ID W5L372_ASTMX Unreviewed; 475 AA. AC W5L372; DT 16-APR-2014, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 2. DT 02-OCT-2024, entry version 41. DE SubName: Full=Immunoresponsive gene 1, like {ECO:0000313|Ensembl:ENSAMXP00000014284.2}; OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes; OC Characoidei; Characidae; Astyanax. OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000014284.2, ECO:0000313|Proteomes:UP000018467}; RN [1] {ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE. RC STRAIN=female {ECO:0000313|Proteomes:UP000018467}; RA Jeffery W., Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000018467} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=female {ECO:0000313|Proteomes:UP000018467}; RX PubMed=25329095; DOI=10.1038/ncomms6307; RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D., RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E., RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N., RA Yoshizawa M., Warren W.C.; RT "The cavefish genome reveals candidate genes for eye loss."; RL Nat. Commun. 5:5307-5307(2014). RN [3] {ECO:0000313|Ensembl:ENSAMXP00000014284.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- SIMILARITY: Belongs to the PrpD family. CC {ECO:0000256|ARBA:ARBA00006174}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; W5L372; -. DR STRING; 7994.ENSAMXP00000014284; -. DR Ensembl; ENSAMXT00000014284.2; ENSAMXP00000014284.2; ENSAMXG00000013886.2. DR eggNOG; ENOG502QVEB; Eukaryota. DR GeneTree; ENSGT00390000015700; -. DR HOGENOM; CLU_026574_2_2_1; -. DR InParanoid; W5L372; -. DR Proteomes; UP000018467; Unassembled WGS sequence. DR Bgee; ENSAMXG00000013886; Expressed in zone of skin and 6 other cell types or tissues. DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter. DR GO; GO:0047613; F:aconitate decarboxylase activity; IEA:TreeGrafter. DR GO; GO:0090594; P:inflammatory response to wounding; IEA:Ensembl. DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl. DR Gene3D; 1.10.4100.10; 2-methylcitrate dehydratase PrpD; 1. DR Gene3D; 3.30.1330.120; 2-methylcitrate dehydratase PrpD; 1. DR InterPro; IPR036148; MmgE/PrpD_sf. DR InterPro; IPR042183; MmgE/PrpD_sf_1. DR InterPro; IPR042188; MmgE/PrpD_sf_2. DR InterPro; IPR005656; MmgE_PrpD. DR InterPro; IPR045337; MmgE_PrpD_C. DR InterPro; IPR045336; MmgE_PrpD_N. DR PANTHER; PTHR16943; 2-METHYLCITRATE DEHYDRATASE-RELATED; 1. DR PANTHER; PTHR16943:SF14; ZGC:154020; 1. DR Pfam; PF19305; MmgE_PrpD_C; 1. DR Pfam; PF03972; MmgE_PrpD_N; 1. DR SUPFAM; SSF103378; 2-methylcitrate dehydratase PrpD; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000018467}. FT DOMAIN 31..256 FT /note="MmgE/PrpD N-terminal" FT /evidence="ECO:0000259|Pfam:PF03972" FT DOMAIN 289..458 FT /note="MmgE/PrpD C-terminal" FT /evidence="ECO:0000259|Pfam:PF19305" FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 475 AA; 52273 MW; 17E5562949350452 CRC64; TLTSTLTSTT RRQHALQRTA PEETVTSSFG RFIQGVQPSH LSPKVIQRSK RMVTTEVFDL ALQHCQHMYA PDDISFVYGR NGTKLSPTLA AFVNGVAVHS MDFDDTWHPA THPSGAVLPA LLAISDMLPK NSKPRGVDLL LAFNVGIEIQ GRLLRFSNEA RNIPKRFHPP TVVGTMGSAA ACARLLSLDP TQCSNALAIA ASLSGAPMAN AATQSKPLHI GNASRLGLEA ALLASRGLEA SPLILDAVPG VAGFSAFYED YAPQPLPSPE EVEMHSFLLE EQDMAFKRFP AHLGMHWVAD AAATVHKALM DLPIRSISPN MVQDILLRVP HSKYINRPYP ESEHQARHSF QFNACTALLD GEVTVQSFQN EAVLRPELYE LLSRVRVEHP QDNPANFNRM YAEVEVTLVS GDVFRGRCDT FYGHWRNPLS EESLKKKFRN NAGAVLTPDR VDALVQAVDE LEYLDDCTPL LTPLQ //