DR Pfam; PF00602; Flu_PB1; 1. DR PIRSF; PIRSF000827; RdRPol_OMV; 1. DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000115638}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00605058}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00605055}; KW RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004330, KW ECO:0000256|SAAS:SAAS00605053}; KW Transferase {ECO:0000256|SAAS:SAAS00605061}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00605045}. FT DOMAIN 286 483 RdRp catalytic. {ECO:0000259|PROSITE: FT PS50525}. SQ SEQUENCE 757 AA; 86323 MW; E99C4D5A768A9223 CRC64; MDVNPTLLFL KIPAQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEVVQQTRVD KLTQGRQTYD WTLNRNQPAA TALANTIEVF RSNGLTANES GRLIDFLKDV MESMNKEEIE ITTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLNKRGYLIR ALTLNTMTKD AERGKLKRRA IATPGMQIRG FVYFVETLAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTEISF TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNILSMA PIMFSNKMAR LGKGYMFESK RMKIRTQIPA EMLASIDLKY FNESTKKKIE KIRPLLIDGT ASLSPGMMMG MFNMLSTVLG VSILNLGQKK YTKTIYWWDG LQSSDDFALI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK KSYINKTGTF EFTSFFYRYG FVANFSMELP SFGVSGVNES ADMSIGVTVI KNNMINNDLG PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRSFELKKLW DQTQSKVGLL VSDGGPNLYN IRNLHIPEVC LKWELMDDDY RGRLCNPLNP FVSHKEIDSV NNAVVMPAHG PAKSMEYDAV ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS RARIDARVDF ESGRIGKEEF SEIMKICSTI EELRRQK //