ID   V5VCW7_ACIBA            Unreviewed;       275 AA.
AC   V5VCW7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   11-DEC-2019, entry version 65.
DE   RecName: Full=Methionine aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
DE            Short=MAP {ECO:0000256|HAMAP-Rule:MF_01974};
DE            Short=MetAP {ECO:0000256|HAMAP-Rule:MF_01974};
DE            EC=3.4.11.18 {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
DE   AltName: Full=Peptidase M {ECO:0000256|HAMAP-Rule:MF_01974};
GN   Name=map {ECO:0000256|HAMAP-Rule:MF_01974,
GN   ECO:0000313|EMBL:PZM18289.1};
GN   Synonyms=map1 {ECO:0000313|EMBL:AKA30982.1}, map_1
GN   {ECO:0000313|EMBL:KZA22651.1}, map_2 {ECO:0000313|EMBL:ASF78035.1};
GN   ORFNames=A7M79_08180 {ECO:0000313|EMBL:OIH08354.1}, A7M90_04815
GN   {ECO:0000313|EMBL:OIG72371.1}, ABUW_1234
GN   {ECO:0000313|EMBL:AKA30982.1}, B4R90_02870
GN   {ECO:0000313|EMBL:OVL12321.1}, B9X91_03550
GN   {ECO:0000313|EMBL:OTL50035.1}, B9X95_11705
GN   {ECO:0000313|EMBL:OTM85450.1}, BGC29_02575
GN   {ECO:0000313|EMBL:ODP71121.1}, C2U32_08280
GN   {ECO:0000313|EMBL:AUT38008.1}, CBE85_00465
GN   {ECO:0000313|EMBL:OWK68248.1}, CBI29_02666
GN   {ECO:0000313|EMBL:ASF78035.1}, CHQ89_03925
GN   {ECO:0000313|EMBL:OZT31344.1}, CPI82_15740
GN   {ECO:0000313|EMBL:PHQ01666.1}, CSB70_2491
GN   {ECO:0000313|EMBL:AVI33300.1}, D9Y30_01780
GN   {ECO:0000313|EMBL:TKV70091.1}, DCD77_06610
GN   {ECO:0000313|EMBL:PUV05937.1}, DOL94_04640
GN   {ECO:0000313|EMBL:PZM18289.1}, DWA21_06420
GN   {ECO:0000313|EMBL:TDI27933.1}, E2535_12730
GN   {ECO:0000313|EMBL:TEX21394.1}, E2536_05045
GN   {ECO:0000313|EMBL:TEX30240.1}, EA682_04370
GN   {ECO:0000313|EMBL:RSR22014.1}, EA685_09240
GN   {ECO:0000313|EMBL:RSR10093.1}, EA706_00955
GN   {ECO:0000313|EMBL:RSQ49839.1}, EA722_08630
GN   {ECO:0000313|EMBL:RSP76616.1}, EA746_001715
GN   {ECO:0000313|EMBL:THJ60216.1}, EJB02_02215
GN   {ECO:0000313|EMBL:RXD29034.1}, EKS29_06595
GN   {ECO:0000313|EMBL:RTY10994.1}, EWO92_05210
GN   {ECO:0000313|EMBL:RYL18680.1}, EWO96_05210
GN   {ECO:0000313|EMBL:RYL31564.1}, EWP49_05205
GN   {ECO:0000313|EMBL:RYL46242.1}, FJU36_01850
GN   {ECO:0000313|EMBL:TPU81270.1}, FJU76_01715
GN   {ECO:0000313|EMBL:TPS97919.1}, FJU79_05820
GN   {ECO:0000313|EMBL:TPS87062.1}, FJU87_03675
GN   {ECO:0000313|EMBL:TPU23229.1}, FJV14_00180
GN   {ECO:0000313|EMBL:TPS05618.1}, FJV27_04825
GN   {ECO:0000313|EMBL:TPU57575.1}, FQK04_05410
GN   {ECO:0000313|EMBL:TWO50388.1}, LV38_03303
GN   {ECO:0000313|EMBL:KZA22651.1}, NCTC13305_03581
GN   {ECO:0000313|EMBL:SUU32078.1}, SAMEA104305283_01206
GN   {ECO:0000313|EMBL:SSS24419.1}, SAMEA104305292_00658
GN   {ECO:0000313|EMBL:SSS43150.1}, SAMEA104305318_02021
GN   {ECO:0000313|EMBL:SST23566.1}, SAMEA104305351_02247
GN   {ECO:0000313|EMBL:SSU74255.1};
OS   Acinetobacter baumannii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter;
OC   Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470 {ECO:0000313|EMBL:PZM18289.1, ECO:0000313|Proteomes:UP000248662};
RN   [1] {ECO:0000313|EMBL:AKA30982.1, ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA30982.1,
RC   ECO:0000313|Proteomes:UP000032746};
RX   PubMed=25845845;
RA   Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., Held K.G.,
RA   Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.;
RT   "Resources for Genetic and Genomic Analysis of Emerging Pathogen
RT   Acinetobacter baumannii.";
RL   J. Bacteriol. 197:2027-2035(2015).
