ID   V5VCW7_ACIBA            Unreviewed;       275 AA.
AC   V5VCW7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-APR-2020, entry version 67.
DE   RecName: Full=Methionine aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
DE            Short=MAP {ECO:0000256|HAMAP-Rule:MF_01974};
DE            Short=MetAP {ECO:0000256|HAMAP-Rule:MF_01974};
DE            EC=3.4.11.18 {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
DE   AltName: Full=Peptidase M {ECO:0000256|HAMAP-Rule:MF_01974};
GN   Name=map {ECO:0000256|HAMAP-Rule:MF_01974,
GN   ECO:0000313|EMBL:PZM18289.1};
GN   Synonyms=map1 {ECO:0000313|EMBL:AKA30982.1}, map_1
GN   {ECO:0000313|EMBL:KZA22651.1}, map_2 {ECO:0000313|EMBL:SST23566.1};
GN   ORFNames=A7M79_08180 {ECO:0000313|EMBL:OIH08354.1}, A7M90_04815
GN   {ECO:0000313|EMBL:OIG72371.1}, A9843_08115
GN   {ECO:0000313|EMBL:OBN25659.1}, AA954_01865
GN   {ECO:0000313|EMBL:OBR20017.1}, ABCAM1_2591
GN   {ECO:0000313|EMBL:QEY04997.1}, ABUW_1234
GN   {ECO:0000313|EMBL:AKA30982.1}, APD33_02645
GN   {ECO:0000313|EMBL:KQE07355.1}, APD33_12805
GN   {ECO:0000313|EMBL:KQE03489.1}, B4R90_02870
GN   {ECO:0000313|EMBL:OVL12321.1}, B9X95_11705
GN   {ECO:0000313|EMBL:OTM85450.1}, BGC29_02575
GN   {ECO:0000313|EMBL:ODP71121.1}, C2U32_08280
GN   {ECO:0000313|EMBL:AUT38008.1}, CEJ64_04655
GN   {ECO:0000313|EMBL:PAM52585.1}, CHQ89_03925
GN   {ECO:0000313|EMBL:OZT31344.1}, CPI82_15740
GN   {ECO:0000313|EMBL:PHQ01666.1}, CSB70_2491
GN   {ECO:0000313|EMBL:AVI33300.1}, DLI69_16830
GN   {ECO:0000313|EMBL:QFV04791.1}, DOL94_04640
GN   {ECO:0000313|EMBL:PZM18289.1}, E2533_16370
GN   {ECO:0000313|EMBL:TEX13795.1}, E2536_05045
GN   {ECO:0000313|EMBL:TEX30240.1}, E5294_06205
GN   {ECO:0000313|EMBL:TGZ07088.1}, E5979_19040
GN   {ECO:0000313|EMBL:TGY98765.1}, EA685_09240
GN   {ECO:0000313|EMBL:RSR10093.1}, EA706_00955
GN   {ECO:0000313|EMBL:RSQ49839.1}, EA722_08630
GN   {ECO:0000313|EMBL:RSP76616.1}, EA746_001715
GN   {ECO:0000313|EMBL:THJ60216.1}, EKS29_06595
GN   {ECO:0000313|EMBL:RTY10994.1}, EWO92_05210
GN   {ECO:0000313|EMBL:RYL18680.1}, EWO96_05210
GN   {ECO:0000313|EMBL:RYL31564.1}, EWP49_05205
GN   {ECO:0000313|EMBL:RYL46242.1}, FD887_09880
GN   {ECO:0000313|EMBL:TLT63582.1}, FD913_06295
GN   {ECO:0000313|EMBL:TLT67225.1}, FJU36_01850
GN   {ECO:0000313|EMBL:TPU81270.1}, FJU42_15260
GN   {ECO:0000313|EMBL:TPU61657.1}, FJU76_01715
GN   {ECO:0000313|EMBL:TPS97919.1}, FJU79_05820
GN   {ECO:0000313|EMBL:TPS87062.1}, FJU87_03675
GN   {ECO:0000313|EMBL:TPU23229.1}, FJV14_00180
