ID   W6A110_9PLVG            Unreviewed;       854 AA.
AC   W6A110;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   26-NOV-2014, entry version 7.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU004292};
GN   Name=env {ECO:0000313|EMBL:AHI49131.1};
OS   Simian-Human immunodeficiency virus.
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Lentivirus; Primate lentivirus group;
OC   unclassified Primate lentivirus group.
OX   NCBI_TaxID=57667 {ECO:0000313|EMBL:AHI49131.1};
RN   [1] {ECO:0000313|EMBL:AHI49131.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ba-L {ECO:0000313|EMBL:AHI49131.1};
RX   PubMed=23966410; DOI=10.1128/JVI.01361-13;
RA   Klein K., Veazey R.S., Warrier R., Hraber P., Doyle-Meyers L.A.,
RA   Buffa V., Liao H.X., Haynes B.F., Shaw G.M., Shattock R.J.;
RT   "Neutralizing IgG at the portal of infection mediates protection
RT   against vaginal simian/human immunodeficiency virus challenge.";
RL   J. Virol. 87:11604-11616(2013).
CC   -!- FUNCTION: The envelope glyprotein gp160 precursor down-modulates
CC       cell surface CD4 antigen by interacting with it in the endoplasmic
CC       reticulum and blocking its transport to the cell surface.
CC       {ECO:0000256|RuleBase:RU004292, ECO:0000256|SAAS:SAAS00139820}.
CC   -!- FUNCTION: The gp120-gp41 heterodimer allows rapid transcytosis of
CC       the virus through CD4 negative cells such as simple epithelial
CC       monolayers of the intestinal, rectal and endocervical epithelial
CC       barriers. Both gp120 and gp41 specifically recognize
CC       glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-
CC       galactosyl-ceramide (GalS) present in the lipid rafts structures
CC       of epithelial cells. Binding to these alternative receptors allows
CC       the rapid transcytosis of the virus through the epithelial cells.
CC       This transcytotic vesicle-mediated transport of virions from the
CC       apical side to the basolateral side of the epithelial cells does
CC       not involve infection of the cells themselves.
CC       {ECO:0000256|SAAS:SAAS00140087}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane
CC       {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00140070}. Host cell membrane
CC       {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00140070}. Host endosome membrane
CC       {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00140070}.
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DR   EMBL; KF734097; AHI49117.1; -; Other_DNA.
DR   EMBL; KF734099; AHI49118.1; -; Other_DNA.
DR   EMBL; KF734100; AHI49119.1; -; Other_DNA.
DR   EMBL; KF734103; AHI49120.1; -; Other_DNA.
DR   EMBL; KF734104; AHI49121.1; -; Other_DNA.
DR   EMBL; KF734106; AHI49123.1; -; Other_DNA.
DR   EMBL; KF734109; AHI49125.1; -; Other_DNA.
DR   EMBL; KF734110; AHI49126.1; -; Other_DNA.
DR   EMBL; KF734111; AHI49127.1; -; Other_DNA.
DR   EMBL; KF734116; AHI49130.1; -; Other_DNA.
DR   EMBL; KF734117; AHI49131.1; -; Other_DNA.
DR   EMBL; KF734118; AHI49132.1; -; Other_DNA.
DR   EMBL; KF734120; AHI49134.1; -; Other_DNA.
DR   EMBL; KF734150; AHI49160.1; -; Other_DNA.
DR   EMBL; KF734151; AHI49161.1; -; Other_DNA.
DR   EMBL; KF734152; AHI49162.1; -; Other_DNA.
DR   EMBL; KF734155; AHI49165.1; -; Other_DNA.
DR   EMBL; KF734156; AHI49166.1; -; Other_DNA.
DR   EMBL; KF734157; AHI49167.1; -; Other_DNA.
DR   EMBL; KF734158; AHI49168.1; -; Other_DNA.
DR   EMBL; KF734159; AHI49169.1; -; Other_DNA.
DR   EMBL; KF734163; AHI49172.1; -; Other_DNA.
DR   EMBL; KF734166; AHI49175.1; -; Other_DNA.
DR   EMBL; KF734167; AHI49176.1; -; Other_DNA.
DR   EMBL; KF734169; AHI49178.1; -; Other_DNA.
DR   EMBL; KF734174; AHI49182.1; -; Other_DNA.
DR   EMBL; KF734177; AHI49185.1; -; Other_DNA.
DR   EMBL; KF734178; AHI49186.1; -; Other_DNA.
DR   EMBL; KF734179; AHI49187.1; -; Other_DNA.
DR   EMBL; KF734181; AHI49188.1; -; Other_DNA.
DR   EMBL; KF734183; AHI49189.1; -; Other_DNA.
DR   EMBL; KF734184; AHI49190.1; -; Other_DNA.
DR   EMBL; KF734324; AHI49309.1; -; Other_DNA.
DR   EMBL; KF734325; AHI49310.1; -; Other_DNA.
DR   EMBL; KF734331; AHI49315.1; -; Other_DNA.