RN   [2] {ECO:0000313|Proteomes:UP000032746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746};
RA   Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., Radey M.R.,
RA   Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KZA22651.1, ECO:0000313|Proteomes:UP000076314}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB3638 {ECO:0000313|EMBL:KZA22651.1,
RC   ECO:0000313|Proteomes:UP000076314};
RA   Arivett B.A., Fiester S.E., Ream D.C., Actis L.A.;
RT   "Draft sequences of Acinetobacter baumannii isolates from wounded military
RT   personnel.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:OIG72371.1, ECO:0000313|Proteomes:UP000179791, ECO:0000313|Proteomes:UP000179937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XH639 {ECO:0000313|EMBL:OIH08354.1,
RC   ECO:0000313|Proteomes:UP000179791}, and XH647
RC   {ECO:0000313|EMBL:OIG72371.1, ECO:0000313|Proteomes:UP000179937};
RA   Hua X., Yu Y.;
RT   "The evolution of Acinetobacter baumannii in vivo.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ODP71121.1, ECO:0000313|Proteomes:UP000094982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XH198 {ECO:0000313|EMBL:ODP71121.1,
RC   ECO:0000313|Proteomes:UP000094982};
RA   Mu X., Wang N., Li X., Shi K., Zhou Z., Yu Y., Hua X.;
RT   "The effect of colistin resistance-associated mutations on the fitness of
RT   Acinetobacter baumannii.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:OVL12321.1, ECO:0000313|Proteomes:UP000195460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABUH557 {ECO:0000313|EMBL:OVL12321.1,
RC   ECO:0000313|Proteomes:UP000195460};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:OWK68248.1, ECO:0000313|Proteomes:UP000197394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB360 {ECO:0000313|EMBL:OWK68248.1,
RC   ECO:0000313|Proteomes:UP000197394};
RA   Wareham D.W., Bean D.C.;
RT   "Draft genome sequence of MDR A. baumannii AB360.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:OTL50035.1, ECO:0000313|Proteomes:UP000194699, ECO:0000313|Proteomes:UP000194957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR350 {ECO:0000313|EMBL:OTM85450.1,
RC   ECO:0000313|Proteomes:UP000194699}, and PR354
RC   {ECO:0000313|EMBL:OTL50035.1, ECO:0000313|Proteomes:UP000194957};
RA   Song R., Chenine A.L., Ruprecht R.M.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ASF78035.1, ECO:0000313|Proteomes:UP000197701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A85 {ECO:0000313|EMBL:ASF78035.1,
RC   ECO:0000313|Proteomes:UP000197701};
RA   Hamidian M., Wick R.R., Hawkey J., Holt K.E., Hall R.M.;
RT   "Complete genome sequence of Acinetobacter baumannii strain A85 belonging
RT   to global clone 1 (GC1).";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:OZT31344.1, ECO:0000313|Proteomes:UP000216874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DR1 {ECO:0000313|EMBL:OZT31344.1,
RC   ECO:0000313|Proteomes:UP000216874};
RA   Srinivasan V.B., Rajamohan G.;
RT   "Genome sequence, assembly and annotation.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:PHQ01666.1, ECO:0000313|Proteomes:UP000223291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=I43 {ECO:0000313|EMBL:PHQ01666.1,
RC   ECO:0000313|Proteomes:UP000223291};
RA   Siqueira K.A., Mello I.S., Mendes T.A., Soares M.A.;
RT   "Draft genome of Acinetobacter baumannii strain I43, a mercury resistant
RT   bacteria.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-17(2018).
