ID   V9TVB2_9BETC            Unreviewed;      2685 AA.
AC   V9TVB2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   29-APR-2015, entry version 12.
DE   SubName: Full=Orf1ab {ECO:0000313|EMBL:AHC74097.1};
DE   Flags: Fragment;
GN   Name=orf1ab {ECO:0000313|EMBL:AHC74097.1};
OS   Middle East respiratory syndrome coronavirus.
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales;
OC   Coronaviridae; Coronavirinae; Betacoronavirus;
OC   unclassified Betacoronavirus.
OX   NCBI_TaxID=1335626 {ECO:0000313|EMBL:AHC74097.1};
RN   [1] {ECO:0000313|EMBL:AHC74097.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Qatar4 {ECO:0000313|EMBL:AHC74097.1};
RA   Haagmans B.L., Al-Dhahiry S.H.S., Reusken C.B.E.M., Raj V.S.,
RA   Galiano M., Myers R., Godeke G.-J., Jonges M., Farag E., Diab A.,
RA   Ghobashy H., Alhajri F., Al-Thani M., Al-Marri S.A., Al Romaihi H.E.,
RA   Al Khal A., Bermingham A., Osterhaus A.D.M.E., AlHajri M.M.,
RA   Koopmans M.P.G.;
RT   "Middle East respiratory syndrome coronavirus in dromedary camels: an
RT   outbreak investigation.";
RL   Lancet Infect. Dis. 0:0-0(2013).
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000256|SAAS:SAAS00153520}.
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DR   EMBL; KF961222; AHC74097.1; -; Genomic_RNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR009461; Coronavirus_NSP16.
DR   InterPro; IPR027352; CV_MBD_dom.
DR   InterPro; IPR009466; NSP11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   InterPro; IPR009469; RNA_pol_N_coronovir.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF06478; Corona_RPol_N; 1.
DR   Pfam; PF06471; NSP11; 1.
DR   Pfam; PF06460; NSP13; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51653; CV_MBD; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00180352};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00180363};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00075875};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00153703};
KW   RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00153521};
KW   Transferase {ECO:0000256|SAAS:SAAS00153681}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AHC74097.1}.
SQ   SEQUENCE   2685 AA;  303219 MW;  7638CB81574474A1 CRC64;
     ARIEPCSSGL STDVVFRAFD ICNYKAKVAG IGKYYKTNTC RFVELDDQGH HLDSYFVVKR
     HTMENYELEK HCYDLLRDCD AVAPHDFFIF DVDKVKTPHI VRQRLTEYTM MDLVYALRHF
     DQNSEVLKAI LVKYGCCDVT YFENKLWFDF VENPSVIGVY HKLGERVRQA ILNTVKFCDH
     MVKAGLVGVL TLDNQDLNGK WYDFGDFVIT QPGSGVAIVD SYYSYLMPVL SMTDCLAAET
     HRDCDFNKPL IEWPLTEYDF TDYKVQLFEK YFKYWDQTYH ANCVNCTDDR CVLHCANFNV
     LFAMTMPKTC FGPIVRKIFV DGVPFVVSCG YHYKELGLVM NMDVSLHRHR LSLKELMMYA
     ADPAMHIASS NAFLDLRTSC FSVAALTTGL TFQTVRPGNF NQDFYDFVVS KGFFKEGSSV
