ID X1WG47_DANRE Unreviewed; 196 AA. AC X1WG47; A0A8M1N312; DT 14-MAY-2014, integrated into UniProtKB/TrEMBL. DT 14-MAY-2014, sequence version 1. DT 24-JAN-2024, entry version 45. DE SubName: Full=Interleukin 12a {ECO:0000313|Ensembl:ENSDARP00000129202, ECO:0000313|RefSeq:NP_001007108.2}; GN Name=IL-12 p35 {ECO:0000313|RefSeq:NP_001007108.2}; GN Synonyms=IL-12p35 {ECO:0000313|RefSeq:NP_001007108.2}; GN OrderedLocusNames=il12a {ECO:0000313|Ensembl:ENSDARP00000129202, GN ECO:0000313|RefSeq:NP_001007108.2, GN ECO:0000313|ZFIN:ZDB-GENE-060724-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129202}; RN [1] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=16614377; DOI=10.1677/joe.1.06591; RA Huising M.O., Kruiswijk C.P., Flik G.; RT "Phylogeny and evolution of class-I helical cytokines."; RL J. Endocrinol. 189:1-25(2006). RN [2] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=18802111; RA Roca F.J., Mulero I., Lopez-Munoz A., Sepulcre M.P., Renshaw S.A., RA Meseguer J., Mulero V.; RT "Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a RT powerful activator of endothelial cells but hardly activates phagocytes."; RL J. Immunol. 181:5071-5081(2008). RN [3] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=19201835; RA Sepulcre M.P., Alcaraz-Perez F., Lopez-Munoz A., Roca F.J., Meseguer J., RA Cayuela M.L., Mulero V.; RT "Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 RT does not recognize LPS and negatively regulates NF-kappaB activation."; RL J. Immunol. 182:1836-1845(2009). RN [4] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=19265122; RA Lopez-Munoz A., Roca F.J., Meseguer J., Mulero V.; RT "New insights into the evolution of IFNs: zebrafish group II IFNs induce a RT rapid and transient expression of IFN-dependent genes and display powerful RT antiviral activities."; RL J. Immunol. 182:3440-3449(2009). RN [5] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=19494299; RA Gong Y.F., Xiang L.X., Shao J.Z.; RT "CD154-CD40 interactions are essential for thymus-dependent antibody RT production in zebrafish: insights into the origin of costimulatory pathway RT in helper T cell-regulated adaptive immunity in early vertebrates."; RL J. Immunol. 182:7749-7762(2009). RN [6] {ECO:0000313|Ensembl:ENSDARP00000129202, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129202}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [7] {ECO:0000313|Ensembl:ENSDARP00000129202} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129202}; RG Ensembl; RL Submitted (MAR-2014) to UniProtKB. RN [8] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=29195089; RA Qiu W., Shao H., Lei P., Zheng C., Qiu C., Yang M., Zheng Y.; RT "Immunotoxicity of bisphenol S and F are similar to that of bisphenol A RT during zebrafish early development."; RL Chemosphere 194:1-8(2018). RN [9] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=30063756; RA Jensen H.M., Korbut R., Kania P.W., Buchmann K.; RT "Cannabidiol effects on behaviour and immune gene expression in zebrafish RT (Danio rerio)."; RL PLoS ONE 13:e0200016-e0200016(2018). RN [10] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=30204772; RA Jorgensen L.V.G., Korbut R., Jeberg S., Kania P.W., Buchmann K.; RT "Association between adaptive immunity and neutrophil dynamics in zebrafish RT (Danio rerio) infected by a parasitic ciliate."; RL PLoS ONE 13:e0203297-e0203297(2018). RN [11] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=29855567; RA Yang Q., Yan C., Gong Z.; RT "Interaction of hepatic stellate cells with neutrophils and macrophages in RT the liver following oncogenic kras activation in transgenic zebrafish."; RL Sci. Rep. 8:8495-8495(2018). RN [12] {ECO:0000313|RefSeq:NP_001007108.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RX PubMed=31057394; RA Kundap U.P., Paudel Y.N., Kumari Y., Othman I., Shaikh M.F.; RT "Embelin Prevents Seizure and Associated Cognitive Impairments in a RT Pentylenetetrazole-Induced Kindling Zebrafish Model."; RL Front. Pharmacol. 10:315-315(2019). RN [13] {ECO:0000313|RefSeq:NP_001007108.2} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001007108.2}; RG RefSeq; RL Submitted (SEP-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CT027672; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001007108.2; NM_001007107.2. DR STRING; 7955.ENSDARP00000129202; -. DR PaxDb; 7955-ENSDARP00000056760; -. DR Ensembl; ENSDART00000153685; ENSDARP00000129202; ENSDARG00000038878. DR Ensembl; ENSDART00000153685.3; ENSDARP00000129202.1; ENSDARG00000038878.7. DR GeneID; 445410; -. DR KEGG; dre:445410; -. DR CTD; 3592; -. DR ZFIN; ZDB-GENE-060724-1; il12a. DR HOGENOM; CLU_116337_0_0_1; -. DR OMA; KGFHLRV; -. DR OrthoDB; 4042115at2759; -. DR Proteomes; UP000000437; Chromosome 15. DR GO; GO:0043330; P:response to exogenous dsRNA; IDA:ZFIN. DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:ZFIN. DR GO; GO:0002237; P:response to molecule of bacterial origin; IDA:ZFIN. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR SUPFAM; SSF47266; 4-helical cytokines; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001007108.2}. FT SIGNAL 1..16 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 17..196 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001007108.2" FT /id="PRO_5035034113" SQ SEQUENCE 196 AA; 21586 MW; 423B570085CB8820 CRC64; MKICIVISMA LALALCSPVP PPDSQECVCS PAARSLLSAL THIMEKEGKM KEQDLFAGFN CTDLEAQMTP HTHTSSVCQP SVSANSSCSA HRSSNFSAVE CVKNIRGDLR YYDLLLNSYK PSTQELSPVI TANTQLINCL NQRCESAEGV FPQWRVWKGS SFDDRVSLCK TLKGFHIRSI TVNRALAYIA SGEHRK //