GN   {ECO:0000313|EMBL:TPS05618.1}, FR761_12845
GN   {ECO:0000313|EMBL:QFH46123.1}, LV38_03303
GN   {ECO:0000313|EMBL:KZA22651.1}, NCTC13305_03581
GN   {ECO:0000313|EMBL:SUU32078.1}, NCTC13420_00362
GN   {ECO:0000313|EMBL:SUU43619.1}, SAMEA104305318_02021
GN   {ECO:0000313|EMBL:SST23566.1}, SAMEA104305351_02247
GN   {ECO:0000313|EMBL:SSU74255.1};
OS   Acinetobacter baumannii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter;
OC   Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470 {ECO:0000313|EMBL:PZM18289.1, ECO:0000313|Proteomes:UP000248662};
RN   [1] {ECO:0000313|EMBL:AKA30982.1, ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA30982.1,
RC   ECO:0000313|Proteomes:UP000032746};
RX   PubMed=25845845;
RA   Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., Held K.G.,
RA   Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.;
RT   "Resources for Genetic and Genomic Analysis of Emerging Pathogen
RT   Acinetobacter baumannii.";
RL   J. Bacteriol. 197:2027-2035(2015).
RN   [2] {ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746};
RA   Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., Radey M.R.,
RA   Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KQE03489.1, ECO:0000313|Proteomes:UP000051449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABBL072 {ECO:0000313|EMBL:KQE03489.1,
RC   ECO:0000313|Proteomes:UP000051449};
RA   Ozer E.A., Fitzpatrick M.A., Hauser A.R.;
RT   "The utility of whole genome sequencing in characterizing Acinetobacter
RT   epidemiology and analyzing hospital outbreaks.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OBR20017.1, ECO:0000313|Proteomes:UP000078586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3AC14-8 {ECO:0000313|EMBL:OBR20017.1,
RC   ECO:0000313|Proteomes:UP000078586};
RA   Martinez T., Ropelewski A., Mendez R.G., Vazquez G., Robledo I.;
RT   "Draft Genome Sequence of a Multidrug-Resistant KPC-Producing Acinetobacter
RT   baumannii ST2 Isolate from Puerto Rico.";
RL   Genome Announc. 0:0-0(2016).
RN   [5] {ECO:0000313|EMBL:OBR20017.1, ECO:0000313|Proteomes:UP000078586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3AC14-8 {ECO:0000313|EMBL:OBR20017.1,
RC   ECO:0000313|Proteomes:UP000078586};
RX   PubMed=27259867; DOI=10.1099/jmm.0.000289;
RA   Martinez T., Martinez I., Vazquez G.J., Aquino E.E., Robledo I.E.;
RT   "Genetic environment of the KPC gene in Acinetobacter baumannii ST2 clone
RT   from Puerto Rico and genomic insights into its drug resistance.";
RL   J. Med. Microbiol. 65:784-792(2016).
