ID V9HWI5_HUMAN Unreviewed; 166 AA. AC V9HWI5; DT 19-MAR-2014, integrated into UniProtKB/TrEMBL. DT 19-MAR-2014, sequence version 1. DT 24-JUL-2024, entry version 78. DE RecName: Full=Cofilin-1 {ECO:0000256|ARBA:ARBA00015284}; DE AltName: Full=Cofilin, non-muscle isoform {ECO:0000256|ARBA:ARBA00030239}; GN Name=HEL-S-15 {ECO:0000313|EMBL:ACJ13657.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACJ13657.1}; RN [1] {ECO:0000313|EMBL:ACJ13657.1} RP NUCLEOTIDE SEQUENCE. RA Li J.Y., Wang H.Y., Liu F.J., Liu J.; RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium membrane CC {ECO:0000256|ARBA:ARBA00004588}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004588}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004588}. Cell projection, ruffle membrane CC {ECO:0000256|ARBA:ARBA00004599}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004599}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004599}. CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. CC {ECO:0000256|ARBA:ARBA00006844}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU794603; ACJ13657.1; -; mRNA. DR RefSeq; NP_005498.1; NM_005507.2. DR AlphaFoldDB; V9HWI5; -. DR SMR; V9HWI5; -. DR IntAct; V9HWI5; 2. DR Antibodypedia; 16010; 1090 antibodies from 42 providers. DR DNASU; 1072; -. DR GeneID; 1072; -. DR KEGG; hsa:1072; -. DR UCSC; uc001ofs.4; human. DR CTD; 1072; -. DR DisGeNET; 1072; -. DR VEuPathDB; HostDB:ENSG00000172757; -. DR OMA; WSMIYAT; -. DR OrthoDB; 3380386at2759; -. DR BioGRID-ORCS; 1072; 429 hits in 1163 CRISPR screens. DR ChiTaRS; CFL1; human. DR ExpressionAtlas; V9HWI5; baseline and differential. DR GO; GO:0030479; C:actin cortical patch; IEA:TreeGrafter. DR GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter. DR GO; GO:0030043; P:actin filament fragmentation; IEA:TreeGrafter. DR GO; GO:0051014; P:actin filament severing; IEA:TreeGrafter. DR GO; GO:0000281; P:mitotic cytokinesis; IEA:TreeGrafter. DR CDD; cd11286; ADF_cofilin_like; 1. DR Gene3D; 3.40.20.10; Severin; 1. DR InterPro; IPR002108; ADF-H. DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf. DR InterPro; IPR017904; ADF/Cofilin. DR PANTHER; PTHR11913:SF17; COFILIN-1; 1. DR PANTHER; PTHR11913; COFILIN-RELATED; 1. DR Pfam; PF00241; Cofilin_ADF; 1. DR PRINTS; PR00006; COFILIN. DR SMART; SM00102; ADF; 1. DR SUPFAM; SSF55753; Actin depolymerizing proteins; 1. DR PROSITE; PS51263; ADF_H; 1. PE 2: Evidence at transcript level; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}. FT DOMAIN 4..153 FT /note="ADF-H" FT /evidence="ECO:0000259|PROSITE:PS51263" SQ SEQUENCE 166 AA; 18502 MW; 589EF8FC1EC13719 CRC64; MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL //