ID   W0G9Q8_9HEPC            Unreviewed;       114 AA.
AC   W0G9Q8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363062};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363062};
DE   Flags: Fragment;
OS   Hepatitis C virus subtype 1a.
OC   Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
OC   Flaviviridae; Hepacivirus.
OX   NCBI_TaxID=31646 {ECO:0000313|EMBL:AHF51797.1};
RN   [1] {ECO:0000313|EMBL:AHF51797.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H11 {ECO:0000313|EMBL:AHF51797.1};
RX   PubMed=23714239; DOI=10.1186/1743-422X-10-167;
RA   da Silva N.M.O., Germano F.N., Mendoza-Sassi R.A., Seuanez H.N.,
RA   Soares M.A., de Martinez A.M.B.;
RT   "Evidence of association between hepatitis C virus genotype 2b and
RT   nosocomial transmissions in hemodialysis centers from southern
RT   Brazil.";
RL   Virol. J. 10:167-167(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA-
CC         COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557,
CC         ChEBI:CHEBI:83400; EC=2.7.7.48;
CC         Evidence={ECO:0000256|RuleBase:RU363062,
CC         ECO:0000256|SAAS:SAAS01125840};
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DR   EMBL; KC520832; AHF51797.1; -; Genomic_RNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   InterPro; IPR002166; RNA_pol_HCV.
DR   Pfam; PF00998; RdRP_3; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363062,
KW   ECO:0000256|SAAS:SAAS00515117};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363062,
KW   ECO:0000256|SAAS:SAAS00515129};
KW   RNA-directed RNA polymerase {ECO:0000256|RuleBase:RU363062,
KW   ECO:0000256|SAAS:SAAS00515113};
KW   Transferase {ECO:0000256|RuleBase:RU363062,
KW   ECO:0000256|SAAS:SAAS00515114};
KW   Viral RNA replication {ECO:0000256|RuleBase:RU363062,
KW   ECO:0000256|SAAS:SAAS00515121}.
FT   DOMAIN        1    108       RdRp catalytic. {ECO:0000259|PROSITE:
FT                                PS50507}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AHF51797.1}.
FT   NON_TER     114    114       {ECO:0000313|EMBL:AHF51797.1}.
SQ   SEQUENCE   114 AA;  12213 MW;  AF27A0C5EE2528D9 CRC64;
     DSTVTESDIR TEEAIYQCCD LDPQARVAIR SLTERLYVGG PLTNSRGENC GYRRCRASGV
     LTTSCGNTLT CYIKAQAACR AAGLRDCTML VCGDDLVVIC ESAGVQEDAA XLRA
//