RN   [6] {ECO:0000313|EMBL:KZA22651.1, ECO:0000313|Proteomes:UP000076314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB3638 {ECO:0000313|EMBL:KZA22651.1,
RC   ECO:0000313|Proteomes:UP000076314};
RA   Arivett B.A., Fiester S.E., Ream D.C., Actis L.A.;
RT   "Draft sequences of Acinetobacter baumannii isolates from wounded military
RT   personnel.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:OIG72371.1, ECO:0000313|Proteomes:UP000179791, ECO:0000313|Proteomes:UP000179937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XH639 {ECO:0000313|EMBL:OIH08354.1,
RC   ECO:0000313|Proteomes:UP000179791}, and XH647
RC   {ECO:0000313|EMBL:OIG72371.1, ECO:0000313|Proteomes:UP000179937};
RA   Hua X., Yu Y.;
RT   "The evolution of Acinetobacter baumannii in vivo.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:OBN25659.1, ECO:0000313|Proteomes:UP000093852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABUH754 {ECO:0000313|EMBL:OBN25659.1,
RC   ECO:0000313|Proteomes:UP000093852};
RA   Adams M., Sanka R., Sutton G., Wright M., Jacobs M., Bonomo R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ODP71121.1, ECO:0000313|Proteomes:UP000094982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XH198 {ECO:0000313|EMBL:ODP71121.1,
RC   ECO:0000313|Proteomes:UP000094982};
RA   Mu X., Wang N., Li X., Shi K., Zhou Z., Yu Y., Hua X.;
RT   "The effect of colistin resistance-associated mutations on the fitness of
RT   Acinetobacter baumannii.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:OVL12321.1, ECO:0000313|Proteomes:UP000195460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABUH557 {ECO:0000313|EMBL:OVL12321.1,
RC   ECO:0000313|Proteomes:UP000195460};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:OTM85450.1, ECO:0000313|Proteomes:UP000194699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR350 {ECO:0000313|EMBL:OTM85450.1,
RC   ECO:0000313|Proteomes:UP000194699};
RA   Song R., Chenine A.L., Ruprecht R.M.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:PAM52585.1, ECO:0000313|Proteomes:UP000215800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB79 {ECO:0000313|EMBL:PAM52585.1,
RC   ECO:0000313|Proteomes:UP000215800};
RA   Chen Q.;
RT   "Carbapenem-resistant Acinetobacter baumannii strains.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:OZT31344.1, ECO:0000313|Proteomes:UP000216874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DR1 {ECO:0000313|EMBL:OZT31344.1,
RC   ECO:0000313|Proteomes:UP000216874};
RA   Srinivasan V.B., Rajamohan G.;
RT   "Genome sequence, assembly and annotation.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:PHQ01666.1, ECO:0000313|Proteomes:UP000223291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=I43 {ECO:0000313|EMBL:PHQ01666.1,
RC   ECO:0000313|Proteomes:UP000223291};
RA   Siqueira K.A., Mello I.S., Mendes T.A., Soares M.A.;
RT   "Draft genome of Acinetobacter baumannii strain I43, a mercury resistant
RT   bacteria.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [16] {ECO:0000313|EMBL:AUT38008.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38008.1};
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:AUT38008.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38008.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:AVI33300.1, ECO:0000313|Proteomes:UP000257523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR_0070 {ECO:0000313|EMBL:AVI33300.1,
RC   ECO:0000313|Proteomes:UP000257523};
RA   Benahmed F.H., Lutgring J.D., Yoo B., Machado M., Brown A., McAllister G.,
RA   Perry A., Halpin A.L., Vavikolanu K., Ott S., Zhao X., Tallon L.,
RA   Sadzewicz L., Aluvathingal J., Nadendla S., Voskania-kordi A., Simonyan V.,
RA   Patel J., Shawar R.M.;
RT   "FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|EMBL:PZM18289.1, ECO:0000313|Proteomes:UP000248662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R10 {ECO:0000313|EMBL:PZM18289.1,
RC   ECO:0000313|Proteomes:UP000248662};
RA   Bonnin R.A., Levy M., Cuzon G., Dortet L., Naas T.;
RT   "Carbapenemase-producing Acinetobacter spp. from environmental sources in
RT   an hospital from French Polynesia.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:SUU32078.1, ECO:0000313|Proteomes:UP000254993, ECO:0000313|Proteomes:UP000255154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13305 {ECO:0000313|EMBL:SUU32078.1,
RC   ECO:0000313|Proteomes:UP000255154}, and NCTC13420
RC   {ECO:0000313|EMBL:SUU43619.1, ECO:0000313|Proteomes:UP000254993};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:SST23566.1, ECO:0000313|Proteomes:UP000252694, ECO:0000313|Proteomes:UP000253591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY7045823 {ECO:0000313|EMBL:SST23566.1,
RC   ECO:0000313|Proteomes:UP000252694}, and 4300STDY7045856
RC   {ECO:0000313|EMBL:SSU74255.1, ECO:0000313|Proteomes:UP000253591};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000213|PDB:6MRF}
RP   X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 12-272.
