ID UL128_HCMVM Reviewed; 171 AA. AC V9LLX6; DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2017, sequence version 1. DT 11-DEC-2019, entry version 6. DE RecName: Full=Envelope protein UL128; GN Name=UL128; OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5). OC Viruses; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=295027; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Davison A.J.; RT "Human cytomegalovirus RL11 gene family: variation, recombination and RT transcription."; RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases. RN [2] RP FUNCTION, AND INTERACTION WITH GH; GL; UL130 AND UL131A. RX PubMed=17942555; DOI=10.1128/jvi.01910-07; RA Ryckman B.J., Rainish B.L., Chase M.C., Borton J.A., Nelson J.A., RA Jarvis M.A., Johnson D.C.; RT "Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that RT mediates entry into epithelial and endothelial cells."; RL J. Virol. 82:60-70(2008). RN [3] RP FUNCTION. RX PubMed=21367908; DOI=10.1128/jvi.02100-10; RA Straschewski S., Patrone M., Walther P., Gallina A., Mertens T., RA Frascaroli G.; RT "Protein pUL128 of human cytomegalovirus is necessary for monocyte RT infection and blocking of migration."; RL J. Virol. 85:5150-5158(2011). RN [4] RP FUNCTION. RX PubMed=23853586; DOI=10.1371/journal.ppat.1003463; RA Nogalski M.T., Chan G.C., Stevenson E.V., Collins-McMillen D.K., RA Yurochko A.D.; RT "The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation RT required for efficient viral internalization into target monocytes."; RL PLoS Pathog. 9:E1003463-E1003463(2013). RN [5] RP SUBCELLULAR LOCATION. RX PubMed=23804643; DOI=10.1128/jvi.01167-13; RA Zhou M., Yu Q., Wechsler A., Ryckman B.J.; RT "Comparative analysis of gO isoforms reveals that strains of human RT cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the RT virion envelope."; RL J. Virol. 87:9680-9690(2013). RN [6] RP REVIEW. RX PubMed=24957713; RA Tao R., Xu J., Gao H., Zhao W., Shang S.; RT "Characteristics and functions of human cytomegalovirus UL128 RT gene/protein."; RL Acta Virol. 58:103-107(2014). RN [7] RP FUNCTION, AND INTERACTION WITH HOST NRP2. RX PubMed=30057110; DOI=10.1016/j.cell.2018.06.028; RA Martinez-Martin N., Marcandalli J., Huang C.S., Arthur C.P., Perotti M., RA Foglierini M., Ho H., Dosey A.M., Shriver S., Payandeh J., Leitner A., RA Lanzavecchia A., Perez L., Ciferri C.; RT "An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a RT Central Viral Receptor."; RL Cell 0:0-0(2018). CC -!- FUNCTION: Plays a role in viral entry into host cells. Forms a CC pentameric complex at the surface of the viral envelope together with CC gH, gL, UL130 and UL131. This complex is required for entry in CC epithelial, endothelial and myeloid host cells (PubMed:23853586, CC PubMed:17942555). Mechanistically, engages host receptor(s) including CC neurophilin 2/NRP2 to mediate infection (PubMed:30057110). CC Additionally, monomeric UL128 may interfere with certain inflammatory CC cytokines to increase infection and dissemination by blocking monocytes CC migration (PubMed:21367908). {ECO:0000269|PubMed:17942555, CC ECO:0000269|PubMed:21367908, ECO:0000269|PubMed:23853586, CC ECO:0000269|PubMed:30057110}. CC -!- SUBUNIT: Forms the envelope pentamer complex (PC) composed of gH, gL, CC UL128, UL130, and UL131A (PubMed:17942555). The pentamer interacts with CC host NRP2 (PubMed:30057110). {ECO:0000269|PubMed:17942555, CC ECO:0000269|PubMed:30057110}. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:23804643}. CC Note=Found as a pentameric complex at the surface of virion envelope. CC {ECO:0000269|PubMed:23804643}. CC -!- SIMILARITY: Belongs to the HHV-5 UL128 protein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JX512197; AFR54607.1; -; Genomic_DNA. DR Proteomes; UP000169440; Genome. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. PE 1: Evidence at protein level; KW Host-virus interaction; Membrane; Viral attachment to host cell; KW Viral attachment to host entry receptor; Viral envelope protein; Virion; KW Virus entry into host cell. FT CHAIN 1..171 FT /note="Envelope protein UL128" FT /id="PRO_0000445468" SQ SEQUENCE 171 AA; 19773 MW; 9973D2EF8BF282ED CRC64; MSPKNLTPFL TALWLLLDHS RVPRVRAEEC CEFINVNHPP ERCYDFKMCN RFTVALRCPD GEVCYSPEKT AEIRGIVTTM THSLTRQVVH NKLTSCNYNP LYLEADGRIR CGKVNDKAQY LLGAAGSVPY RWINLEYDKI TRIVGLNQYL ESVKKHKRLD VCRAKMGYML Q //