RN   [13] {ECO:0000313|EMBL:AUT38008.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38008.1};
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:AUT38008.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38008.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:AVI33300.1, ECO:0000313|Proteomes:UP000257523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR_0070 {ECO:0000313|EMBL:AVI33300.1,
RC   ECO:0000313|Proteomes:UP000257523};
RA   Benahmed F.H., Lutgring J.D., Yoo B., Machado M., Brown A., McAllister G.,
RA   Perry A., Halpin A.L., Vavikolanu K., Ott S., Zhao X., Tallon L.,
RA   Sadzewicz L., Aluvathingal J., Nadendla S., Voskania-kordi A., Simonyan V.,
RA   Patel J., Shawar R.M.;
RT   "FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:PUV05937.1, ECO:0000313|Proteomes:UP000251219}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH37 {ECO:0000313|EMBL:PUV05937.1,
RC   ECO:0000313|Proteomes:UP000251219};
RA   Yang Y., Yu Y.;
RT   "Sulbactam resistance mechanism of Acinetobacter baumannii.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:PZM18289.1, ECO:0000313|Proteomes:UP000248662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R10 {ECO:0000313|EMBL:PZM18289.1,
RC   ECO:0000313|Proteomes:UP000248662};
RA   Bonnin R.A., Levy M., Cuzon G., Dortet L., Naas T.;
RT   "Carbapenemase-producing Acinetobacter spp. from environmental sources in
RT   an hospital from French Polynesia.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:SUU32078.1, ECO:0000313|Proteomes:UP000255154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13305 {ECO:0000313|EMBL:SUU32078.1,
RC   ECO:0000313|Proteomes:UP000255154};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|Proteomes:UP000252694, ECO:0000313|Proteomes:UP000253591, ECO:0000313|Proteomes:UP000262639}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY7045788 {ECO:0000313|EMBL:SSS24419.1,
RC   ECO:0000313|Proteomes:UP000264160}, 4300STDY7045797
RC   {ECO:0000313|EMBL:SSS43150.1, ECO:0000313|Proteomes:UP000262639},
RC   4300STDY7045823 {ECO:0000313|EMBL:SST23566.1,
RC   ECO:0000313|Proteomes:UP000252694}, and 4300STDY7045856
RC   {ECO:0000313|EMBL:SSU74255.1, ECO:0000313|Proteomes:UP000253591};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|EMBL:TKV70091.1, ECO:0000313|Proteomes:UP000306786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LWSS- 03-02-11A {ECO:0000313|EMBL:TKV70091.1,
RC   ECO:0000313|Proteomes:UP000306786};
RA   Hammerl J.A., Savin M., Parcina M., Kreyenschmidt J.;
RT   "Complete genome sequence of Acinetobacter baumannii isolates.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000213|PDB:6MRF}
RP   X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 12-272.
RA   Edwards T.E., Mayclin S.J., Lorimer D.D., Horanyi P.S.,
RA   Seattle Structural Genomics Center for Infectious Disease.;
RT   "Crystal structure of a Methionine aminopeptidase MetAP from Acinetobacter
RT   baumannii.";
RL   Submitted (OCT-2018) to the PDB data bank.