RA   Edwards T.E., Mayclin S.J., Lorimer D.D., Horanyi P.S.,
RA   Seattle Structural Genomics Center for Infectious Disease.;
RT   "Crystal structure of a Methionine aminopeptidase MetAP from Acinetobacter
RT   baumannii.";
RL   Submitted (OCT-2018) to the PDB data bank.
RN   [24] {ECO:0000313|Proteomes:UP000269597, ECO:0000313|Proteomes:UP000271711, ECO:0000313|Proteomes:UP000272401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TG22168 {ECO:0000313|EMBL:RSQ49839.1,
RC   ECO:0000313|Proteomes:UP000272401}, TG31299
RC   {ECO:0000313|EMBL:RSP76616.1, ECO:0000313|Proteomes:UP000269597},
RC   TG31307 {ECO:0000313|Proteomes:UP000280982}, and TG41016
RC   {ECO:0000313|EMBL:RSR10093.1, ECO:0000313|Proteomes:UP000271711};
RA   Sahl J.W.;
RT   "GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance
RT   in Acinetobacter baumannii.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:THJ60216.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TG31307 {ECO:0000313|EMBL:THJ60216.1};
RA   Sahl J.W.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:RTY10994.1, ECO:0000313|Proteomes:UP000278858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM107 {ECO:0000313|EMBL:RTY10994.1,
RC   ECO:0000313|Proteomes:UP000278858};
RA   Fouts D.E., Sutton G., Singh I., Nguyen K.;
RT   "Na.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|Proteomes:UP000291489, ECO:0000313|Proteomes:UP000292081, ECO:0000313|Proteomes:UP000292122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C1T1-1 {ECO:0000313|EMBL:RYL46242.1,
RC   ECO:0000313|Proteomes:UP000291489}, C1T1-2_b
RC   {ECO:0000313|EMBL:RYL31564.1, ECO:0000313|Proteomes:UP000292081}, and
RC   C1T1-3 {ECO:0000313|EMBL:RYL18680.1,
RC   ECO:0000313|Proteomes:UP000292122};
RA   Rehman M.A.;
RT   "Whole-Genome Sequences of Acinetobacter spp Isolated From Dairy Cow
RT   Manure.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:TEX13795.1, ECO:0000313|Proteomes:UP000297480, ECO:0000313|Proteomes:UP000297782}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MDR-CQB {ECO:0000313|EMBL:TEX13795.1,
RC   ECO:0000313|Proteomes:UP000297782}, and MDR-CQE
RC   {ECO:0000313|EMBL:TEX30240.1, ECO:0000313|Proteomes:UP000297480};
RA   Jian Z.;
RT   "Resequencing Analysis and Multi-drug Resistance Differences of
RT   Acinetobacter baumannii in Chongqing, China.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|EMBL:TGZ07088.1, ECO:0000313|Proteomes:UP000307835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DMC-32a {ECO:0000313|EMBL:TGZ07088.1,
RC   ECO:0000313|Proteomes:UP000307835};
RA   Jahan M.I., Hossain M.A., Sultana M.;
RT   "Complete genome of Acinetobacter baumannii.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:TGY98765.1, ECO:0000313|Proteomes:UP000310129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ab5038 {ECO:0000313|EMBL:TGY98765.1,
RC   ECO:0000313|Proteomes:UP000310129};
RA   Grana-Miraglia L., Castillo-Ramirez S., Cevallos M.A.;
RT   "Genome diversity A. baumannii Mexican isolates.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|EMBL:THJ60216.1, ECO:0000313|Proteomes:UP000280982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TG31307 {ECO:0000313|EMBL:THJ60216.1,
RC   ECO:0000313|Proteomes:UP000280982};
RA   Sahl J.;
RT   "Genome wide association studies (GWAS) and transcriptomics identifies
RT   cryptic antimicrobial resistance mechanisms in Acinetobacter baumannii.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|EMBL:TLT63582.1, ECO:0000313|Proteomes:UP000306363, ECO:0000313|Proteomes:UP000309525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aci00849 {ECO:0000313|EMBL:TLT67225.1,
RC   ECO:0000313|Proteomes:UP000309525}, and Aci00859
