ID V5VCW7_ACIBA Unreviewed; 275 AA. AC V5VCW7; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 31-JAN-2018, entry version 44. DE RecName: Full=Methionine aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; DE Short=MAP {ECO:0000256|HAMAP-Rule:MF_01974}; DE Short=MetAP {ECO:0000256|HAMAP-Rule:MF_01974}; DE EC=3.4.11.18 {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; DE AltName: Full=Peptidase M {ECO:0000256|HAMAP-Rule:MF_01974}; GN Name=map {ECO:0000256|HAMAP-Rule:MF_01974, GN ECO:0000313|EMBL:ATR87285.1}; GN Synonyms=map1 {ECO:0000313|EMBL:AKA30982.1}, map_1 GN {ECO:0000313|EMBL:ATP86485.1}, map_2 {ECO:0000313|EMBL:ASF78035.1}; GN ORFNames=A388_01269 {ECO:0000313|EMBL:ATP86485.1}, A7A65_11205 GN {ECO:0000313|EMBL:OWW98854.1}, A7M79_08180 GN {ECO:0000313|EMBL:OIH08354.1}, A7M90_04815 GN {ECO:0000313|EMBL:OIG72371.1}, A7N09_12540 GN {ECO:0000313|EMBL:OIF74617.1}, AB895_0353 GN {ECO:0000313|EMBL:KMV05062.1}, ABUW_1234 GN {ECO:0000313|EMBL:AKA30982.1}, APD06_11055 GN {ECO:0000313|EMBL:KQD20501.1}, AYP_002589 GN {ECO:0000313|EMBL:ATU23859.1}, AZE33_14285 GN {ECO:0000313|EMBL:AMN02327.1}, B4N82_07035 GN {ECO:0000313|EMBL:PIL50289.1}, B4N86_12405 GN {ECO:0000313|EMBL:PIL59175.1}, B4N87_07890 GN {ECO:0000313|EMBL:PIL57427.1}, B4N88_11770 GN {ECO:0000313|EMBL:PIL55402.1}, B4N90_12785 GN {ECO:0000313|EMBL:PIL67103.1}, B4O93_11235 GN {ECO:0000313|EMBL:PIL65147.1}, B4O95_00585 GN {ECO:0000313|EMBL:PIL76819.1}, B4Q07_11375 GN {ECO:0000313|EMBL:PIL77371.1}, B4Q08_07035 GN {ECO:0000313|EMBL:PIL82665.1}, B4Q10_07995 GN {ECO:0000313|EMBL:PIL88249.1}, B4R90_02870 GN {ECO:0000313|EMBL:OVL12321.1}, B9X91_03550 GN {ECO:0000313|EMBL:OTL50035.1}, B9X95_11705 GN {ECO:0000313|EMBL:OTM85450.1}, BGC29_02575 GN {ECO:0000313|EMBL:ODP71121.1}, BWP00_06705 GN {ECO:0000313|EMBL:OOD23107.1}, CBE85_00465 GN {ECO:0000313|EMBL:OWK68248.1}, CBI29_02666 GN {ECO:0000313|EMBL:ASF78035.1}, CEJ63_06330 GN {ECO:0000313|EMBL:PAM74467.1}, CHH37_17750 GN {ECO:0000313|EMBL:PHM87017.1}, CHH39_17995 GN {ECO:0000313|EMBL:PHM79701.1}, CHQ89_03925 GN {ECO:0000313|EMBL:OZT31344.1}, CKN52_10930 GN {ECO:0000313|EMBL:PHP82810.1}, CPI82_15740 GN {ECO:0000313|EMBL:PHQ01666.1}, CTI08_08265 GN {ECO:0000313|EMBL:ATR87285.1}, CTZ18_05545 GN {ECO:0000313|EMBL:ATU52040.1}, CTZ19_06095 GN {ECO:0000313|EMBL:ATU55759.1}, CTZ20_05855 GN {ECO:0000313|EMBL:ATU48426.1}, CUC59_10215 GN {ECO:0000313|EMBL:PIN45170.1}, CUC60_08365 GN {ECO:0000313|EMBL:PIN37871.1}, CUC61_07475 GN {ECO:0000313|EMBL:PIN49471.1}, CUC62_08145 GN {ECO:0000313|EMBL:PIN41728.1}, IX87_07995 GN {ECO:0000313|EMBL:AIL78573.1}, LV38_03303 GN {ECO:0000313|EMBL:KZA22651.1}; OS Acinetobacter baumannii. OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; OC Moraxellaceae; Acinetobacter; OC Acinetobacter calcoaceticus/baumannii complex. OX NCBI_TaxID=470 {ECO:0000313|EMBL:KQD20501.1, ECO:0000313|Proteomes:UP000051322}; RN [1] {ECO:0000313|EMBL:AIL78573.1, ECO:0000313|Proteomes:UP000028932} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB030 {ECO:0000313|EMBL:AIL78573.1}, and AB30 RC {ECO:0000313|Proteomes:UP000028932}; RA Loewen P.C., Kumar A.; RT "Genome sequence of Acinetobacter baumannii AB030 genome."; RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AKA30982.