RN   [23] {ECO:0000313|Proteomes:UP000269597, ECO:0000313|Proteomes:UP000271711, ECO:0000313|Proteomes:UP000272401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TG22168 {ECO:0000313|EMBL:RSQ49839.1,
RC   ECO:0000313|Proteomes:UP000272401}, TG31299
RC   {ECO:0000313|EMBL:RSP76616.1, ECO:0000313|Proteomes:UP000269597},
RC   TG31307 {ECO:0000313|Proteomes:UP000280982}, TG41016
RC   {ECO:0000313|EMBL:RSR10093.1, ECO:0000313|Proteomes:UP000271711}, and
RC   TG89524 {ECO:0000313|EMBL:RSR22014.1,
RC   ECO:0000313|Proteomes:UP000273400};
RA   Sahl J.W.;
RT   "GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance
RT   in Acinetobacter baumannii.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:THJ60216.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TG31307 {ECO:0000313|EMBL:THJ60216.1};
RA   Sahl J.W.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:RTY10994.1, ECO:0000313|Proteomes:UP000278858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AM107 {ECO:0000313|EMBL:RTY10994.1,
RC   ECO:0000313|Proteomes:UP000278858};
RA   Fouts D.E., Sutton G., Singh I., Nguyen K.;
RT   "Na.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:RXD29034.1, ECO:0000313|Proteomes:UP000289798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT722 {ECO:0000313|EMBL:RXD29034.1,
RC   ECO:0000313|Proteomes:UP000289798};
RA   Hazan R.;
RT   "Successful treatment of antibiotic resistant poly-microbial bone infection
RT   with bacteriophages.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|Proteomes:UP000291489, ECO:0000313|Proteomes:UP000292081, ECO:0000313|Proteomes:UP000292122}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C1T1-1 {ECO:0000313|EMBL:RYL46242.1,
RC   ECO:0000313|Proteomes:UP000291489}, C1T1-2_b
RC   {ECO:0000313|EMBL:RYL31564.1, ECO:0000313|Proteomes:UP000292081}, and
RC   C1T1-3 {ECO:0000313|EMBL:RYL18680.1,
RC   ECO:0000313|Proteomes:UP000292122};
RA   Rehman M.A.;
RT   "Whole-Genome Sequences of Acinetobacter spp Isolated From Dairy Cow
RT   Manure.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:TDI27933.1, ECO:0000313|Proteomes:UP000295086}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pesh-26 {ECO:0000313|EMBL:TDI27933.1,
RC   ECO:0000313|Proteomes:UP000295086};
RA   Karah N., Khalid F., Wai S.N., Ahmed I., Uhlin B.E.;
RT   "Molecular epidemiology and antibiotic resistance features of Acinetobacter
RT   baumannii clinical isolates from Pakistan.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|EMBL:TEX21394.1, ECO:0000313|Proteomes:UP000297480, ECO:0000313|Proteomes:UP000298079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MDR-CQD {ECO:0000313|EMBL:TEX21394.1,
RC   ECO:0000313|Proteomes:UP000298079}, and MDR-CQE
RC   {ECO:0000313|EMBL:TEX30240.1, ECO:0000313|Proteomes:UP000297480};
RA   Jian Z.;
RT   "Resequencing Analysis and Multi-drug Resistance Differences of
RT   Acinetobacter baumannii in Chongqing, China.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:THJ60216.1, ECO:0000313|Proteomes:UP000280982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TG31307 {ECO:0000313|EMBL:THJ60216.1,
RC   ECO:0000313|Proteomes:UP000280982};
RA   Sahl J.;
RT   "Genome wide association studies (GWAS) and transcriptomics identifies
RT   cryptic antimicrobial resistance mechanisms in Acinetobacter baumannii.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|Proteomes:UP000318271, ECO:0000313|Proteomes:UP000318462, ECO:0000313|Proteomes:UP000318526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSN14427 {ECO:0000313|EMBL:TPU81270.1,
RC   ECO:0000313|Proteomes:UP000320149}, MRSN15070
RC   {ECO:0000313|EMBL:TPU57575.1, ECO:0000313|Proteomes:UP000318462},