RC   {ECO:0000313|EMBL:TLT63582.1, ECO:0000313|Proteomes:UP000306363};
RA   Eigenbrod T., Reuter S., Gross A., Kocer K., Guenther F., Zimmermann S.,
RA   Heeg K., Mutters N.T., Nurjadi D.;
RT   "Molecular characterization of carbapenem-resistant Acinetobacter baumannii
RT   using whole-genome sequencing revealed missed transmission events, Germany,
RT   2012-2015.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|Proteomes:UP000315888, ECO:0000313|Proteomes:UP000318271, ECO:0000313|Proteomes:UP000318526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSN14237 {ECO:0000313|EMBL:TPU61657.1,
RC   ECO:0000313|Proteomes:UP000315888}, MRSN14427
RC   {ECO:0000313|EMBL:TPU81270.1, ECO:0000313|Proteomes:UP000320149},
RC   MRSN22112 {ECO:0000313|EMBL:TPU23229.1,
RC   ECO:0000313|Proteomes:UP000318586}, MRSN32875
RC   {ECO:0000313|EMBL:TPS97919.1, ECO:0000313|Proteomes:UP000318271},
RC   MRSN337038 {ECO:0000313|EMBL:TPS87062.1,
RC   ECO:0000313|Proteomes:UP000318526}, and MRSN7460
RC   {ECO:0000313|EMBL:TPS05618.1, ECO:0000313|Proteomes:UP000320596};
RA   Mcgann P., Snesrud E., Galac M.R.;
RT   "A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [34] {ECO:0000313|EMBL:QFH46123.1, ECO:0000313|Proteomes:UP000327158}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E47 {ECO:0000313|EMBL:QFH46123.1,
RC   ECO:0000313|Proteomes:UP000327158};
RA   Phan H.T.T., Stoesser N., Gordon K.A., Crook D., Walker S.A., Mathers A.J.,
RA   Peto T.E.A., George S., Lipworth S.I.;
RT   "Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged
RT   blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [35] {ECO:0000313|EMBL:QFV04791.1, ECO:0000313|Proteomes:UP000326007}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5457 {ECO:0000313|EMBL:QFV04791.1,
RC   ECO:0000313|Proteomes:UP000326007};
RA   Paul V., Sankar M.J., Gaind R., Ray P., Gautam V., Biswal M., Datta S.,
RA   Walia K., Kreiswirth B., Evans S., Fowler V., Patel R., Chambers H.C.,
RA   Bonomo R.A., Hujer K.M., Huker A., Adams M., Clarke T.H., Sutton G.,
RA   Nierman W.C., Nelson K.E., Fouts D.E.;
RT   "10 Multi-Drug Resistant Acinetobacter Baumannii Strains for ARLG-ICMR From
RT   India.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [36] {ECO:0000313|EMBL:QEY04997.1, ECO:0000313|Proteomes:UP000326895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAM180-1 {ECO:0000313|EMBL:QEY04997.1,
RC   ECO:0000313|Proteomes:UP000326895};
RA   Kim Y.-H., Kim B.K.;
RT   "Genome sequencing of Acinetobacter baumannii strain CAM180.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Removes the N-terminal methionine from nascent proteins. The
CC       N-terminal methionine is often cleaved when the second residue in the
CC       primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser,
CC       Thr, or Val). Requires deformylation of the N(alpha)-formylated
CC       initiator methionine before it can be hydrolyzed. {ECO:0000256|HAMAP-
CC       Rule:MF_01974}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal amino acids, preferentially methionine,
CC         from peptides and arylamides.; EC=3.4.11.18;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Note=Binds 2 divalent metal cations per subunit. Has a high-affinity
CC       and a low affinity metal-binding site. The true nature of the
CC       physiological cofactor is under debate. The enzyme is active with
CC       cobalt, zinc, manganese or divalent iron ions. Most likely, methionine
CC       aminopeptidases function as mononuclear Fe(2+)-metalloproteases under
CC       physiological conditions, and the catalytically relevant metal-binding
CC       site has been assigned to the histidine-containing high-affinity site.