DR   EMBL; KF734335; AHI49317.1; -; Other_DNA.
DR   EMBL; KF734337; AHI49319.1; -; Other_DNA.
DR   EMBL; KF734344; AHI49326.1; -; Other_DNA.
DR   EMBL; KF734354; AHI49335.1; -; Other_DNA.
DR   EMBL; KF734356; AHI49337.1; -; Other_DNA.
DR   EMBL; KF734357; AHI49338.1; -; Other_DNA.
DR   EMBL; KF734358; AHI49339.1; -; Other_DNA.
DR   EMBL; KF734361; AHI49342.1; -; Other_DNA.
DR   EMBL; KF734366; AHI49347.1; -; Other_DNA.
DR   EMBL; KF734367; AHI49348.1; -; Other_DNA.
DR   EMBL; KF734368; AHI49349.1; -; Other_DNA.
DR   EMBL; KF734369; AHI49350.1; -; Other_DNA.
DR   EMBL; KF734372; AHI49352.1; -; Other_DNA.
DR   EMBL; KF734374; AHI49354.1; -; Other_DNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.40.20; -; 2.
DR   InterPro; IPR000777; HIV1_GP160.
DR   InterPro; IPR000328; Retroviral_envelope_protein.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; SSF56502; 2.
PE   4: Predicted;
KW   AIDS {ECO:0000256|RuleBase:RU003294};
KW   Apoptosis {ECO:0000256|SAAS:SAAS00140089};
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU004292};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00132312};
KW   Fusion of virus membrane with host membrane
KW   {ECO:0000256|SAAS:SAAS00132404};
KW   Host cell membrane {ECO:0000256|SAAS:SAAS00139780};
KW   Host endosome {ECO:0000256|SAAS:SAAS00139996};
KW   Host membrane {ECO:0000256|SAAS:SAAS00140080};
KW   Host-virus interaction {ECO:0000256|RuleBase:RU003294,
KW   ECO:0000256|SAAS:SAAS00132180};
KW   Membrane {ECO:0000256|RuleBase:RU004292,
KW   ECO:0000256|SAAS:SAAS00140028};
KW   Transmembrane {ECO:0000256|RuleBase:RU004292,
KW   ECO:0000256|SAAS:SAAS00140092};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00140305};
KW   Viral attachment to host cell {ECO:0000256|RuleBase:RU004292,
KW   ECO:0000256|SAAS:SAAS00131527};
KW   Viral envelope protein {ECO:0000256|RuleBase:RU003294,
KW   ECO:0000256|SAAS:SAAS00140357};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU004292};
KW   Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00132213};
KW   Virion {ECO:0000256|RuleBase:RU004292, ECO:0000256|SAAS:SAAS00139810};
KW   Virus entry into host cell {ECO:0000256|SAAS:SAAS00132354}.
SQ   SEQUENCE   854 AA;  96972 MW;  F4A7CB534239E931 CRC64;
     MRVTEIRKSY QHWWRWGIML LGILMICNAE EKLWVTVYYG VPVWKEATTT LFCASDAKAY
     DTEEHNVWAT HACVPTDPNP QEVELKNVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK
     LTPLCVTLNC TDLRNATNGN DTNTTSSSRG MVGGGEMKNC SFNITTNIRG KVQKEYALFY
     KLDIAPIDNN SNNRYRLISC NTSVITQACP KVSFEPIPIH YCAPAGFAIL KCKDKKFNGK
     GPCTNVSTVQ CTHGIRPVVS TQLLLNGSLA EEEVVIRSAN FADNAKIIIV QLNESVEINC
     TRPNNNTRKS IHIGPGRAFY TTGEIIGDIR QAHCNLSRAK WNDTLNKIVI KLREQFGNKT
     IVFKHSSGGD PEIVTHSFNC GGEFFYCDST QLFNSTWNVT EESNNTVENN TITLPCRIKQ
     IINMWQEVGR AMYAPPIRGQ IRCSSNITGL LLTRDGGPED NKTEVFRPGG GDMRDNWRSE
     LYKYKVVKIE PLGVAPTKAK RRVVQREKRA VGIGAVFLGF LGAAGSTMGA AAMTLTVQAR
     LLLSGIVQQQ NNLLRAIEAQ QHLLQLTVWG VKQLQARVLA VERYLRDQQL LGIWGCSGKL
     ICTTAVPWNA SWSNKSLNKI WDNMTWIEWD REINNYTSII YSLIEESQNQ QEKNEQELLE
     LDKWASLWNW FDITKWLWYI KIFIMIVGGL IGLRIVFSVL SIVNRVRQGY SPLSFQTHLP
     ASRGPDRPGG IEEEGGERDR DRSGPLVNGF LALIWVDLRS LFLFSYHRLR DLLLIVIRIV
     ELLGRRGWEV LKYWWNLLQY WSQELKNSAV SLLNATAVAV AEGTDRVIEV LQRAVRAILH
     IPRRIRQGLE RALL
//