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB5075-UW {ECO:0000313|EMBL:AKA30982.1}; RX PubMed=25845845; RA Gallagher L.A., Ramage E., Weiss E.J., Radey M., Hayden H.S., RA Held K.G., Huse H.K., Zurawski D.V., Brittnacher M.J., Manoil C.; RT "Resources for Genetic and Genomic Analysis of Emerging Pathogen RT Acinetobacter baumannii."; RL J. Bacteriol. 197:2027-2035(2015). RN [3] {ECO:0000313|Proteomes:UP000032746} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB5075-UW {ECO:0000313|Proteomes:UP000032746}; RA Gallagher L.A., Hayden H.S., Weiss E.J., Hager K.R., Ramage E., RA Radey M.R., Bydalek R., Manoil C., Miller S.I., Brittnacher M.J.; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CQR89265.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CHI-32 {ECO:0000313|EMBL:CQR89265.1}; RA Jones S Lim; RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:KMV05062.1, ECO:0000313|Proteomes:UP000036720} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B8342 {ECO:0000313|EMBL:KMV05062.1, RC ECO:0000313|Proteomes:UP000036720}; RA Vijaykumar S., Balaji V., Biswas I.; RT "Complete genome sequence of Acinetobacter baumannii strain B8342, a RT motility positive clinical isolate."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:KQD20501.1, ECO:0000313|Proteomes:UP000051322} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ABBL059 {ECO:0000313|EMBL:KQD20501.1, RC ECO:0000313|Proteomes:UP000051322}; RA Ozer E.A., Fitzpatrick M.A., Hauser A.R.; RT "The utility of whole genome sequencing in characterizing RT Acinetobacter epidemiology and analyzing hospital outbreaks."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:KZA22651.1, ECO:0000313|Proteomes:UP000076314} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB3638 {ECO:0000313|EMBL:KZA22651.1, RC ECO:0000313|Proteomes:UP000076314}; RA Arivett B.A., Fiester S.E., Ream D.C., Actis L.A.; RT "Draft sequences of Acinetobacter baumannii isolates from wounded RT military personnel."; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AMN02327.1, ECO:0000313|Proteomes:UP000070590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=XH858 {ECO:0000313|EMBL:AMN02327.1, RC ECO:0000313|Proteomes:UP000070590}; RA Feng Y., Hua X., Yu Y.; RT "Complete genome of Acinetobacter baumannii str. XH858."; RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|Proteomes:UP000179770, ECO:0000313|Proteomes:UP000179791, ECO:0000313|Proteomes:UP000179937} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=XH639 {ECO:0000313|EMBL:OIH08354.1, RC ECO:0000313|Proteomes:UP000179791}, XH647 RC {ECO:0000313|EMBL:OIG72371.1, ECO:0000313|Proteomes:UP000179937}, and RC XH694 {ECO:0000313|EMBL:OIF74617.1, RC ECO:0000313|Proteomes:UP000179770}; RA Hua X., Yu Y.; RT "The evolution of Acinetobacter baumannii in vivo."; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:OWW98854.