ID W8FK29_9EUPU Unreviewed; 204 AA. AC W8FK29; DT 14-MAY-2014, integrated into UniProtKB/TrEMBL. DT 14-MAY-2014, sequence version 1. DT 18-JAN-2017, entry version 14. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:AHK05620.1}; OS Limax cinereoniger. OG Mitochondrion {ECO:0000313|EMBL:AHK05620.1}. OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; OC Stylommatophora; Sigmurethra; Limacoidea; Limacidae; Limax. OX NCBI_TaxID=665645 {ECO:0000313|EMBL:AHK05620.1}; RN [1] {ECO:0000313|EMBL:AHK05620.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Y31 {ECO:0000313|EMBL:AHK05620.1}; RX PubMed=24740519; RA Rowson B., Anderson R., Turner J.A., Symondson W.O.; RT "The slugs of britain and ireland: undetected and undescribed species RT increase a well-studied, economically important fauna by more than RT 20%."; RL PLoS ONE 9:E91907-E91907(2014). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU000369}. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF894380; AHK05620.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; KW Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, KW ECO:0000313|EMBL:AHK05620.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Transmembrane {ECO:0000256|RuleBase:RU000369, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 24 52 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 73 97 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 117 142 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 154 181 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 204 COX1. {ECO:0000259|PROSITE:PS50855}. FT NON_TER 1 1 {ECO:0000313|EMBL:AHK05620.1}. FT NON_TER 204 204 {ECO:0000313|EMBL:AHK05620.1}. SQ SEQUENCE 204 AA; 21980 MW; 0947CD62D22618F1 CRC64; VGTGLSLLIR LELGTAGVLM DDHFFNVIVT AHAFVMIFFM VMPIMIGGFG NWMVPLLIGA PDMSFPRMNN MSFWLLPPSF ILLICSSMVE GGAGTGWTVY PPLSGPLGHG GASVDLAIFS LHLAGMSSIL GAINFITTIF NMRTSGMTME RVSLFVWSIL VTVFLLLLSL PVLAGAITML LTDRNFNTSF FDPAGGGDPI LYQH //