ID V9GWU6_MOUSE Unreviewed; 99 AA. AC V9GWU6; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 07-APR-2021, entry version 42. DE RecName: Full=Cytochrome b-561 {ECO:0000256|ARBA:ARBA00017878}; DE AltName: Full=Cytochrome b561 {ECO:0000256|ARBA:ARBA00014975}; DE Flags: Fragment; GN Name=Cyb561 {ECO:0000313|Ensembl:ENSMUSP00000138838, GN ECO:0000313|MGI:MGI:103253}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000138838, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000138838, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138838, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000138838} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138838}; RG Ensembl; RL Submitted (DEC-2013) to UniProtKB. CC -!- FUNCTION: Secretory vesicle-specific electron transport protein. CC {ECO:0000256|ARBA:ARBA00002079}. CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane CC {ECO:0000256|ARBA:ARBA00004638}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004638}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL596246; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; V9GWU6; -. DR ProteomicsDB; 320996; -. DR Antibodypedia; 18653; 87 antibodies. DR Ensembl; ENSMUST00000150563; ENSMUSP00000138838; ENSMUSG00000019590. DR MGI; MGI:103253; Cyb561. DR GeneTree; ENSGT00950000183197; -. DR OMA; FRNESKR; -. DR ChiTaRS; Cyb561; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000019590; Expressed in choroid plexus of fourth ventricle and 289 other tissues. DR ExpressionAtlas; V9GWU6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000293; F:ferric-chelate reductase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0022900; P:electron transport chain; IEA:InterPro. DR InterPro; IPR043205; CYB561/CYBRD1-like. DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM. DR InterPro; IPR028837; Cytochrome_b561. DR PANTHER; PTHR10106; PTHR10106; 1. DR PANTHER; PTHR10106:SF14; PTHR10106:SF14; 1. DR Pfam; PF03188; Cytochrom_B561; 1. DR PROSITE; PS50939; CYTOCHROME_B561; 1. PE 4: Predicted; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..36 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 56..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 81..98 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 18..99 FT /note="Cytochrome b561" FT /evidence="ECO:0000259|PROSITE:PS50939" FT NON_TER 99 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000138838" SQ SEQUENCE 99 AA; 10933 MW; 656FA0B3B6BDA902 CRC64; MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALV //