ID   W6A110_9PLVG            Unreviewed;       854 AA.
AC   W6A110;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-SEP-2016, entry version 24.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|SAAS:SAAS00411610};
GN   Name=env {ECO:0000313|EMBL:AHI49131.1};
OS   Simian-Human immunodeficiency virus.
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Lentivirus; Primate lentivirus group;
OC   unclassified Primate lentivirus group.
OX   NCBI_TaxID=57667 {ECO:0000313|EMBL:AHI49131.1};
RN   [1] {ECO:0000313|EMBL:AHI49131.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ba-L {ECO:0000313|EMBL:AHI49131.1};
RX   PubMed=23966410; DOI=10.1128/JVI.01361-13;
RA   Klein K., Veazey R.S., Warrier R., Hraber P., Doyle-Meyers L.A.,
RA   Buffa V., Liao H.X., Haynes B.F., Shaw G.M., Shattock R.J.;
RT   "Neutralizing IgG at the portal of infection mediates protection
RT   against vaginal simian/human immunodeficiency virus challenge.";
RL   J. Virol. 87:11604-11616(2013).
CC   -!- SUBCELLULAR LOCATION: Host cell membrane
CC       {ECO:0000256|SAAS:SAAS00595805}; Peripheral membrane protein
CC       {ECO:0000256|SAAS:SAAS00595805}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane
CC       {ECO:0000256|SAAS:SAAS00595638}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00595638}.
CC   -!- SUBCELLULAR LOCATION: Host endosome membrane
CC       {ECO:0000256|SAAS:SAAS00595816}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00595816}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane
CC       {ECO:0000256|SAAS:SAAS00595588}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS00595588}.
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DR   EMBL; KF734097; AHI49117.1; -; Other_DNA.
DR   EMBL; KF734099; AHI49118.1; -; Other_DNA.
DR   EMBL; KF734100; AHI49119.1; -; Other_DNA.
DR   EMBL; KF734103; AHI49120.1; -; Other_DNA.
DR   EMBL; KF734104; AHI49121.1; -; Other_DNA.
DR   EMBL; KF734106; AHI49123.1; -; Other_DNA.
DR   EMBL; KF734109; AHI49125.1; -; Other_DNA.
DR   EMBL; KF734110; AHI49126.1; -; Other_DNA.
DR   EMBL; KF734111; AHI49127.1; -; Other_DNA.
DR   EMBL; KF734116; AHI49130.1; -; Other_DNA.
DR   EMBL; KF734117; AHI49131.1; -; Other_DNA.
DR   EMBL; KF734118; AHI49132.1; -; Other_DNA.
DR   EMBL; KF734120; AHI49134.1; -; Other_DNA.
DR   EMBL; KF734150; AHI49160.1; -; Other_DNA.
DR   EMBL; KF734151; AHI49161.1; -; Other_DNA.
DR   EMBL; KF734152; AHI49162.1; -; Other_DNA.
DR   EMBL; KF734155; AHI49165.1; -; Other_DNA.
DR   EMBL; KF734156; AHI49166.1; -; Other_DNA.
DR   EMBL; KF734157; AHI49167.1; -; Other_DNA.
DR   EMBL; KF734158; AHI49168.1; -; Other_DNA.
DR   EMBL; KF734159; AHI49169.1; -; Other_DNA.
DR   EMBL; KF734163; AHI49172.1; -; Other_DNA.
DR   EMBL; KF734166; AHI49175.1; -; Other_DNA.
DR   EMBL; KF734167; AHI49176.1; -; Other_DNA.
DR   EMBL; KF734169; AHI49178.1; -; Other_DNA.
DR   EMBL; KF734174; AHI49182.1; -; Other_DNA.
DR   EMBL; KF734177; AHI49185.1; -; Other_DNA.
DR   EMBL; KF734178; AHI49186.1; -; Other_DNA.
DR   EMBL; KF734179; AHI49187.1; -; Other_DNA.
DR   EMBL; KF734181; AHI49188.1; -; Other_DNA.
DR   EMBL; KF734183; AHI49189.1; -; Other_DNA.
DR   EMBL; KF734184; AHI49190.1; -; Other_DNA.
DR   EMBL; KF734324; AHI49309.1; -; Other_DNA.
DR   EMBL; KF734325; AHI49310.1; -; Other_DNA.
DR   EMBL; KF734331; AHI49315.1; -; Other_DNA.
DR   EMBL; KF734335; AHI49317.1; -; Other_DNA.