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB314 {ECO:0000313|EMBL:OWW98854.1}; RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:ODP71121.1, ECO:0000313|Proteomes:UP000094982} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=XH198 {ECO:0000313|EMBL:ODP71121.1, RC ECO:0000313|Proteomes:UP000094982}; RA Mu X., Wang N., Li X., Shi K., Zhou Z., Yu Y., Hua X.; RT "The effect of colistin resistance-associated mutations on the fitness RT of Acinetobacter baumannii."; RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:OOD23107.1, ECO:0000313|Proteomes:UP000188718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 17945 {ECO:0000313|EMBL:OOD23107.1, RC ECO:0000313|Proteomes:UP000188718}; RA Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R., RA Crandall J., Chaturvedi V.; RT "Validation and Implementation of CLIA-Compliant Whole Genome RT Sequencing (WGS) in Public Health Laboratory."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:PIL50289.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M1 {ECO:0000313|EMBL:PIL50289.1}; RA Jaidane N., Bonnin R., Mansour W., Weslati S., Kalboussi N., RA Boujaafar N., Bouallegue O., Naas T.; RT "Dissemination and characterization of NDM-producing Acinetobacter RT baumannii in a teaching hospital in Tunisia."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:PIL67103.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M5 {ECO:0000313|EMBL:PIL67103.1}; RA Jaidane N., Bonnin R., Mansour W., Weslati S., Boujaafar N., RA Bouallegue O., Naas T.; RT "Dissemination of NDM-producing Acinetobacter baumannii in a teaching RT hospital in Tunisia."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:PIL55402.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M3 {ECO:0000313|EMBL:PIL57427.1}, and MBL_M4 RC {ECO:0000313|EMBL:PIL55402.1}; RA Jaidane N., Bonnin R., Mansour W., Weslati S., Kalboussi N., RA Boujaafar N., Bouallegue O., Naas T.; RT "Dissemination of ST-85 harboring NDM-producing Acinetobacter RT baumannii in a teaching hospital in Tunisia."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:PIL59175.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M2 {ECO:0000313|EMBL:PIL59175.1}; RA Peterson S.W.; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:PIL65147.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M11 {ECO:0000313|EMBL:PIL88249.1}, MBL_M6 RC {ECO:0000313|EMBL:PIL65147.1}, MBL_M7 {ECO:0000313|EMBL:PIL76819.1}, RC and MBL_M9 {ECO:0000313|EMBL:PIL77371.1}; RA Jaidane N., Bonnin R., Mansour W., Weslati S., Kalboussi N., RA Boujaafar N., Bouallegue O., Naas T.; RT "Dissemination of NDM-producing Acinetobacter baumannii in a teaching RT hospital in Tunisia."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:PIL82665.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M10 {ECO:0000313|EMBL:PIL82665.1}; RA Jaidane N., Bonnin R., Mansour W., Weslati S., Kalboussi N., RA Boujaafar N., Bouallegue O., Naas T.; RT "This is the first description of blaNDM positive A. baumannii strains RT recovered from autochthonous cases in a teaching hospital in RT Tunisia."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:OVL12321.1, ECO:0000313|Proteomes:UP000195460} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ABUH557 {ECO:0000313|EMBL:OVL12321.1, RC ECO:0000313|Proteomes:UP000195460}; RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I., RA Dimitrov K.M., Suarez D.L., Swayne D.E.; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:OWK68248.1, ECO:0000313|Proteomes:UP000197394} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB360 {ECO:0000313|EMBL:OWK68248.1, RC ECO:0000313|Proteomes:UP000197394}; RA Wareham D.W., Bean D.C.; RT "Draft genome sequence of MDR A. baumannii AB360."