ID   X1WN16_ACYPI            Unreviewed;       845 AA.
AC   X1WN16;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   12-APR-2017, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:ACYPI062391-PA};
OS   Acyrthosiphon pisum (Pea aphid).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha;
OC   Aphidomorpha; Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon.
OX   NCBI_TaxID=7029 {ECO:0000313|EnsemblMetazoa:ACYPI062391-PA, ECO:0000313|Proteomes:UP000007819};
RN   [1] {ECO:0000313|EnsemblMetazoa:ACYPI062391-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LSR1 {ECO:0000313|EnsemblMetazoa:ACYPI062391-PA};
RA   Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S.,
RA   Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V.,
RA   Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A.,
RA   Cardenas V., Carter K., Chacko J., Chandrabose M.N., Chavez D.,
RA   Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M.,
RA   Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B.,
RA   Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E.,
RA   Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S.,
RA   Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A.,
RA   Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E.,
RA   Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E.,
RA   Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N.,
RA   Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A.,
RA   Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J.,
RA   Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R.,
RA   Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C.,
RA   Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T.,
RA   Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B.,
RA   Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B.,
RA   Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G.,
RA   Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C.,
RA   Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J.,
RA   Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J.,
RA   Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E.,
RA   Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D.,
RA   Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L.,
RA   Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K.,
RA   Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W.,
RA   Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G.,
RA   Gibbs R.A.;
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACYPI062391-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABLF02028257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003247427.1; XM_003247379.3.
DR   UniGene; Aps.104147; -.
DR   UniGene; Aps.66324; -.
DR   EnsemblMetazoa; ACYPI062391-RA; ACYPI062391-PA; ACYPI062391.
DR   GeneID; 100166223; -.
DR   KEGG; api:100166223; -.
DR   KO; K06704; -.
DR   PhylomeDB; X1WN16; -.
DR   Proteomes; UP000007819; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR027053; ADAM_10.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   PANTHER; PTHR11905:SF184; PTHR11905:SF184; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007819};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00473808};
KW   Membrane {ECO:0000256|SAAS:SAAS00781307, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007819};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00781291,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00781361,
KW   ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    845       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004947994.
FT   TRANSMEM    734    757       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      243    483       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      500    606       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   ACT_SITE    430    430       {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT   METAL       429    429       Zinc; catalytic. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00276}.
FT   METAL       433    433       Zinc; catalytic. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00276}.
FT   METAL       439    439       Zinc; catalytic. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00276}.
SQ   SEQUENCE   845 AA;  95137 MW;  78D37B9AAA8A47DF CRC64;
     MYTLSYSAVV LLIITSNIQG KRLSQYVSHY EPVTYDHQHL AQSHDRAKRS VTNSDSNVHV
     TFKAHGHHFR LRLRRDVETF SNAMEVLDSF GNQIHPSSID TSHIYHGHIV DEANSIVFGS
     ITDGVFEGQI ISPKKGNYFI EKSRKYIYPH GHLNDSDNFH SVIYKENDVD NPYHNSSSHF
     SGCGVTGSTK QSMETIQYSG SPWNIQQQDE ERPAYKYTRQ AADKHHHGPV RTKRATKPKE
     ERNTCSLFIQ TDPLLWKHIK EQDGYDKTKT REEILSLIAH HVTAVNYIYR DTKFDGRIEH
     RNIKFEVQRI KIDDDEPCDH KWTGEQNPFC MENIDVSNFL NLHSLGNHED FCLAYVFTYR
     DFTGGTLRSS LVASASGASG GICEKYKTYT ETIGGLYQST KRSLNTGIIT FVNYNSRVPP
     KVSQLTLAHE IGHNFGSPHD YPSDCRPGGL SGNYIMFASA TSGDRPNNSK FSSCSIANIS
     SVLDAIQDNK KRNCFKASEG AFCGNKIVEN GEECDCGYDD DECDDKCCYP RQVADRDRFR
     NISARGCARR AQTECSPSQG PCCYADTCRF IPSNRQVMCR GEDVCSYSSN CDGTSPECPV
     PPPKPNKTRC NEGTQLCING DCTGSICLEW GLNECFLTSQ IIPNIDKRKL CELACMNGTD
     LQTCRSTSEF AAAVNLPLGG ISLRPGSPCD NFQGYCDVFY KCRAVDAEGP LARLKNMLLN
     KQTLQTLQQW ALENWWACML MGVTFVIIMG VFIKCCAVHT PSSNPKKTPA RRFSETLRRP
     ITTLRRMRNN PQTYVSQPRS SRVPAHGYGE GRGHYYAPRA SAPPAHGHSD RRNAFPMRHQ
     PQHKV
//