CC       {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01974}.
CC   -!- SIMILARITY: Belongs to the peptidase M24A family. Methionine
CC       aminopeptidase type 1 subfamily. {ECO:0000256|HAMAP-Rule:MF_01974}.
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DR   EMBL; CP008706; AKA30982.1; -; Genomic_DNA.
DR   EMBL; CP026125; AUT38008.1; -; Genomic_DNA.
DR   EMBL; CP027178; AVI33300.1; -; Genomic_DNA.
DR   EMBL; LLGC01000179; KQE03489.1; -; Genomic_DNA.
DR   EMBL; LLGC01000126; KQE07355.1; -; Genomic_DNA.
DR   EMBL; LRDW01000036; KZA22651.1; -; Genomic_DNA.
DR   EMBL; LZVZ01000049; OBN25659.1; -; Genomic_DNA.
DR   EMBL; LDDY01000002; OBR20017.1; -; Genomic_DNA.
DR   EMBL; MDWM01000086; ODP71121.1; -; Genomic_DNA.
DR   EMBL; LYKI01000023; OIG72371.1; -; Genomic_DNA.
DR   EMBL; LYKQ01000028; OIH08354.1; -; Genomic_DNA.
DR   EMBL; NGEL01000129; OTM85450.1; -; Genomic_DNA.
DR   EMBL; NCYH01000005; OVL12321.1; -; Genomic_DNA.
DR   EMBL; NOXP01000002; OZT31344.1; -; Genomic_DNA.
DR   EMBL; NKKF01000020; PAM52585.1; -; Genomic_DNA.
DR   EMBL; NXDV01000014; PHQ01666.1; -; Genomic_DNA.
DR   EMBL; QKWF01000036; PZM18289.1; -; Genomic_DNA.
DR   EMBL; CP044356; QEY04997.1; -; Genomic_DNA.
DR   EMBL; CP042556; QFH46123.1; -; Genomic_DNA.
DR   EMBL; CP045541; QFV04791.1; -; Genomic_DNA.
DR   EMBL; RFBY01000023; RSP76616.1; -; Genomic_DNA.
DR   EMBL; RFCO01000002; RSQ49839.1; -; Genomic_DNA.
DR   EMBL; RFDJ01000009; RSR10093.1; -; Genomic_DNA.
DR   EMBL; RXYO01000031; RTY10994.1; -; Genomic_DNA.
DR   EMBL; SEUD01000002; RYL18680.1; -; Genomic_DNA.
DR   EMBL; SEUE01000002; RYL31564.1; -; Genomic_DNA.
DR   EMBL; SEUG01000001; RYL46242.1; -; Genomic_DNA.
DR   EMBL; UFMQ01000008; SST23566.1; -; Genomic_DNA.
DR   EMBL; UFNX01000008; SSU74255.1; -; Genomic_DNA.
DR   EMBL; UFSC01000003; SUU32078.1; -; Genomic_DNA.
DR   EMBL; UFRX01000001; SUU43619.1; -; Genomic_DNA.
DR   EMBL; SNVS01000103; TEX13795.1; -; Genomic_DNA.