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:OTL50035.1, ECO:0000313|Proteomes:UP000194699, ECO:0000313|Proteomes:UP000194957} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PR350 {ECO:0000313|EMBL:OTM85450.1, RC ECO:0000313|Proteomes:UP000194699}, and PR354 RC {ECO:0000313|EMBL:OTL50035.1, ECO:0000313|Proteomes:UP000194957}; RA Song R., Chenine A.L., Ruprecht R.M.; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:PAM74467.1, ECO:0000313|Proteomes:UP000216072} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB75 {ECO:0000313|EMBL:PAM74467.1, RC ECO:0000313|Proteomes:UP000216072}; RA Chen Q.; RT "Carbapenem-resistant Acinetobacter baumannii strains."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [23] {ECO:0000313|EMBL:ASF78035.1, ECO:0000313|Proteomes:UP000197701} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A85 {ECO:0000313|EMBL:ASF78035.1, RC ECO:0000313|Proteomes:UP000197701}; RA Hamidian M., Wick R.R., Hawkey J., Holt K.E., Hall R.M.; RT "Complete genome sequence of Acinetobacter baumannii strain A85 RT belonging to global clone 1 (GC1)."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [24] {ECO:0000313|EMBL:PHM79701.1, ECO:0000313|Proteomes:UP000221207, ECO:0000313|Proteomes:UP000225909} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ABA1614 {ECO:0000313|EMBL:PHM87017.1, RC ECO:0000313|Proteomes:UP000221207}, and ABA2114 RC {ECO:0000313|EMBL:PHM79701.1, ECO:0000313|Proteomes:UP000225909}; RA Gba K.M.K., Guessennd N.K., Bonnin R.A., Naas T., N'Guetta S.-P.A., RA Dosso M.; RT "First detection of NDM-1-producing Acinetobacter baumannii and RT Acinetobacter nosocomialis in Ivory Coast."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [25] {ECO:0000313|EMBL:OZT31344.1, ECO:0000313|Proteomes:UP000216874} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DR1 {ECO:0000313|EMBL:OZT31344.1, RC ECO:0000313|Proteomes:UP000216874}; RA Srinivasan V.B., Rajamohan G.; RT "Genome sequence, assembly and annotation."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [26] {ECO:0000313|EMBL:PHQ01666.1, ECO:0000313|Proteomes:UP000223291} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=I43 {ECO:0000313|EMBL:PHQ01666.1, RC ECO:0000313|Proteomes:UP000223291}; RA Siqueira K.A., Mello I.S., Mendes T.A., Soares M.A.; RT "Draft genome of Acinetobacter baumannii strain I43, a mercury RT resistant bacteria."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:PHP82810.1, ECO:0000313|Proteomes:UP000223836} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Abau471 {ECO:0000313|EMBL:PHP82810.1, RC ECO:0000313|Proteomes:UP000223836}; RA Dossim S., Salou M., Bonnin R., Tanga K., Godonou V., Prince David M., RA Naas T., Dagnra A.Y.; RT "First Detection of Carbapenemases genes in Acinetobacter baumannii RT strains in Lome (Togo)."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:ATP86485.