ID   W5ZXI0_9SALA            Unreviewed;       112 AA.
AC   W5ZXI0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JUL-2024, entry version 23.
DE   SubName: Full=Chemokine receptor 4 {ECO:0000313|EMBL:AHI47165.1};
DE   Flags: Fragment;
GN   Name=CXCR4 {ECO:0000313|EMBL:AHI47165.1};
OS   Salamandra infraimmaculata infraimmaculata.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Salamandrinae;
OC   Salamandra.
OX   NCBI_TaxID=353261 {ECO:0000313|EMBL:AHI47165.1};
RN   [1] {ECO:0000313|EMBL:AHI47165.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sei2 {ECO:0000313|EMBL:AHI47165.1};
RX   PubMed=24412216; DOI=10.1016/j.ympev.2013.12.009;
RA   Vences M., Sanchez E., Hauswaldt J.S., Eikelmann D., Rodriguez A.,
RA   Carranza S., Donaire D., Gehara M., Helfer V., Lotters S., Werner P.,
RA   Schulz S., Steinfartz S.;
RT   "Nuclear and mitochondrial multilocus phylogeny and survey of alkaloid
RT   content in true salamanders of the genus Salamandra (Salamandridae).";
RL   Mol. Phylogenet. Evol. 73:208-216(2014).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; KF645563; AHI47165.1; -; Genomic_DNA.
DR   AlphaFoldDB; W5ZXI0; -.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0019957; F:C-C chemokine binding; IEA:TreeGrafter.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IEA:TreeGrafter.
DR   GO; GO:0007420; P:brain development; IEA:TreeGrafter.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:TreeGrafter.
DR   GO; GO:0060326; P:cell chemotaxis; IEA:TreeGrafter.
DR   GO; GO:0006955; P:immune response; IEA:TreeGrafter.
DR   GO; GO:0022008; P:neurogenesis; IEA:TreeGrafter.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR050119; GPCR1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AHI47165.1};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..112
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHI47165.1"
FT   NON_TER         112
FT                   /evidence="ECO:0000313|EMBL:AHI47165.1"
SQ   SEQUENCE   112 AA;  12659 MW;  64730915DAE749B7 CRC64;
     IYTVNLYSSV LILAFISLDR YLAIVHATNS QGTRKLLAEK VVYAAVWLPA VLLTVPDFIF
     ASVSLEEGTY QCNHIYPYES REQWTVGFRF VHVTVGFVLP GLVILICYCI II
//