ID W6S4Q7_9CYAN Unreviewed; 274 AA. AC W6S4Q7; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 14-MAY-2014, entry version 2. DE RecName: Full=Ribosomal RNA small subunit methyltransferase A; DE EC=2.1.1.182; DE AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; DE AltName: Full=16S rRNA dimethyladenosine transferase; DE AltName: Full=16S rRNA dimethylase; DE AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase; GN Name=ksgA; Synonyms=rsmA; ORFNames=ARTHRO_11116; OS Arthrospira sp. OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales; OC Arthrospira. OX NCBI_TaxID=35824; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=PCC 8005; RA Genoscope - CEA; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Specifically dimethylates two adjacent adenosines (A1518 CC and A1519) in the loop of a conserved hairpin near the 3'-end of CC 16S rRNA in the 30S particle. May play a critical role in CC biogenesis of 30S subunits (By similarity). CC -!- CATALYTIC ACTIVITY: 4 S-adenosyl-L-methionine + CC adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L- CC homocysteine + N(6)-dimethyladenine(1518)/N(6)- CC dimethyladenine(1519) in 16S rRNA. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the class I-like SAM-binding CC methyltransferase superfamily. rRNA adenine N(6)-methyltransferase CC family. RsmA subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO818640; CDM93443.1; -; Genomic_DNA. DR Gene3D; 1.10.8.100; -; 1. DR HAMAP; MF_00607; 16SrRNA_methyltr_A; 1. DR InterPro; IPR023165; rRNA_Ade_diMease-like. DR InterPro; IPR020596; rRNA_Ade_Mease_Trfase_CS. DR InterPro; IPR001737; rRNA_Ade_methylase_transferase. DR InterPro; IPR020598; rRNA_Ade_methylase_Trfase_N. DR InterPro; IPR011530; rRNA_adenine_dimethylase. DR PANTHER; PTHR11727; PTHR11727; 1. DR Pfam; PF00398; RrnaAD; 1. DR SMART; SM00650; rADc; 1. DR TIGRFAMs; TIGR00755; ksgA; 1. DR PROSITE; PS01131; RRNA_A_DIMETH; 1. PE 3: Inferred from homology; KW Cytoplasm; Methyltransferase; RNA-binding; rRNA processing; KW S-adenosyl-L-methionine; Transferase. FT BINDING 13 13 S-adenosyl-L-methionine; via carbonyl FT oxygen (By similarity). FT BINDING 15 15 S-adenosyl-L-methionine; via amide FT nitrogen (By similarity). FT BINDING 40 40 S-adenosyl-L-methionine; via carbonyl FT oxygen (By similarity). FT BINDING 61 61 S-adenosyl-L-methionine (By similarity). FT BINDING 86 86 S-adenosyl-L-methionine (By similarity). FT BINDING 111 111 S-adenosyl-L-methionine (By similarity). SQ SEQUENCE 274 AA; 30300 MW; 13B8E47D29FEF267 CRC64; MPSPQPRKRF AQHWLRSPAT LNHILEAADL SLGDRILEIG PGTGILTERL LPKVSSVVAV EIDRDLCVQL AKKFGKIDNF LLLQGDILNF DLNGYLSGFP KFQNPNKVVA NIPYNITGPI IEGLLGTIAK PAVKPFDAIV LLVQKEVGAR LCAKPSSKAF GALSVRVQYL AECDWICHVP ATAFYPPPKV DSAVVRLRPR PIASPAQNPQ LLETLVKLGF STRRKMLRNN LKSQVEPQTL NQLLETLDIN PQVRAEDLSL QQWVQLSNLL LAPQ //