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A388 {ECO:0000313|EMBL:ATP86485.1}; RA Hamidian M., Wick R., Judd L., Holt K.E., Hall R.M.; RT "Complete genome sequence of Acinetobacter baumannii strain A388 RT belonging to global clone 1 recovered in Greece."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:ATU48426.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Ab4568 {ECO:0000313|EMBL:ATU55759.1}, Ab4653 RC {ECO:0000313|EMBL:ATU52040.1}, and Ab4977 RC {ECO:0000313|EMBL:ATU48426.1}; RA Liu X.; RT "Genome analysis of an Acinetobacter baumannii outbreak in hospital RT ICU in China."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:ATU23859.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AYP-A2 {ECO:0000313|EMBL:ATU23859.1}; RA Hawkey J., Judd L., Kostoulias X., Ascher D., Wick R., Peleg A., RA Holt K.E.; RT "Microevolution of Acinetobacter baumannii on a single patient."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [31] {ECO:0000313|EMBL:ATR87285.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AbPK1 {ECO:0000313|EMBL:ATR87285.1}; RA Banno H., Chua N.-H.; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. RN [32] {ECO:0000313|EMBL:PIN37871.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=VB17782 {ECO:0000313|EMBL:PIN41728.1}, VB2265 RC {ECO:0000313|EMBL:PIN49471.1}, VB23193 {ECO:0000313|EMBL:PIN37871.1}, RC and VB3373 {ECO:0000313|EMBL:PIN45170.1}; RA Veeraraghavan B., Vijayakumar S., M S D.P., I F.Y.; RT "Colistin Resistant Acinetobacter baumannii."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. RN [33] {ECO:0000313|EMBL:PIL59175.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MBL_M2 {ECO:0000313|EMBL:PIL59175.1}; RA Nadia J., Bonnin R., Mansour W., Weslati S., Kalboussi N., RA Boujaafar N., Bouallegue O., Naas T.; RT "Dissemination and characterization of NDM-producing Acinetobacter RT baumannii in a teaching hospital in Tunisia."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Release of N-terminal amino acids, CC preferentially methionine, from peptides and arylamides. CC {ECO:0000256|HAMAP-Rule:MF_01974, ECO:0000256|RuleBase:RU003653}. CC -!- COFACTOR: CC Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; CC Note=Binds 2 divalent metal cations per subunit. Has a high- CC affinity and a low affinity metal-binding site. The true nature of CC the physiological cofactor is under debate. The enzyme is active CC with cobalt, zinc, manganese or divalent iron ions. Most likely, CC methionine aminopeptidases function as mononuclear Fe(2+)- CC metalloproteases under physiological conditions, and the CC catalytically relevant metal-binding site has been assigned to the CC histidine-containing high-affinity site. {ECO:0000256|HAMAP- CC Rule:MF_01974, ECO:0000256|RuleBase:RU003653}; CC -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_01974}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP009257; AIL78573.1; -; Genomic_DNA. DR EMBL; CP008706; AKA30982.1; -; Genomic_DNA. DR EMBL; CP014528; AMN02327.1; -; Genomic_DNA. DR EMBL; CP021782; ASF78035.1; -; Genomic_DNA. DR EMBL; CP024418; ATP86485.1; -; Genomic_DNA. DR EMBL; CP024576; ATR87285.1; -; Genomic_DNA. DR EMBL; CP024124; ATU23859.1; -; Genomic_DNA. DR