ID W6AAJ2_9PLVG Unreviewed; 854 AA. AC W6AAJ2; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 27-SEP-2017, entry version 28. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095}; DE Short=SU {ECO:0000256|RuleBase:RU363095}; DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095}; DE Short=gp120 {ECO:0000256|RuleBase:RU363095}; DE Contains: DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095}; DE Short=TM {ECO:0000256|RuleBase:RU363095}; GN Name=env {ECO:0000313|EMBL:AHI49258.1}; OS Simian-Human immunodeficiency virus. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group; OC unclassified Primate lentivirus group. OX NCBI_TaxID=57667 {ECO:0000313|EMBL:AHI49258.1}; RN [1] {ECO:0000313|EMBL:AHI49258.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Ba-L {ECO:0000313|EMBL:AHI49258.1}; RX PubMed=23966410; DOI=10.1128/JVI.01361-13; RA Klein K., Veazey R.S., Warrier R., Hraber P., Doyle-Meyers L.A., RA Buffa V., Liao H.X., Haynes B.F., Shaw G.M., Shattock R.J.; RT "Neutralizing IgG at the portal of infection mediates protection RT against vaginal simian/human immunodeficiency virus challenge."; RL J. Virol. 87:11604-11616(2013). CC -!- SUBUNIT: The mature envelope protein (Env) consists of a CC homotrimer of non-covalently associated gp120-gp41 heterodimers. CC The resulting complex protrudes from the virus surface as a spike. CC {ECO:0000256|RuleBase:RU363095}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00797336}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00797336}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00797479}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00797479}. CC -!- SUBCELLULAR LOCATION: Host endosome membrane CC {ECO:0000256|SAAS:SAAS00797669}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00797669}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00796993}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00796993}. CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is CC present in many retroviral envelope proteins. Synthetic peptides CC derived from this relatively conserved sequence inhibit immune CC function in vitro and in vivo. {ECO:0000256|RuleBase:RU363095}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU363095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF734264; AHI49258.1; -; Other_DNA. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR CDD; cd09909; HIV-1-like_HR1-HR2; 1. DR InterPro; IPR000328; GP41-like. DR InterPro; IPR000777; HIV1_GP160. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 4: Predicted; KW Apoptosis {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797441}; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU363095}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00487956}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00487637}; KW Host cell membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797298}; KW Host endosome {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797530}; KW Host membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797793}; KW Host-virus interaction {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797036}; KW Membrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797370}; KW Transmembrane {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797262}; KW Transmembrane helix {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797734}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797747}; KW Viral envelope protein {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797156, ECO:0000313|EMBL:AHI49258.1}; KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00132213}; KW Virion {ECO:0000256|RuleBase:RU363095, ECO:0000256|SAAS:SAAS00796948}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095, KW ECO:0000256|SAAS:SAAS00797206}. FT TRANSMEM 510 533 Helical. {ECO:0000256|RuleBase:RU363095}. FT TRANSMEM 676 697 Helical. {ECO:0000256|RuleBase:RU363095}. FT DOMAIN 33 509 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 528 717 GP41. {ECO:0000259|Pfam:PF00517}. SQ SEQUENCE 854 AA; 96901 MW; 73985989DE2602A3 CRC64; MRVTEIRKSY QHWWRWGIML LGILMICNAE EKLWVTVYYG VPVWKEATTT LFCASDAKAY DTEVHNVWAT HACVPTDPNP QEVELKNVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK LTPLCVTLNC TDLGNATNGN DTNTTSSSRG MVGGGEMKNC SFNITTNIRS KVQKEYALFY KLDIAPIDNN SNNRYRLISC NTSVITQACP KVSFEPIPIH YCAPAGFAIL KCKDKKFNGK GPCTNVSTVQ CTHGIRPLVS TQLLLNGSLA EEEVVIRSAN FADNAKIIIV QLNESVEINC TRPNNNTRKS IHIGPGRAFY TTGEIIGDIR QAHCNLSRAK WNDTLNKIVI KLREQFGNKT IVFKHSSGGD PEIVTHSFNC GGEFFYCDST QLFNSTWNVT EESNNTVENN TITLPCRIKQ IINMWQEVGR AMYAPPIRGQ IRCSSNITGL LLTRDGGPED NKTEVFRPGG GDMRDNWRSE LYKYKVVKIE PLGVAPTKAK RRVVQREKRA VGIGAVFLGF LGAAGSTMGA AAMTLTVQAR LLLSGIVQQQ NNLLRAIEAQ QHLLQLTVWG VKQLQARVLA VERYLRDQQL LGIWGCSGKL ICTTAVPWNA SWNNKSLNKI WDNMTWIEWD REINNYTSII YSLIEESQNQ QEKNEQELLE LDKWASLWNW FDITKWLWYI KIFIMIVGGL IGLRIVFSVL SIVNRVRQGY SPLSFQTHLP ASRGPDRPGG IEEEGGERDR DRSGPLVNGF LALIWVDLRS LFLFSYHRLR DLLLIVTRIV ELLGRRGWEV LKYWWNLLQY WSQELKNSAV SLLNATAVAV AEGTDRVIEV LQRAVRAILH IPRRIRQGLE RALL //