DR   EMBL; SNVP01000116; TEX30240.1; -; Genomic_DNA.
DR   EMBL; SSBA01000072; TGY98765.1; -; Genomic_DNA.
DR   EMBL; SRZJ01000037; TGZ07088.1; -; Genomic_DNA.
DR   EMBL; RFBA02000001; THJ60216.1; -; Genomic_DNA.
DR   EMBL; VAGE01000010; TLT63582.1; -; Genomic_DNA.
DR   EMBL; VAFZ01000011; TLT67225.1; -; Genomic_DNA.
DR   EMBL; VHEA01000004; TPS05618.1; -; Genomic_DNA.
DR   EMBL; VHEY01000019; TPS87062.1; -; Genomic_DNA.
DR   EMBL; VHFD01000006; TPS97919.1; -; Genomic_DNA.
DR   EMBL; VHGJ01000009; TPU23229.1; -; Genomic_DNA.
DR   EMBL; VHGY01000042; TPU61657.1; -; Genomic_DNA.
DR   EMBL; VHGX01000005; TPU81270.1; -; Genomic_DNA.
DR   RefSeq; WP_001089491.1; NZ_WIVO01000004.1.
DR   PDB; 6MRF; X-ray; 1.65 A; A=12-272.
DR   PDBsum; 6MRF; -.
DR   STRING; 470.IX87_07995; -.
DR   EnsemblBacteria; AIL78573; AIL78573; IX87_07995.
DR   EnsemblBacteria; AKA30982; AKA30982; ABUW_1234.
DR   EnsemblBacteria; AKQ26271; AKQ26271; ACX60_05910.
DR   EnsemblBacteria; AMN02327; AMN02327; AZE33_14285.
DR   EnsemblBacteria; BAP65968; BAP65968; IOMTU433_1184.
DR   EnsemblBacteria; KMV05062; KMV05062; AB895_0353.
DR   EnsemblBacteria; KMV10717; KMV10717; AB988_0028.
DR   EnsemblBacteria; KQD20501; KQD20501; APD06_11055.
DR   EnsemblBacteria; KQK46469; KQK46469; AQ482_07905.
DR   EnsemblBacteria; KUI76164; KUI76164; AQ480_02225.
DR   EnsemblBacteria; KZA22651; KZA22651; LV38_03303.
DR   EnsemblBacteria; OBE59901; OBE59901; A7934_09120.
DR   EnsemblBacteria; ODP71121; ODP71121; BGC29_02575.
DR   GeneID; 31348596; -.
DR   KEGG; abaa:IX88_14615; -.
DR   KEGG; abau:IX87_07995; -.
DR   KEGG; abk:LX00_12565; -.
DR   KEGG; abw:BL01_08915; -.
DR   PATRIC; fig|470.1288.peg.1761; -.
DR   eggNOG; ENOG4105CA1; Bacteria.
DR   eggNOG; COG0024; LUCA.
DR   KO; K01265; -.
DR   OrthoDB; 1285136at2; -.
DR   Proteomes; UP000032746; Chromosome.
DR   Proteomes; UP000051449; Unassembled WGS sequence.
DR   Proteomes; UP000076314; Unassembled WGS sequence.
DR   Proteomes; UP000078586; Unassembled WGS sequence.
DR   Proteomes; UP000093852; Unassembled WGS sequence.
DR   Proteomes; UP000094982; Unassembled WGS sequence.
DR   Proteomes; UP000179791; Unassembled WGS sequence.
DR   Proteomes; UP000179937; Unassembled WGS sequence.
DR   Proteomes; UP000194699; Unassembled WGS sequence.
DR   Proteomes; UP000195460; Unassembled WGS sequence.
DR   Proteomes; UP000215800; Unassembled WGS sequence.
DR   Proteomes; UP000216874; Unassembled WGS sequence.
DR   Proteomes; UP000223291; Unassembled WGS sequence.
