ID   W8GRJ8_9RHAB            Unreviewed;      2109 AA.
AC   W8GRJ8;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   20-DEC-2017, entry version 22.
DE   RecName: Full=Large structural protein {ECO:0000256|SAAS:SAAS00361167};
OS   Vesicular stomatitis Indiana virus.
OC   Viruses; ssRNA viruses; ssRNA negative-strand viruses;
OC   Mononegavirales; Rhabdoviridae; Vesiculovirus.
OX   NCBI_TaxID=11277 {ECO:0000313|EMBL:AHK23724.1, ECO:0000313|Proteomes:UP000181017};
RN   [1] {ECO:0000313|EMBL:AHK23724.1, ECO:0000313|Proteomes:UP000181017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mudd-Summers {ECO:0000313|EMBL:AHK23724.1};
RA   Wasik B.R., Bhushan A., Ogbunugafor C.B., Turner P.E.;
RT   "Delayed transmission selects for increased survival of vesicular
RT   stomatitis virus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000256|SAAS:SAAS00361115}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-
CC       adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
CC       {ECO:0000256|SAAS:SAAS00847042}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm
CC       {ECO:0000256|SAAS:SAAS00847043}. Virion
CC       {ECO:0000256|SAAS:SAAS00847032}.
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DR   EMBL; KF880914; AHK23724.1; -; Viral_cRNA.
DR   Proteomes; UP000181017; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026890; Mononeg_mRNAcap.
DR   InterPro; IPR014023; Mononeg_RNA_pol_cat.
DR   InterPro; IPR025786; Mononega_L_MeTrfase.
DR   InterPro; IPR017234; RNA-dir_pol_rhabdovirus.
DR   Pfam; PF14318; Mononeg_mRNAcap; 1.
DR   Pfam; PF00946; Mononeg_RNA_pol; 1.
DR   PIRSF; PIRSF037546; RNA_pol_RhabdoV_sub; 1.
DR   TIGRFAMs; TIGR04198; paramyx_RNAcap; 1.
DR   PROSITE; PS50526; RDRP_SSRNA_NEG_NONSEG; 1.
DR   PROSITE; PS51590; SAM_MT_MNV_L; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00503432};
KW   Complete proteome {ECO:0000313|Proteomes:UP000181017};
KW   Host cytoplasm {ECO:0000256|SAAS:SAAS00847045};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00847038};
KW   mRNA capping {ECO:0000256|SAAS:SAAS00503423};
KW   mRNA processing {ECO:0000256|SAAS:SAAS00503435};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00503427};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00503450};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00503444};
KW   RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00503441};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00503438};
KW   Transferase {ECO:0000256|SAAS:SAAS00503460};
KW   Viral RNA replication {ECO:0000256|SAAS:SAAS00503417};
KW   Virion {ECO:0000256|SAAS:SAAS00847034}.
FT   DOMAIN      598    784       RdRp catalytic. {ECO:0000259|PROSITE:
FT                                PS50526}.
FT   DOMAIN     1640   1837       Mononegavirus-type SAM-dependent 2'-O-
FT                                MTase. {ECO:0000259|PROSITE:PS51590}.