DR   EMBL; KF734337; AHI49319.1; -; Other_DNA.
DR   EMBL; KF734344; AHI49326.1; -; Other_DNA.
DR   EMBL; KF734354; AHI49335.1; -; Other_DNA.
DR   EMBL; KF734356; AHI49337.1; -; Other_DNA.
DR   EMBL; KF734357; AHI49338.1; -; Other_DNA.
DR   EMBL; KF734358; AHI49339.1; -; Other_DNA.
DR   EMBL; KF734361; AHI49342.1; -; Other_DNA.
DR   EMBL; KF734366; AHI49347.1; -; Other_DNA.
DR   EMBL; KF734367; AHI49348.1; -; Other_DNA.
DR   EMBL; KF734368; AHI49349.1; -; Other_DNA.
DR   EMBL; KF734369; AHI49350.1; -; Other_DNA.
DR   EMBL; KF734372; AHI49352.1; -; Other_DNA.
DR   EMBL; KF734374; AHI49354.1; -; Other_DNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 2.170.40.20; -; 2.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_GP160.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; SSF56502; 2.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|SAAS:SAAS00491382};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00487956};
KW   Fusion of virus membrane with host membrane
KW   {ECO:0000256|SAAS:SAAS00487637};
KW   Host cell membrane {ECO:0000256|SAAS:SAAS00491210};
KW   Host endosome {ECO:0000256|SAAS:SAAS00491443};
KW   Host membrane {ECO:0000256|SAAS:SAAS00493156};
KW   Host-virus interaction {ECO:0000256|SAAS:SAAS00490508};
KW   Membrane {ECO:0000256|SAAS:SAAS00491184, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00491847,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00490549,
KW   ECO:0000256|SAM:Phobius};
KW   Viral attachment to host cell {ECO:0000256|SAAS:SAAS00490424};
KW   Viral envelope protein {ECO:0000256|SAAS:SAAS00490691,
KW   ECO:0000313|EMBL:AHI49131.1};
KW   Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00486890};
KW   Virion {ECO:0000256|SAAS:SAAS00491099};
KW   Virus entry into host cell {ECO:0000256|SAAS:SAAS00490724}.
FT   TRANSMEM    510    533       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    676    697       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    509       GP120. {ECO:0000259|Pfam:PF00516}.
FT   DOMAIN      528    717       GP41. {ECO:0000259|Pfam:PF00517}.
SQ   SEQUENCE   854 AA;  96972 MW;  F4A7CB534239E931 CRC64;
     MRVTEIRKSY QHWWRWGIML LGILMICNAE EKLWVTVYYG VPVWKEATTT LFCASDAKAY
     DTEEHNVWAT HACVPTDPNP QEVELKNVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK
     LTPLCVTLNC TDLRNATNGN DTNTTSSSRG MVGGGEMKNC SFNITTNIRG KVQKEYALFY
     KLDIAPIDNN SNNRYRLISC NTSVITQACP KVSFEPIPIH YCAPAGFAIL KCKDKKFNGK
     GPCTNVSTVQ CTHGIRPVVS TQLLLNGSLA EEEVVIRSAN FADNAKIIIV QLNESVEINC
     TRPNNNTRKS IHIGPGRAFY TTGEIIGDIR QAHCNLSRAK WNDTLNKIVI KLREQFGNKT
     IVFKHSSGGD PEIVTHSFNC GGEFFYCDST QLFNSTWNVT EESNNTVENN TITLPCRIKQ
     IINMWQEVGR AMYAPPIRGQ IRCSSNITGL LLTRDGGPED NKTEVFRPGG GDMRDNWRSE
     LYKYKVVKIE PLGVAPTKAK RRVVQREKRA VGIGAVFLGF LGAAGSTMGA AAMTLTVQAR
     LLLSGIVQQQ NNLLRAIEAQ QHLLQLTVWG VKQLQARVLA VERYLRDQQL LGIWGCSGKL
     ICTTAVPWNA SWSNKSLNKI WDNMTWIEWD REINNYTSII YSLIEESQNQ QEKNEQELLE
     LDKWASLWNW FDITKWLWYI KIFIMIVGGL IGLRIVFSVL SIVNRVRQGY SPLSFQTHLP
     ASRGPDRPGG IEEEGGERDR DRSGPLVNGF LALIWVDLRS LFLFSYHRLR DLLLIVIRIV
     ELLGRRGWEV LKYWWNLLQY WSQELKNSAV SLLNATAVAV AEGTDRVIEV LQRAVRAILH
     IPRRIRQGLE RALL
//