     TLKHFFFAQD GNAAITDYNY YSYNLPTMCD IKQMLFCMEV VNKYFEIYDG GCLNASEVVV
     NNLDKSAGHP FNKFGKARVY YESMSYQEQD ELFAMTKRNV IPTMTQMNLK YAISAKNRAR
     TVAGVSILST MTNRQYHQKM LKSMAATRGA TCVIGTTKFY GGWDFMLKTL YKDVDNPHLM
     GWDYPKCDRA MPNMCRIFAS LILARKHGTC CTTRDRFYRL ANECAQVLSE YVLCGGGYYV
     KPGGTSSGDA TTAYANSVFN ILQATTANVS ALMGANGNKI VDKEVKDMQF DLYVNVYRST
     SPDPKFVDKY YAFLNKHFSM MILSDDGVVC YNSDYAAKGY IAGIQNFKET LYYQNNVFMS
     EAKCWVETDL KKGPHEFCSQ HTLYIKDGDD GYFLPYPDPS RILSAGCFVD DIVKTDGTLM
     VERFVSLAID AYPLTKHEDI EYQNVFWVYL QYIEKLYKDL TGHMLDSYSV MLCGDNSAKF
     WEEAFYRDLY SSPTTLQAVG SCVVCHSQTS LRCGTCIRRP FLCCKCCYDH VIATPHKMVL
     SVSPYVCNAP GCGVSDVTKL YLGGMSYFCV DHRPVCSFPL CANGLVFGLY KNMCTGSPSI
     VEFNRLATCD WTESGDYTLA NTTTEPLKLF AAETLRATEE ASKQSYAIAT IKEIVGERQL
     LLVWEAGKSK PPLNRNYVFT GYHITKNSKV QLGEYIFERI DYSDAVSYKS STTYKLTVGD
     IFVLTSHSVA TLTAPTIVNQ ERYVKITGLY PTITVPEEFA SHVANFQKSG YSKYVTVQGP
     PGTGKSHFAI GLAIYYPTAR VVYTACSHAA VDALCEKAFK YLNIAKCSRI IPAKARVECY
     DRFKVNETNS QYLFSTINAL PETSADILVV DEVSMCTNYD LSIINARIKA KHIVYVGDPA
     QLPAPRTLLT RGTLEPENFN SVTRLMCNLG PDIFLSMCYR CPKEIVSTVS ALVYNNKLLA
     KKELSGQCFK ILYKGNVTHD ASSAINRPQL TFVKNFITAN PAWSKAVFIS PYNSQNAVAR
     SMLGLTTQTV DSSQGSEYQY VIFCQTADTA HANNINRFNV AITRAQKGIL CVMTSQALFE
     SLEFTELSFT NYKLQSQIVT GLFKDCSRET SGLSPAYAPT YVSVDDKYKT SDELCVNLNL
     PANVPYSRVI SRMGFKLDAT VPGYPKLFIT REEAVRQVRS WIGFDVEGAH ASRNACGTNV
     PLQLGFSTGV NFVVQPVGVV DTEWGNMLTG IAARPPPGEQ FKHLVPLMHK GAAWPIVRRR
     IVQMLSDTLD KLSDYCTFVC WAHGFELTSA SYFCKIGKEQ KCCMCNRRAA AYSSPLQSYA
     CWTHSCGYDY VYNPFFVDVQ QWGYVGNLAT NHDRYCSVHQ GAHVASNDAI MTRCLAIHSC
     FIERVDWDIE YPYISHEKKL NSCCRIVERN VVRAALLAGS FDKVYDIGNP KGIPIVDDPV
     VDWHYFDAQP LTRKVQQLFY TEDMASRFAD GLCLFWNCNV PKYPNNAIVC RFDTRVHSEF
     NLPGCDGGSL YVNKHAFHTP AYDVSAFRDL KPLPFFYYST TPCEVHGNGS MIEDIDYVPL
     KSAVCITTCN LGGAVCRKHA TEYREYMEAY NLVSASGFRL WCYKTFDIYN LWSTFTKVQG
     LENIAFNVVK QGHFIGVEGE LPVAVVNDKI FTKSGVNDIC MFENKTTLPT NIAFELYAKR
     AVRSHPDFKL LHNLQADICY KFVLWDYERS NIYGTATIGV CKYTDIDVNS ALNICFDIRD
     NGSLEKFMST PNAIFISDRK IKKYPCMVGP DYAYFNGAII RDSDVVKQPV KFYLYKKVNN
     EFIDPTECIY TQSRSCSDFL PLSDMEKDFL SFDSDVFIKK YGLENYAFEH VVYGDFSHTT
     LGGLHLLIGL YKKQQEGHII MEEMLKGSST IHNYFITETN TAAFKAVCSV IDLKLDDFVM
     ILKSQDLGVV SKVVKVPIDL TMIEFMLWCK DGQVQTFYPR LQASADWKPG HAMPSLFKVQ
     NVNLERCELA NYKQSIPMPR GVHMNIAKYM QLCQYLNTCT LAVPANMRVI HFGAGSDKGI
     APGTSVLRQW LPIDAIIIDN DLNEFVSDAD ITLFGDCVTV RVGQQVDLVI SDMYDPTTKN
     VTGSNESKAL FFTYLCNLIN NNLALGGSVA IKITEHSWSV ELYELMGKFA WWTVFCTNAN
     ASSSEGFLLG INYLGTIKEN IDGGAMHANY IFWRNSTPMN LSTYSLFDLS KFQLKLKGTP
     VLQLKESQIN ELVISLLSQG KLLIRDNDTL SVSTDVLVNT YRKLR
//