SQ   SEQUENCE   2109 AA;  240956 MW;  E3E73B21B11C7BF6 CRC64;
     MEVHDFETDE FNDFNEDDYA TREFLNPDER MTYLNHADYN LNSPLISDDI DNLIRKFNSL
     PIPSMWDSKN WDGVLEMLTS CQANPISTSQ MHKWMGSWLM SDNHDASQGY SFLHEVDKEA
     EITFDVVETF IRGWGNKPIE YIKKERWTDS FKILTYLCQK FLDLHKLTLI LNAVSEVELL
     NLARTFKCKV RRSSHGTNIC RIRVPSLGPT FISEGWAYFK KLDILMDRNF LLMVKDVIIG
     RMQTVLSMVC RIDNLFSEQD IFSLLNIYRI GDKIVERQGN FSYDLIKMVE PICNLKLMKL
     ARESRPLVPQ FPHFENHIKT SVDEGAKIDR GIRFLHDQIM SVKTVDLTLV IYGSFRHWGH
     PFIDYYTGLE KLHSQVTMKK DIDVSYAKAL ASDLARIVLF QQFNDHKKWF VNGDLLPHDH
     PFKSHVKENT WPTAAQVQDF GDKWHELPLI KCFEIPDLLD PSIIYSDKSH SMNRSEVLKH
     VRMNPNTPIP SKKVLQTMLD TKATNWKEFL KEIDEKGLDD DDLIIGLKGK ERELKLAGRF
     FSLMSWKLRE YFVITEYLIK THFVPMFKGL TMADDLTAVI KKMLDSSSGQ GLKSYEAICI
     ANHIDYEKWN NHQRKLSNGP VFRVMGQFLG YPSLIERTHE FFEKSLIYYN GRPDLMRVHN
     NTLINSTSQR VCWQGQEGGL EGLRQKGWSI LNLLVIQREA KIRNTAVKVL AQGDNQVICT
     QYKTKKSRNV VELQGALNQM VSNNEKIMTA IKIGTGKLGL LINDDETMQS ADYLNYGKIP
     IFRGVIRGLE TKRWSRVTCV TNDQIPTCAN IMSSVSTNAL TVAHFAENPI NAMIQYNYFG
     TFARLLLMMH DPALRQSLYE VQDKIPGLHS STFKYAMLYL DPSIGGVSGM SLSRFLIRAF
     PDPVTESLSF WRFIHVHAQS EHLKEMSAVF GNPEIAKFRI THIDKLVEDP TSLNIAMGMS
     PANLLKTEVK KCLIESRQTI RNQVIKDATI YLYHEEDRLR SFLWSINPLF PRFLSEFKSG
     TFLGVADGLI SLFQNSRTIR NSFKKKYHRE LDDLIVRSEV SSLTHLGKLH LRRGSCKMWT
     CSATHADTLR YKSWGRTVIG TTVPHPLEML GPQHRKETPC APCNTSGFNY VSVHCPDGIH
     DVFSSRGPLP AYLGSKTSES TSILQPWERE SKVPLIKRAT RLRDAISWFV EPDSKLAMTI
     LSNIHSLTGE EWTKRQHGFK RTGSALHRFS TSRMSHGGFA SQSTAALTRL MATTDTMRDL
     GDQNFDFLFQ ATLLYAQITT TVARDGWITS CTDHYHIACK SCLRPIEEIT LDSSMDYTPP
     DVSHVLKTWR NGEGSWGQEI KQIYPLEGNW KNLAPAEQSY QVGRCIGFLY GDLAYRKSTH
     AEDSSLFPLS IQGRIRGRGF LKGLLDGLMR ASCCQVIHRR SLAHLKRPAN AVYGGLIYLI
     DKLSVSPPFL SLTRSGPIRD ELETIPHKIP TSYPTSNRDM GVIVRNYFKY QCRLIEKGKY
     RSHYSQLWLF SDVLSIDFIG PFSISTTLLQ ILYKPFLSGK DKNELRELAN LSSLLRSGEG
     WEDIHVKFFT KDILLCPEEI RHACKFGIAK DNNKDMSYPP WGRESRGTIT TIPVYYTTTP
     SPKMLEMPPR IQNPLLSGIR LGQLPTGAHY KIRSILHGMG IHYRDFLSCG DGSGGMTAAL
     LRENVHSRGI FNSLLELSGS VMRGASPEPP SALETLGGDK SRCVNGETCW EYPSDLCDPR
     TWDYFLRLKA GLGLQIDLIV MDMEVRDSST SLKIETNVRN YVHRILDEQG VLIYKTYGTY
     ICESEKNAVT ILGPMFKTVD LVQTEFSSSQ TSEVYMVCKG LKKLIDEPNP DWSSINESWK
     NLYAFQSSEQ EFARAKKVST YFTLTGIPSQ FIPDPFVNIE TMLQIFGVPT GVSHAAALKS
     SDRPADLLTI SLFYMAIISY YNINHIRVGP IPPNPPSDGI AQNVGIAITG ISFWLSLMEK
     DIPLYQQCLA VIQQSFPIRW EAVSVKGGYK QKWSTRGDGL PKDTRISDSL APIGNWIRSL
     ELVRNQVRLN PFNEILFNQL CRTVDNHLKW SNLRRNTGMI EWINRRISKE DRSILMLKSD
     LHEENSWRD
//