ID W8JCU2_PAPDA Unreviewed; 310 AA. AC W8JCU2; DT 14-MAY-2014, integrated into UniProtKB/TrEMBL. DT 14-MAY-2014, sequence version 1. DT 29-MAY-2024, entry version 22. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU000473}; GN Name=ND1 {ECO:0000313|EMBL:AHK61036.1}; OS Papilio dardanus (African swallowtail butterfly). OG Mitochondrion {ECO:0000313|EMBL:AHK61036.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea; OC Papilionidae; Papilioninae; Papilio. OX NCBI_TaxID=77259 {ECO:0000313|EMBL:AHK61036.1}; RN [1] {ECO:0000313|EMBL:AHK61036.1} RP NUCLEOTIDE SEQUENCE. RA Timmermans M.J.T.N., Lim J., Dodsworth S., Haran J., Ahrens D., Bocak L., RA London A., Culverwell L., Vogler A.P.; RT "Mitogenomics of the Coleoptera under dense taxon sampling."; RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00003257}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX313686; AHK61036.1; -; Genomic_DNA. DR AlphaFoldDB; W8JCU2; -. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0009060; P:aerobic respiration; IEA:TreeGrafter. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:AHK61036.1}; KW NAD {ECO:0000256|RuleBase:RU000471}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 6..25 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 74..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 105..125 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 145..165 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 177..196 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 225..248 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 255..271 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 291..309 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 310 AA; 35982 MW; 483C837AA9B186E4 CRC64; MYDIYMFFIG VLIMIIGVMV GVAFLTLLER QALGYIQIRK GPNKVGYMGI LQPFADVVKL FTKEQTFPNY SNYMAYYFSP ITSFIVILMS WILIPYYFNL ISFNLGILFF LCCTSVGVYT VMIAGWSSNS NYALLGGLRA VAQTISYEVS LALIMLSSII MIMSFNMINF FFYQEIIWFF FLMMPLSLCW LSSSLAETNR TPFDFAEGES ELVSGFNVEY SSGGFTLIFL SEYASILFMS MLFILLYLGG YSLSLIFYLK LSFISFMFIW VRGTLPRYRY DKLMYLSWKS YLPISLNFLL FFLGIKFFFY //