ID V9GX11_MOUSE Unreviewed; 192 AA. AC V9GX11; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 22-FEB-2023, entry version 56. DE SubName: Full=Cytochrome b-561 {ECO:0000313|Ensembl:ENSMUSP00000138931.2}; GN Name=Cyb561 {ECO:0000313|Ensembl:ENSMUSP00000138931.2, GN ECO:0000313|MGI:MGI:103253}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000138931.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000138931.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138931.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000138931.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138931.2}; RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC -!- COFACTOR: CC Name=heme b; Xref=ChEBI:CHEBI:60344; CC Evidence={ECO:0000256|ARBA:ARBA00001970}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006532197.1; XM_006532134.3. DR AlphaFoldDB; V9GX11; -. DR SMR; V9GX11; -. DR Antibodypedia; 18653; 87 antibodies from 17 providers. DR DNASU; 13056; -. DR Ensembl; ENSMUST00000184086.8; ENSMUSP00000138931.2; ENSMUSG00000019590.17. DR GeneID; 13056; -. DR AGR; MGI:103253; -. DR CTD; 1534; -. DR MGI; MGI:103253; Cyb561. DR VEuPathDB; HostDB:ENSMUSG00000019590; -. DR GeneTree; ENSGT00950000183197; -. DR HOGENOM; CLU_069712_3_1_1; -. DR OrthoDB; 2877457at2759; -. DR BioGRID-ORCS; 13056; 0 hits in 79 CRISPR screens. DR ChiTaRS; Cyb561; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000019590; Expressed in choroid plexus of fourth ventricle and 237 other tissues. DR ExpressionAtlas; V9GX11; baseline and differential. DR GO; GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR Gene3D; 1.20.120.1770; -; 1. DR InterPro; IPR043205; CYB561/CYBRD1-like. DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM. DR PANTHER; PTHR10106; CYTOCHROME B561-RELATED; 1. DR PANTHER; PTHR10106:SF14; TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561; 1. DR Pfam; PF03188; Cytochrom_B561; 1. DR SMART; SM00665; B561; 1. DR PROSITE; PS50939; CYTOCHROME_B561; 1. PE 4: Predicted; KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00022617}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022617}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..36 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 56..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 86..105 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 117..133 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 18..192 FT /note="Cytochrome b561" FT /evidence="ECO:0000259|PROSITE:PS50939" SQ SEQUENCE 192 AA; 21009 MW; 497A84EB2A42CBE7 CRC64; MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALVG LVAVFDYHKK KGYADLYSLH SWCGILVFVL YFVQVPASSW LSRALSPFSG SWVSASSCSL ELHSLCGAAT ALSTFSLVPP SSSSLWAQPY WA //