EMBL; CP024611; ATU48426.1; -; Genomic_DNA. DR EMBL; CP024612; ATU52040.1; -; Genomic_DNA. DR EMBL; CP024613; ATU55759.1; -; Genomic_DNA. DR EMBL; CVLF01000087; CQR89265.1; -; Genomic_DNA. DR EMBL; LFYZ01000001; KMV05062.1; -; Genomic_DNA. DR EMBL; LLFE01000041; KQD20501.1; -; Genomic_DNA. DR EMBL; LRDW01000036; KZA22651.1; -; Genomic_DNA. DR EMBL; MDWM01000086; ODP71121.1; -; Genomic_DNA. DR EMBL; LYIX01002080; OIF74617.1; -; Genomic_DNA. DR EMBL; LYKI01000023; OIG72371.1; -; Genomic_DNA. DR EMBL; LYKQ01000028; OIH08354.1; -; Genomic_DNA. DR EMBL; MTGG01000011; OOD23107.1; -; Genomic_DNA. DR EMBL; NGCH01000216; OTL50035.1; -; Genomic_DNA. DR EMBL; NGEL01000129; OTM85450.1; -; Genomic_DNA. DR EMBL; NCYH01000005; OVL12321.1; -; Genomic_DNA. DR EMBL; NGKM01000001; OWK68248.1; -; Genomic_DNA. DR EMBL; LYNJ01000237; OWW98854.1; -; Genomic_DNA. DR EMBL; NOXP01000002; OZT31344.1; -; Genomic_DNA. DR EMBL; NKKG01000021; PAM74467.1; -; Genomic_DNA. DR EMBL; NNSI01000308; PHM79701.1; -; Genomic_DNA. DR EMBL; NNSJ01000204; PHM87017.1; -; Genomic_DNA. DR EMBL; NXGU01000047; PHP82810.1; -; Genomic_DNA. DR EMBL; NXDV01000014; PHQ01666.1; -; Genomic_DNA. DR EMBL; MWTR01000043; PIL50289.1; -; Genomic_DNA. DR EMBL; MWTU01000115; PIL55402.1; -; Genomic_DNA. DR EMBL; MWTT01000189; PIL57427.1; -; Genomic_DNA. DR EMBL; MWTS01000459; PIL59175.1; -; Genomic_DNA. DR EMBL; MWTW01000174; PIL65147.1; -; Genomic_DNA. DR EMBL; MWTV01000402; PIL67103.1; -; Genomic_DNA. DR EMBL; MWTX01000011; PIL76819.1; -; Genomic_DNA. DR EMBL; MWTZ01000173; PIL77371.1; -; Genomic_DNA. DR EMBL; MWUA01000043; PIL82665.1; -; Genomic_DNA. DR EMBL; MWUB01000220; PIL88249.1; -; Genomic_DNA. DR EMBL; PESR01000007; PIN37871.1; -; Genomic_DNA. DR EMBL; PESS01000007; PIN41728.1; -; Genomic_DNA. DR EMBL; PEST01000009; PIN45170.1; -; Genomic_DNA. DR EMBL; PESU01000006; PIN49471.1; -; Genomic_DNA. DR RefSeq; WP_001089491.1; NZ_NXHM01000014.1. DR EnsemblBacteria; AIL78573; AIL78573; IX87_07995. DR EnsemblBacteria; AKA30982; AKA30982; ABUW_1234. DR EnsemblBacteria; AKQ26271; AKQ26271; ACX60_05910. DR EnsemblBacteria; AMN02327; AMN02327; AZE33_14285. DR EnsemblBacteria; BAP65968; BAP65968; IOMTU433_1184. DR EnsemblBacteria; KMV05062; KMV05062; AB895_0353. DR EnsemblBacteria; KMV10717; KMV10717; AB988_0028. DR EnsemblBacteria; KQD20501; KQD20501; APD06_11055. DR EnsemblBacteria; KQK46469; KQK46469; AQ482_07905. DR EnsemblBacteria; KUI76164; KUI76164; AQ480_02225. DR EnsemblBacteria; KZA22651; KZA22651; LV38_03303. DR EnsemblBacteria; OBE59901; OBE59901; A7934_09120. DR EnsemblBacteria; ODP71121; ODP71121; BGC29_02575. DR GeneID; 31348596; -. DR KEGG; abaa:IX88_14615; -. DR KEGG; abau:IX87_07995; -. DR KEGG; abk:LX00_12565; -. DR KEGG; abw:BL01_08915; -. DR PATRIC; fig|470.1288.peg.1761; -. DR eggNOG; ENOG4105CA1; Bacteria. DR eggNOG; COG0024; LUCA. DR KO; K01265; -. DR Proteomes; UP000028932; Chromosome. DR Proteomes; UP000032746; Chromosome. DR Proteomes; UP000036720; Unassembled WGS sequence. DR Proteomes; UP000051322; Unassembled WGS sequence. DR Proteomes; UP000070590; Chromosome. DR Proteomes; UP000076314; Unassembled WGS sequence. DR Proteomes; UP000094982; Unassembled