ID   V9GYK3_HUMAN            Unreviewed;       117 AA.
AC   V9GYK3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   29-MAY-2024, entry version 47.
DE   SubName: Full=Glucosamine-6-phosphate deaminase 2 {ECO:0000313|Ensembl:ENSP00000476853.1};
DE   Flags: Fragment;
GN   Name=GNPDA2 {ECO:0000313|Ensembl:ENSP00000476853.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000476853.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000476853.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000476853.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2024) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-
CC         phosphate + NH4(+); Xref=Rhea:RHEA:12172, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:28938, ChEBI:CHEBI:57634, ChEBI:CHEBI:75989; EC=3.5.99.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000644};
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DR   EMBL; AC096586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MassIVE; V9GYK3; -.
DR   MaxQB; V9GYK3; -.
DR   PeptideAtlas; V9GYK3; -.
DR   Antibodypedia; 23728; 144 antibodies from 28 providers.
DR   Ensembl; ENST00000609092.5; ENSP00000476853.1; ENSG00000163281.12.
DR   UCSC; uc062wia.1; human.
DR   HGNC; HGNC:21526; GNPDA2.
DR   VEuPathDB; HostDB:ENSG00000163281; -.
DR   GeneTree; ENSGT00390000014316; -.
DR   HOGENOM; CLU_049611_3_0_1; -.
DR   ChiTaRS; GNPDA2; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000163281; Expressed in secondary oocyte and 146 other cell types or tissues.
DR   ExpressionAtlas; V9GYK3; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0004342; F:glucosamine-6-phosphate deaminase activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:TreeGrafter.
DR   GO; GO:0006043; P:glucosamine catabolic process; IEA:TreeGrafter.
DR   GO; GO:0006046; P:N-acetylglucosamine catabolic process; IEA:TreeGrafter.
DR   GO; GO:0019262; P:N-acetylneuraminate catabolic process; IEA:TreeGrafter.
DR   Gene3D; 3.40.50.1360; -; 1.
DR   InterPro; IPR004547; Glucosamine6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR11280; GLUCOSAMINE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11280:SF5; GLUCOSAMINE-6-PHOSPHATE ISOMERASE; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:V9GYK3,
KW   ECO:0007829|MaxQB:V9GYK3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000476853.1"
SQ   SEQUENCE   117 AA;  13120 MW;  3426032E035F5866 CRC64;
     XGDLSKVPTM ALTVGVGTVM DAREVMILIT GAHKAFALYK AIEEGVNHMW TVSAFQQHPR
     TIFVCDEDAT LELRVKTVKY FKEMALSYHK LIQENYLLNS VQGCASKARK KFATVWA
//