ID V9GWU6_MOUSE Unreviewed; 99 AA. AC V9GWU6; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 22-FEB-2023, entry version 50. DE SubName: Full=Cytochrome b-561 {ECO:0000313|Ensembl:ENSMUSP00000138838.2}; DE Flags: Fragment; GN Name=Cyb561 {ECO:0000313|Ensembl:ENSMUSP00000138838.2, GN ECO:0000313|MGI:MGI:103253}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000138838.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000138838.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138838.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000138838.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138838.2}; RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC -!- COFACTOR: CC Name=heme b; Xref=ChEBI:CHEBI:60344; CC Evidence={ECO:0000256|ARBA:ARBA00001970}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; V9GWU6; -. DR SMR; V9GWU6; -. DR Antibodypedia; 18653; 87 antibodies from 17 providers. DR Ensembl; ENSMUST00000150563.3; ENSMUSP00000138838.2; ENSMUSG00000019590.17. DR AGR; MGI:103253; -. DR MGI; MGI:103253; Cyb561. DR VEuPathDB; HostDB:ENSMUSG00000019590; -. DR GeneTree; ENSGT00950000183197; -. DR OMA; SYLPIHV; -. DR ChiTaRS; Cyb561; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000019590; Expressed in choroid plexus of fourth ventricle and 237 other tissues. DR ExpressionAtlas; V9GWU6; baseline and differential. DR GO; GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR Gene3D; 1.20.120.1770; -; 1. DR InterPro; IPR043205; CYB561/CYBRD1-like. DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM. DR PANTHER; PTHR10106; CYTOCHROME B561-RELATED; 1. DR PANTHER; PTHR10106:SF14; TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561; 1. DR Pfam; PF03188; Cytochrom_B561; 1. DR PROSITE; PS50939; CYTOCHROME_B561; 1. PE 4: Predicted; KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00022617}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022617}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..36 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 56..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 81..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 18..99 FT /note="Cytochrome b561" FT /evidence="ECO:0000259|PROSITE:PS50939" FT NON_TER 99 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000138838.2" SQ SEQUENCE 99 AA; 10933 MW; 656FA0B3B6BDA902 CRC64; MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALV //