ID W1XBD7_ECOLX Unreviewed; 813 AA. AC W1XBD7; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 22-FEB-2023, entry version 36. DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982}; DE Flags: Fragment; GN ORFNames=Q609_ECAC00353G0001 {ECO:0000313|EMBL:ETJ27436.1}; OS Escherichia coli DORA_A_5_14_21. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=1403943 {ECO:0000313|EMBL:ETJ27436.1, ECO:0000313|Proteomes:UP000018853}; RN [1] {ECO:0000313|EMBL:ETJ27436.1, ECO:0000313|Proteomes:UP000018853} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DORA_A_5_14_21 {ECO:0000313|Proteomes:UP000018853}; RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J., RA Banfield J.F.; RT "A Varibaculum cambriense genome reconstructed from a premature infant gut RT community with otherwise low bacterial novelty that shifts toward anaerobic RT metabolism during the third week of life."; RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA. CC It is possible that it carries out the mismatch recognition step. This CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}. CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ETJ27436.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AZLZ01000353; ETJ27436.1; -; Genomic_DNA. DR AlphaFoldDB; W1XBD7; -. DR EnsemblBacteria; ETJ27436; ETJ27436; Q609_ECAC00353G0001. DR Proteomes; UP000018853; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro. DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:InterPro. DR CDD; cd03284; ABC_MutS1; 1. DR Gene3D; 1.10.1420.10; -; 2. DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1. DR Gene3D; 3.30.420.110; MutS, connector domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR HAMAP; MF_00096; MutS; 1. DR InterPro; IPR005748; DNA_mismatch_repair_MutS. DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N. DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH. DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C. DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp. DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core. DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N. DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf. DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom. DR InterPro; IPR036678; MutS_con_dom_sf. DR InterPro; IPR045076; MutS_family. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1. DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1. DR Pfam; PF01624; MutS_I; 1. DR Pfam; PF05188; MutS_II; 1. DR Pfam; PF05192; MutS_III; 1. DR Pfam; PF05190; MutS_IV; 1. DR Pfam; PF00488; MutS_V; 1. DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2. DR SMART; SM00534; MUTSac; 1. DR SMART; SM00533; MUTSd; 1. DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1. DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1. DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR TIGRFAMs; TIGR01070; mutS1; 1. DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU003756}. FT DOMAIN 683..699 FT /note="DNA mismatch repair proteins mutS family" FT /evidence="ECO:0000259|PROSITE:PS00486" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ETJ27436.1" FT NON_TER 813 FT /evidence="ECO:0000313|EMBL:ETJ27436.1" SQ SEQUENCE 813 AA; 90809 MW; 258EBAC448C7C01B CRC64; NFDAHTPMMQ QYLKLKAQHP EILLFYRMGD FYELFYDDAK RASQLLDISL TKRGASAGEP IPMAGIPYHA VENYLAKLVN QGESVAICEQ IGDPATSKGP VERKVVRIVT PGTISDEALL QERQDNLLAA IWQDSKGFGY ATLDISSGRF RLSEPADRET MAAELQRTNP AELLYAEDFA EMSLIEGRRG LRRRPLWEFE IDTARQQLNL QFGTRDLVGF GVENAPRGLC AAGCLLQYAK DTQRTTLPHI RSITMEREQD SIIMDAATRR NLEITQNLAG GAENTLASVL DCTVTPMGSR MLKRWLHMPV RDTRVLLERQ QTIGALQDFT AELQPVLRQV GDLERILARL ALRTARPRDL ARMRHAFQQL PELRAQLENV DSAPVQALRE KMGEFAELRD LLERAIIDTP PVLVRDGGVI ASGYNEELDE WRALADGATD YLERLEVRER ERTGLDTLKV GFNAVHGYYI QISRGQSHLA PINYMRRQTL KNAERYIIPE LKEYEDKVLT SKGKALALEK QLYEELFDLL LPHLEALQQS ASALAELDVL VNLAERAYTL NYTCPTFIDK PGIRITEGRH PVVEQVLNEP FIANPLNLSP QRRMLIITGP NMGGKSTYMR QTALIALMAY IGSYVPAQKV EIGPIDRIFT RVGAADDLAS GRSTFMVEMT ETANILHNAT EYSLVLMDEI GRGTSTYDGL SLAWACAENL ANKIKALTLF ATHYFELTQL PEKMEGVANV HLDALEHGDT IAFMHSVQDG AASKSYGLAV AALAGVPKEV IKRARQKLRE LESISPNAAA TQVDGTQMSL LSV //