RC   MRSN22112 {ECO:0000313|EMBL:TPU23229.1,
RC   ECO:0000313|Proteomes:UP000318586}, MRSN32875
RC   {ECO:0000313|EMBL:TPS97919.1, ECO:0000313|Proteomes:UP000318271},
RC   MRSN337038 {ECO:0000313|EMBL:TPS87062.1,
RC   ECO:0000313|Proteomes:UP000318526}, and MRSN7460
RC   {ECO:0000313|EMBL:TPS05618.1, ECO:0000313|Proteomes:UP000320596};
RA   Mcgann P., Snesrud E., Galac M.R.;
RT   "A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|EMBL:TWO50388.1, ECO:0000313|Proteomes:UP000320356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A42 {ECO:0000313|EMBL:TWO50388.1,
RC   ECO:0000313|Proteomes:UP000320356};
RA   Ruan Z., Jia H.;
RT   "Draft genome sequence of Acinetobacter baumannii A42.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Removes the N-terminal methionine from nascent proteins. The
CC       N-terminal methionine is often cleaved when the second residue in the
CC       primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser,
CC       Thr, or Val). Requires deformylation of the N(alpha)-formylated
CC       initiator methionine before it can be hydrolyzed. {ECO:0000256|HAMAP-
CC       Rule:MF_01974}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal amino acids, preferentially methionine,
CC         from peptides and arylamides.; EC=3.4.11.18;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01974,
CC         ECO:0000256|RuleBase:RU003653};
CC       Note=Binds 2 divalent metal cations per subunit. Has a high-affinity
CC       and a low affinity metal-binding site. The true nature of the
CC       physiological cofactor is under debate. The enzyme is active with
CC       cobalt, zinc, manganese or divalent iron ions. Most likely, methionine
CC       aminopeptidases function as mononuclear Fe(2+)-metalloproteases under
CC       physiological conditions, and the catalytically relevant metal-binding
CC       site has been assigned to the histidine-containing high-affinity site.
CC       {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01974}.
CC   -!- SIMILARITY: Belongs to the peptidase M24A family. Methionine
CC       aminopeptidase type 1 subfamily. {ECO:0000256|HAMAP-Rule:MF_01974}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP008706; AKA30982.1; -; Genomic_DNA.
DR   EMBL; CP021782; ASF78035.1; -; Genomic_DNA.
DR   EMBL; CP026125; AUT38008.1; -; Genomic_DNA.
DR   EMBL; CP027178; AVI33300.1; -; Genomic_DNA.
DR   EMBL; LRDW01000036; KZA22651.1; -; Genomic_DNA.
DR   EMBL; MDWM01000086; ODP71121.1; -; Genomic_DNA.
DR   EMBL; LYKI01000023; OIG72371.1; -; Genomic_DNA.
DR   EMBL; LYKQ01000028; OIH08354.1; -; Genomic_DNA.
DR   EMBL; NGCH01000216; OTL50035.1; -; Genomic_DNA.
DR   EMBL; NGEL01000129; OTM85450.1; -; Genomic_DNA.
DR   EMBL; NCYH01000005; OVL12321.1; -; Genomic_DNA.
DR   EMBL; NGKM01000001; OWK68248.1; -; Genomic_DNA.
DR   EMBL; NOXP01000002; OZT31344.1; -; Genomic_DNA.
DR   EMBL; NXDV01000014; PHQ01666.1; -; Genomic_DNA.
DR   EMBL; QCXV01000006; PUV05937.1; -; Genomic_DNA.
DR   EMBL; QKWF01000036; PZM18289.1; -; Genomic_DNA.
DR   EMBL; RFBY01000023; RSP76616.1; -; Genomic_DNA.
DR   EMBL; RFCO01000002; RSQ49839.1; -; Genomic_DNA.
DR   EMBL; RFDJ01000009; RSR10093.1; -; Genomic_DNA.
DR   EMBL; RFDM01000003; RSR22014.1; -; Genomic_DNA.
DR   EMBL; RXYO01000031; RTY10994.1; -; Genomic_DNA.
DR   EMBL; RXIN01000005; RXD29034.1; -; Genomic_DNA.
DR   EMBL; SEUD01000002; RYL18680.1; -; Genomic_DNA.
DR   EMBL; SEUE01000002; RYL31564.1; -; Genomic_DNA.
DR   EMBL; SEUG01000001; RYL46242.1; -; Genomic_DNA.
DR   EMBL; UFLV01000015; SSS24419.1; -; Genomic_DNA.
DR   EMBL; UFLY01000003; SSS43150.1; -; Genomic_DNA.