DR   Proteomes; UP000236385; Chromosome.
DR   Proteomes; UP000248662; Unassembled WGS sequence.
DR   Proteomes; UP000252694; Unassembled WGS sequence.
DR   Proteomes; UP000253591; Unassembled WGS sequence.
DR   Proteomes; UP000254993; Unassembled WGS sequence.
DR   Proteomes; UP000255154; Unassembled WGS sequence.
DR   Proteomes; UP000257523; Chromosome.
DR   Proteomes; UP000269597; Unassembled WGS sequence.
DR   Proteomes; UP000271711; Unassembled WGS sequence.
DR   Proteomes; UP000272401; Unassembled WGS sequence.
DR   Proteomes; UP000278858; Unassembled WGS sequence.
DR   Proteomes; UP000280982; Unassembled WGS sequence.
DR   Proteomes; UP000291489; Unassembled WGS sequence.
DR   Proteomes; UP000292081; Unassembled WGS sequence.
DR   Proteomes; UP000292122; Unassembled WGS sequence.
DR   Proteomes; UP000297480; Unassembled WGS sequence.
DR   Proteomes; UP000297782; Unassembled WGS sequence.
DR   Proteomes; UP000306363; Unassembled WGS sequence.
DR   Proteomes; UP000307835; Unassembled WGS sequence.
DR   Proteomes; UP000309525; Unassembled WGS sequence.
DR   Proteomes; UP000310129; Unassembled WGS sequence.
DR   Proteomes; UP000315888; Unassembled WGS sequence.
DR   Proteomes; UP000318271; Unassembled WGS sequence.
DR   Proteomes; UP000318526; Unassembled WGS sequence.
DR   Proteomes; UP000318586; Unassembled WGS sequence.
DR   Proteomes; UP000320149; Unassembled WGS sequence.
DR   Proteomes; UP000320596; Unassembled WGS sequence.
DR   Proteomes; UP000326007; Chromosome.
DR   Proteomes; UP000326895; Chromosome.
DR   Proteomes; UP000327158; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0070084; P:protein initiator methionine removal; IEA:UniProtKB-UniRule.
DR   CDD; cd01086; MetAP1; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   HAMAP; MF_01974; MetAP_1; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR001714; Pept_M24_MAP.
DR   InterPro; IPR002467; Pept_M24A_MAP1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   PRINTS; PR00599; MAPEPTIDASE.
DR   SUPFAM; SSF55920; SSF55920; 1.
DR   TIGRFAMs; TIGR00500; met_pdase_I; 1.
DR   PROSITE; PS00680; MAP_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:6MRF};
KW   Aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974,
KW   ECO:0000256|RuleBase:RU003653, ECO:0000313|EMBL:PZM18289.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000313|EMBL:PZM18289.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01974,
KW   ECO:0000256|RuleBase:RU003653};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653}.
FT   DOMAIN          19..256
FT                   /note="Peptidase_M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   METAL           110
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           121
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           121
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           185
FT                   /note="Divalent metal cation 2; catalytic; via tele
FT                   nitrogen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           218
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           249
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           249
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   BINDING         92
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   BINDING         192
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
SQ   SEQUENCE   275 AA;  30374 MW;  6D82AB2AE6DC1802 CRC64;
     MNSTYTAPRR LIKTPDEIEK MRIAGRLAAE VLDMIKPHIK AGVSTLELDT ICRNHIENVQ
     HAIPACVGYG GAPGRPAFQH SICTSVNHVV CHGIPSENKI LKNGDILNID VTVIKDGYHG
     DTNMMYIVGG ETSILANRLC KVAQEAMYRG MATVRDGSYL GDIGHAIQKY VESERFSVVR
     EYCGHGIGTV FHDEPQVLHY GQAGTGMRLE AGMTFTIEPM VNAGVWQTKL LGDKWTVVTK
     DHKLSAQYEH TILVTKTGIE VLTARPEEDL SRFNQ
//