ID W6PPA1_MOUSE Unreviewed; 2622 AA. AC W6PPA1; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 02-JUN-2021, entry version 34. DE SubName: Full=270-kDa ankyrinG {ECO:0000313|EMBL:CDM21876.1}; GN Name=Ank3 {ECO:0000313|EMBL:CDM21876.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CDM21876.1}; RN [1] {ECO:0000313|EMBL:CDM21876.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57Bl6 {ECO:0000313|EMBL:CDM21876.1}; RA Barbara L.; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CDM21876.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57Bl6 {ECO:0000313|EMBL:CDM21876.1}; RA Freal A., Le Bras B., Fassier C., Bullier E., De Gois S., Hazan J., RA Couraud F.; RT "480-kDa Ankyrin G and not its 270-kDa isoform assembles the axon initial RT segment."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton CC {ECO:0000256|ARBA:ARBA00004245}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HG915715; CDM21876.1; -; Genomic_DNA. DR ChiTaRS; Ank3; mouse. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd08803; Death_ank3; 1. DR Gene3D; 1.25.40.20; -; 3. DR InterPro; IPR037971; Ank3_Death. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR040745; Ankyrin_UPA. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR000906; ZU5_dom. DR Pfam; PF00023; Ank; 2. DR Pfam; PF12796; Ank_2; 8. DR Pfam; PF13606; Ank_3; 1. DR Pfam; PF00531; Death; 1. DR Pfam; PF17809; UPA_2; 1. DR Pfam; PF00791; ZU5; 1. DR PRINTS; PR01415; ANKYRIN. DR SMART; SM00248; ANK; 22. DR SMART; SM00005; DEATH; 1. DR SMART; SM00218; ZU5; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR SUPFAM; SSF48403; SSF48403; 3. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 21. DR PROSITE; PS50017; DEATH_DOMAIN; 1. DR PROSITE; PS51145; ZU5; 2. PE 4: Predicted; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 40..815 FT /note="ANK_REP_REGION" FT /evidence="ECO:0000259|PROSITE:PS50297" FT REPEAT 73..105 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 106..138 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 139..171 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 172..195 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 234..266 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 267..299 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 300..332 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 333..365 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 366..398 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 399..431 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 432..464 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 465..497 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 498..530 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 531..563 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 564..596 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 597..629 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 630..662 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 663..695 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 696..728 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 729..761 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 762..794 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT DOMAIN 984..1139 FT /note="ZU5" FT /evidence="ECO:0000259|PROSITE:PS51145" FT DOMAIN 1141..1288 FT /note="ZU5" FT /evidence="ECO:0000259|PROSITE:PS51145" FT DOMAIN 2335..2419 FT /note="Death" FT /evidence="ECO:0000259|PROSITE:PS50017" FT REGION 1..44 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 862..881 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1510..1537 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1967..1991 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2098..2146 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2168..2200 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2291..2312 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2571..2622 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..27 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2102..2119 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2120..2136 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2579..2622 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2622 AA; 284662 MW; AC6A1AD505BC0338 CRC64; MAHAASQLKK NRDLEINAEE ETEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVRFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDTNADV ESKSGFTPLH IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD GLTPLHCGAR SGHEQVVEML LDRSAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ASPNAKALNG FTPLHIACKK NRIRVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLAA REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ASLLLQKSAS PDAAGKSGLT PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATSL LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLSRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNAKT KNGYTALHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL AIARRLGYIS VVDTLKVVTE EIMTTTTITE KHKMNVPETM NEVLDMSDDE VRKASAPEKL SDGEYISDGE EGEDAITGDT DKYLGPQDLK ELGDDSLPAE GYVGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT FTREFDSDSL RHYSWAADTL DNVNLVSSPV HSGFLVSFMV DARGGSMRGS RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL AELLNGMDEE LDSPEELGTK RICRIITKDF PQYFAVVSRI KQESNQIGPE GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPEETVK KILGNKATFS PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDATP NLRLLCSITG GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLASQ LYRELICVPY MAKFVVFAKT NDPVESSLRC FCMTDDRVDK TLEQQENFEE VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYSF KENRLPFSIK IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDA EKADRRQSFA SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS TRPYQSWTTA PITVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS TLGASTTSSV KSISDVASPI RSFRTVSSPI KTVVSPSPYN PQVASGTLGR VPTITEATPI KGLAPNSTFS SRTSPVTTAG SLLERSSITM TPPASPKSNI TMYSSSLPFK SIITSATPLI SSPLKSVVSP TKSAADVIST AKATMASSLS SPLKQMSGHA EVALVNGSVS PLKYPSSSAL INGCKATATL QDKISTATNA VSSVVSAASD TVEKALSTTT AMPFSPLRSY VSAAPSAFQS LRTPSASALY TSLGSSIAAT TSSVTSSIIT VPVYSVVNVL PEPALKKLPD SNSFTKSAAA LLSPIKTLTT ETRPQPHFNR TSSPVKSSLF LASSALKPSV PSSLSSSQEI LKDVAEMKED LMRMTAILQT DVPEEKPFQT DLPREGRIDD EEPFKIVEKV KEDLVKVSEI LKKDVCVESK GPPKSPKSDK GHSPEDDWTE FSSEEIREAR QAAASHAPSL PERVHGKANL TRVIDYLTND IGSSSLTNLK YKFEEAKKDG EERQKRILKP AMALQEHKLK MPPASMRPST SEKELCKMAD SFFGADAILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK PLFHEVPIPP VITETRTEVV HVIRSYEPSS GEIPQSQPED PVSPKPSPTF MELEPKPTTS SIKEKVKAFQ MKASSEEEDH SRVLSKGMRV KEETHITTTT RMVYHSPPGG ECASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAM SPDVAKSAAE TSAQHAEKDS QMKPKLERII EVHIEKGPQS PCERTDIRMA IVADHLGLSW TELARELNFS VDEINQIRVE NPNSLISQSF MLLKKWVTRD GKNATTDALT SVLTKINRID IVTLLEGPIF DYGNISGTRS FADENNVFHD PVDGWQNETP SGSLESPAQA RRLTGGLLDR LDDSSDQARD SITSYLTGEP GKIEANGNHT AEVIPEAKAK PYFPESQNDI GKQSIKENLK PKTHGCGRTE EPVSPLTAYQ KSLEETSKLV IEDAPKPCVP VGMKKMTRTT ADGKARLNLQ EEEGSTRSEP KQGEGYKVKT KKEIRNVEKK TH //