WGS sequence. DR Proteomes; UP000179770; Unassembled WGS sequence. DR Proteomes; UP000179791; Unassembled WGS sequence. DR Proteomes; UP000179937; Unassembled WGS sequence. DR Proteomes; UP000188718; Unassembled WGS sequence. DR Proteomes; UP000194699; Unassembled WGS sequence. DR Proteomes; UP000194957; Unassembled WGS sequence. DR Proteomes; UP000195460; Unassembled WGS sequence. DR Proteomes; UP000197394; Unassembled WGS sequence. DR Proteomes; UP000197701; Chromosome. DR Proteomes; UP000216072; Unassembled WGS sequence. DR Proteomes; UP000216874; Unassembled WGS sequence. DR Proteomes; UP000221207; Unassembled WGS sequence. DR Proteomes; UP000223291; Unassembled WGS sequence. DR Proteomes; UP000223836; Unassembled WGS sequence. DR Proteomes; UP000225909; Unassembled WGS sequence. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0070084; P:protein initiator methionine removal; IEA:UniProtKB-UniRule. DR CDD; cd01086; MetAP1; 1. DR HAMAP; MF_01974; MetAP_1; 1. DR InterPro; IPR036005; Creatinase/aminopeptidase-like. DR InterPro; IPR000994; Pept_M24. DR InterPro; IPR001714; Pept_M24_MAP. DR InterPro; IPR002467; Pept_M24A_MAP1. DR Pfam; PF00557; Peptidase_M24; 1. DR PRINTS; PR00599; MAPEPTIDASE. DR SUPFAM; SSF55920; SSF55920; 1. DR TIGRFAMs; TIGR00500; met_pdase_I; 1. DR PROSITE; PS00680; MAP_1; 1. PE 3: Inferred from homology; KW Aminopeptidase {ECO:0000256|HAMAP-Rule:MF_01974, KW ECO:0000256|RuleBase:RU003653, ECO:0000313|EMBL:KQD20501.1}; KW Complete proteome {ECO:0000313|Proteomes:UP000028932, KW ECO:0000313|Proteomes:UP000032746, ECO:0000313|Proteomes:UP000036720, KW ECO:0000313|Proteomes:UP000051322}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01974, KW ECO:0000313|EMBL:KQD20501.1}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01974, KW ECO:0000256|RuleBase:RU003653}; KW Protease {ECO:0000256|HAMAP-Rule:MF_01974, KW ECO:0000256|RuleBase:RU003653}. FT DOMAIN 19 256 Peptidase_M24. {ECO:0000259|Pfam: FT PF00557}. FT METAL 110 110 Divalent metal cation 1. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT METAL 121 121 Divalent metal cation 1. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT METAL 121 121 Divalent metal cation 2; catalytic. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT METAL 185 185 Divalent metal cation 2; catalytic; via FT tele nitrogen. {ECO:0000256|HAMAP-Rule: FT MF_01974}. FT METAL 218 218 Divalent metal cation 2; catalytic. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT METAL 249 249 Divalent metal cation 1. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT METAL 249 249 Divalent metal cation 2; catalytic. FT {ECO:0000256|HAMAP-Rule:MF_01974}. FT BINDING 92 92 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_01974}. FT BINDING 192 192 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_01974}. SQ SEQUENCE 275 AA; 30374 MW; 6D82AB2AE6DC1802 CRC64; MNSTYTAPRR LIKTPDEIEK MRIAGRLAAE VLDMIKPHIK AGVSTLELDT ICRNHIENVQ HAIPACVGYG GAPGRPAFQH SICTSVNHVV CHGIPSENKI LKNGDILNID VTVIKDGYHG DTNMMYIVGG ETSILANRLC KVAQEAMYRG MATVRDGSYL GDIGHAIQKY VESERFSVVR EYCGHGIGTV FHDEPQVLHY GQAGTGMRLE AGMTFTIEPM VNAGVWQTKL LGDKWTVVTK DHKLSAQYEH TILVTKTGIE VLTARPEEDL SRFNQ //