ID   W5ZYM9_9SALA            Unreviewed;        82 AA.
AC   W5ZYM9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   02-OCT-2024, entry version 24.
DE   SubName: Full=Proopiomelanocortin {ECO:0000313|EMBL:AHI47313.1};
DE   Flags: Fragment;
GN   Name=POMC {ECO:0000313|EMBL:AHI47313.1};
OS   Salamandra infraimmaculata infraimmaculata.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Salamandrinae;
OC   Salamandra.
OX   NCBI_TaxID=353261 {ECO:0000313|EMBL:AHI47313.1};
RN   [1] {ECO:0000313|EMBL:AHI47313.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sei2 {ECO:0000313|EMBL:AHI47313.1};
RX   PubMed=24412216; DOI=10.1016/j.ympev.2013.12.009;
RA   Vences M., Sanchez E., Hauswaldt J.S., Eikelmann D., Rodriguez A.,
RA   Carranza S., Donaire D., Gehara M., Helfer V., Lotters S., Werner P.,
RA   Schulz S., Steinfartz S.;
RT   "Nuclear and mitochondrial multilocus phylogeny and survey of alkaloid
RT   content in true salamanders of the genus Salamandra (Salamandridae).";
RL   Mol. Phylogenet. Evol. 73:208-216(2014).
CC   -!- FUNCTION: Stimulates the adrenal glands to release cortisol.
CC       {ECO:0000256|ARBA:ARBA00002965}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the POMC family.
CC       {ECO:0000256|ARBA:ARBA00005832}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KF645820; AHI47313.1; -; Genomic_DNA.
DR   AlphaFoldDB; W5ZYM9; -.
DR   GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR   GO; GO:0030141; C:secretory granule; IEA:TreeGrafter.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IEA:TreeGrafter.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:2000852; P:regulation of corticosterone secretion; IEA:TreeGrafter.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR001941; PMOC.
DR   InterPro; IPR050878; POMC-derived_peptides.
DR   PANTHER; PTHR11416; PRO-OPIOMELANOCORTIN; 1.
DR   PANTHER; PTHR11416:SF7; PRO-OPIOMELANOCORTIN; 1.
DR   Pfam; PF00976; ACTH_domain; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Hormone {ECO:0000256|ARBA:ARBA00022702};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          25..63
FT                   /note="Pro-opiomelanocortin/corticotropin ACTH central
FT                   region"
FT                   /evidence="ECO:0000259|SMART:SM01363"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHI47313.1"
FT   NON_TER         82
FT                   /evidence="ECO:0000313|EMBL:AHI47313.1"
SQ   SEQUENCE   82 AA;  9422 MW;  F91938BDDDDB4B3F CRC64;
     ESQSSGAHDS SKEGKGMERQ DNKRSYSMEH FRWGKPVGRK RRPIKVYPNG VEDESSESYP
     LDLKRDLSLG LDYPEYDSQE GL
//