DR   EMBL; UFMQ01000008; SST23566.1; -; Genomic_DNA.
DR   EMBL; UFNX01000008; SSU74255.1; -; Genomic_DNA.
DR   EMBL; UFSC01000003; SUU32078.1; -; Genomic_DNA.
DR   EMBL; SMUH01000085; TDI27933.1; -; Genomic_DNA.
DR   EMBL; SNVQ01000090; TEX21394.1; -; Genomic_DNA.
DR   EMBL; SNVP01000116; TEX30240.1; -; Genomic_DNA.
DR   EMBL; RFBA02000001; THJ60216.1; -; Genomic_DNA.
DR   EMBL; RCUZ01000001; TKV70091.1; -; Genomic_DNA.
DR   EMBL; VHEA01000004; TPS05618.1; -; Genomic_DNA.
DR   EMBL; VHEY01000019; TPS87062.1; -; Genomic_DNA.
DR   EMBL; VHFD01000006; TPS97919.1; -; Genomic_DNA.
DR   EMBL; VHGJ01000009; TPU23229.1; -; Genomic_DNA.
DR   EMBL; VHGV01000009; TPU57575.1; -; Genomic_DNA.
DR   EMBL; VHGX01000005; TPU81270.1; -; Genomic_DNA.
DR   EMBL; VNWR01000013; TWO50388.1; -; Genomic_DNA.
DR   RefSeq; WP_001089491.1; NZ_VTBA01000019.1.
DR   PDB; 6MRF; X-ray; 1.65 A; A=12-272.
DR   PDBsum; 6MRF; -.
DR   STRING; 470.IX87_07995; -.
DR   EnsemblBacteria; AIL78573; AIL78573; IX87_07995.
DR   EnsemblBacteria; AKA30982; AKA30982; ABUW_1234.
DR   EnsemblBacteria; AKQ26271; AKQ26271; ACX60_05910.
DR   EnsemblBacteria; AMN02327; AMN02327; AZE33_14285.
DR   EnsemblBacteria; BAP65968; BAP65968; IOMTU433_1184.
DR   EnsemblBacteria; KMV05062; KMV05062; AB895_0353.
DR   EnsemblBacteria; KMV10717; KMV10717; AB988_0028.
DR   EnsemblBacteria; KQD20501; KQD20501; APD06_11055.
DR   EnsemblBacteria; KQK46469; KQK46469; AQ482_07905.
DR   EnsemblBacteria; KUI76164; KUI76164; AQ480_02225.
DR   EnsemblBacteria; KZA22651; KZA22651; LV38_03303.
DR   EnsemblBacteria; OBE59901; OBE59901; A7934_09120.
DR   EnsemblBacteria; ODP71121; ODP71121; BGC29_02575.
DR   GeneID; 31348596; -.
DR   KEGG; abaa:IX88_14615; -.
DR   KEGG; abau:IX87_07995; -.
DR   KEGG; abk:LX00_12565; -.
DR   KEGG; abw:BL01_08915; -.
DR   PATRIC; fig|470.1288.peg.1761; -.
DR   eggNOG; ENOG4105CA1; Bacteria.
DR   eggNOG; COG0024; LUCA.
DR   KO; K01265; -.
DR   OrthoDB; 1285136at2; -.
DR   Proteomes; UP000032746; Chromosome.
DR   Proteomes; UP000076314; Unassembled WGS sequence.
DR   Proteomes; UP000094982; Unassembled WGS sequence.
DR   Proteomes; UP000179791; Unassembled WGS sequence.
DR   Proteomes; UP000179937; Unassembled WGS sequence.
DR   Proteomes; UP000194699; Unassembled WGS sequence.
DR   Proteomes; UP000194957; Unassembled WGS sequence.
DR   Proteomes; UP000195460; Unassembled WGS sequence.
DR   Proteomes; UP000197394; Unassembled WGS sequence.
DR   Proteomes; UP000197701; Chromosome.
DR   Proteomes; UP000216874; Unassembled WGS sequence.
DR   Proteomes; UP000223291; Unassembled WGS sequence.
DR   Proteomes; UP000236385; Chromosome.
