ID W5ZYM9_9SALA Unreviewed; 82 AA. AC W5ZYM9; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 16-APR-2014, sequence version 1. DT 24-JAN-2024, entry version 20. DE SubName: Full=Proopiomelanocortin {ECO:0000313|EMBL:AHI47313.1}; DE Flags: Fragment; GN Name=POMC {ECO:0000313|EMBL:AHI47313.1}; OS Salamandra infraimmaculata infraimmaculata. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Caudata; Salamandroidea; Salamandridae; Salamandrinae; OC Salamandra. OX NCBI_TaxID=353261 {ECO:0000313|EMBL:AHI47313.1}; RN [1] {ECO:0000313|EMBL:AHI47313.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sei2 {ECO:0000313|EMBL:AHI47313.1}; RX PubMed=24412216; DOI=10.1016/j.ympev.2013.12.009; RA Vences M., Sanchez E., Hauswaldt J.S., Eikelmann D., Rodriguez A., RA Carranza S., Donaire D., Gehara M., Helfer V., Lotters S., Werner P., RA Schulz S., Steinfartz S.; RT "Nuclear and mitochondrial multilocus phylogeny and survey of alkaloid RT content in true salamanders of the genus Salamandra (Salamandridae)."; RL Mol. Phylogenet. Evol. 73:208-216(2014). CC -!- FUNCTION: Stimulates the adrenal glands to release cortisol. CC {ECO:0000256|ARBA:ARBA00002965}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the POMC family. CC {ECO:0000256|ARBA:ARBA00005832}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF645820; AHI47313.1; -; Genomic_DNA. DR AlphaFoldDB; W5ZYM9; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR InterPro; IPR013531; Mcrtin_ACTH_cent. DR InterPro; IPR001941; PMOC. DR PANTHER; PTHR11416; PRO-OPIOMELANOCORTIN; 1. DR PANTHER; PTHR11416:SF7; PRO-OPIOMELANOCORTIN; 1. DR Pfam; PF00976; ACTH_domain; 1. DR PRINTS; PR00383; MELANOCORTIN. DR SMART; SM01363; ACTH_domain; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}. FT DOMAIN 25..63 FT /note="Pro-opiomelanocortin/corticotropin ACTH central FT region" FT /evidence="ECO:0000259|SMART:SM01363" FT REGION 1..82 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 11..34 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AHI47313.1" FT NON_TER 82 FT /evidence="ECO:0000313|EMBL:AHI47313.1" SQ SEQUENCE 82 AA; 9422 MW; F91938BDDDDB4B3F CRC64; ESQSSGAHDS SKEGKGMERQ DNKRSYSMEH FRWGKPVGRK RRPIKVYPNG VEDESSESYP LDLKRDLSLG LDYPEYDSQE GL //