DR   Proteomes; UP000248662; Unassembled WGS sequence.
DR   Proteomes; UP000251219; Unassembled WGS sequence.
DR   Proteomes; UP000252694; Unassembled WGS sequence.
DR   Proteomes; UP000253591; Unassembled WGS sequence.
DR   Proteomes; UP000255154; Unassembled WGS sequence.
DR   Proteomes; UP000257523; Chromosome.
DR   Proteomes; UP000262639; Unassembled WGS sequence.
DR   Proteomes; UP000264160; Unassembled WGS sequence.
DR   Proteomes; UP000269597; Unassembled WGS sequence.
DR   Proteomes; UP000271711; Unassembled WGS sequence.
DR   Proteomes; UP000272401; Unassembled WGS sequence.
DR   Proteomes; UP000273400; Unassembled WGS sequence.
DR   Proteomes; UP000278858; Unassembled WGS sequence.
DR   Proteomes; UP000280982; Unassembled WGS sequence.
DR   Proteomes; UP000289798; Unassembled WGS sequence.
DR   Proteomes; UP000291489; Unassembled WGS sequence.
DR   Proteomes; UP000292081; Unassembled WGS sequence.
DR   Proteomes; UP000292122; Unassembled WGS sequence.
DR   Proteomes; UP000295086; Unassembled WGS sequence.
DR   Proteomes; UP000297480; Unassembled WGS sequence.
DR   Proteomes; UP000298079; Unassembled WGS sequence.
DR   Proteomes; UP000306786; Unassembled WGS sequence.
DR   Proteomes; UP000318271; Unassembled WGS sequence.
DR   Proteomes; UP000318462; Unassembled WGS sequence.
DR   Proteomes; UP000318526; Unassembled WGS sequence.
DR   Proteomes; UP000318586; Unassembled WGS sequence.
DR   Proteomes; UP000320149; Unassembled WGS sequence.
DR   Proteomes; UP000320356; Unassembled WGS sequence.
DR   Proteomes; UP000320596; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0070084; P:protein initiator methionine removal; IEA:UniProtKB-UniRule.
DR   CDD; cd01086; MetAP1; 1.
DR   Gene3D; 3.90.230.10; -; 1.
DR   HAMAP; MF_01974; MetAP_1; 1.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR001714; Pept_M24_MAP.
DR   InterPro; IPR002467; Pept_M24A_MAP1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   PRINTS; PR00599; MAPEPTIDASE.
DR   SUPFAM; SSF55920; SSF55920; 1.
DR   TIGRFAMs; TIGR00500; met_pdase_I; 1.
DR   PROSITE; PS00680; MAP_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:6MRF};
KW   Aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974,
KW   ECO:0000256|RuleBase:RU003653, ECO:0000313|EMBL:PZM18289.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000313|EMBL:PZM18289.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01974,
KW   ECO:0000256|RuleBase:RU003653};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032746}.
FT   DOMAIN          19..256
FT                   /note="Peptidase_M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   METAL           110
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           121
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           121
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           185
FT                   /note="Divalent metal cation 2; catalytic; via tele
FT                   nitrogen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           218
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           249
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   METAL           249
FT                   /note="Divalent metal cation 2; catalytic"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   BINDING         92
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
FT   BINDING         192
FT                   /note="Substrate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01974"
SQ   SEQUENCE   275 AA;  30374 MW;  6D82AB2AE6DC1802 CRC64;
     MNSTYTAPRR LIKTPDEIEK MRIAGRLAAE VLDMIKPHIK AGVSTLELDT ICRNHIENVQ
     HAIPACVGYG GAPGRPAFQH SICTSVNHVV CHGIPSENKI LKNGDILNID VTVIKDGYHG
     DTNMMYIVGG ETSILANRLC KVAQEAMYRG MATVRDGSYL GDIGHAIQKY VESERFSVVR
     EYCGHGIGTV FHDEPQVLHY GQAGTGMRLE AGMTFTIEPM VNAGVWQTKL LGDKWTVVTK
     DHKLSAQYEH TILVTKTGIE VLTARPEEDL SRFNQ
//