ID   V5V8R9_ACIBA            Unreviewed;       373 AA.
AC   V5V8R9;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=3,4-dihydroxy-2-butanone 4-phosphate synthase {ECO:0000256|ARBA:ARBA00018836, ECO:0000256|HAMAP-Rule:MF_00180};
DE            Short=DHBP synthase {ECO:0000256|HAMAP-Rule:MF_00180};
DE            EC=4.1.99.12 {ECO:0000256|ARBA:ARBA00012153, ECO:0000256|HAMAP-Rule:MF_00180};
GN   Name=ribB {ECO:0000256|HAMAP-Rule:MF_00180,
GN   ECO:0000313|EMBL:PZM14947.1};
GN   Synonyms=gTP-1 {ECO:0000313|EMBL:QEE55631.1}, ribBA
GN   {ECO:0000313|EMBL:SST16526.1};
GN   ORFNames=A7M90_07480 {ECO:0000313|EMBL:OIG69364.1}, AB945B12_02177
GN   {ECO:0000313|EMBL:CAA0231046.1}, Aba9201_14160
GN   {ECO:0000313|EMBL:AXX42063.1}, ABCAM1_3609
GN   {ECO:0000313|EMBL:QEY05948.1}, ABKPCSM17A_01836
GN   {ECO:0000313|EMBL:CAA0217281.1}, ABR2091_3594
GN   {ECO:0000313|EMBL:CUW36951.1}, ACX61_00450
GN   {ECO:0000313|EMBL:AKQ28926.1}, APC21_15860
GN   {ECO:0000313|EMBL:KQF72609.1}, APD31_17150
GN   {ECO:0000313|EMBL:KQD97727.1}, AUO97_07790
GN   {ECO:0000313|EMBL:APP30717.1}, BAA1790NC_0089
GN   {ECO:0000313|EMBL:QEE55631.1}, C2U32_13770
GN   {ECO:0000313|EMBL:AUT38984.1}, CBE85_14000
GN   {ECO:0000313|EMBL:OWK65902.1}, CPI82_04655
GN   {ECO:0000313|EMBL:PHQ04161.1}, D8O08_001735
GN   {ECO:0000313|EMBL:QBF35280.1}, DLI71_12180
GN   {ECO:0000313|EMBL:QFX72326.1}, DOL94_13630
GN   {ECO:0000313|EMBL:PZM14947.1}, E1A86_00665
GN   {ECO:0000313|EMBL:QBM39328.1}, E1A87_06455
GN   {ECO:0000313|EMBL:QBM43772.1}, EA706_08740
GN   {ECO:0000313|EMBL:RSQ44819.1}, EA722_13980
GN   {ECO:0000313|EMBL:RSP73049.1}, EGM95_00550
GN   {ECO:0000313|EMBL:AYY87368.1}, EWO96_09665
GN   {ECO:0000313|EMBL:RYL30417.1}, F4T85_08815
GN   {ECO:0000313|EMBL:MQZ68491.1}, FDN00_00910
GN   {ECO:0000313|EMBL:QCP40564.1}, FJU36_16295
GN   {ECO:0000313|EMBL:TPU76920.1}, FJU76_07355
GN   {ECO:0000313|EMBL:TPS95098.1}, FR761_00440
GN   {ECO:0000313|EMBL:QFH43987.1}, G3N53_07915
GN   {ECO:0000313|EMBL:NDW40999.1}, GSE42_19585
GN   {ECO:0000313|EMBL:MYM80115.1}, H0529_16840
GN   {ECO:0000313|EMBL:QOJ59340.1}, H1058_17985
GN   {ECO:0000313|EMBL:MBA2960123.1}, HB367_13910
GN   {ECO:0000313|EMBL:QJG84967.1}, HBK86_17530
GN   {ECO:0000313|EMBL:QJH22983.1}, HIN86_00455
GN   {ECO:0000313|EMBL:QJF33822.1}, ITE13_03455
GN   {ECO:0000313|EMBL:MBP4958571.1}, NCTC13305_02541
GN   {ECO:0000313|EMBL:SUU29419.1}, SAMEA104305318_00510
GN   {ECO:0000313|EMBL:SST16526.1}, SAMEA104305340_03014
GN   {ECO:0000313|EMBL:SSU16033.1}, SAMEA104305385_01284
GN   {ECO:0000313|EMBL:SSU80259.1}, SI89_11175
GN   {ECO:0000313|EMBL:NBG85133.1};
OS   Acinetobacter baumannii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470 {ECO:0000313|EMBL:PZM14947.1, ECO:0000313|Proteomes:UP000248662};
RN   [1] {ECO:0000313|EMBL:APP30717.1, ECO:0000313|Proteomes:UP000072389}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP30717.1,
RC   ECO:0000313|Proteomes:UP000072389};
RX   PubMed=25136007; DOI=10.1128/AAC.03074-14;
RA   Fernando D.M., Xu W., Loewen P.C., Zhanel G.G., Kumar A.;
RT   "Triclosan can select for an AdeIJK-overexpressing mutant of Acinetobacter
RT   baumannii ATCC 17978 that displays reduced susceptibility to multiple
RT   antibiotics.";
RL   Antimicrob. Agents Chemother. 58:6424-6431(2014).
RN   [2] {ECO:0000313|EMBL:AKQ28926.1, ECO:0000313|Proteomes:UP000036348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ab04-mff {ECO:0000313|EMBL:AKQ28926.1,
RC   ECO:0000313|Proteomes:UP000036348};
RX   PubMed=26170289; DOI=10.1073/pnas.1502966112;
RA   Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT   "A multidrug resistance plasmid contains the molecular switch for type VI
RT   secretion in Acinetobacter baumannii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:9442-9447(2015).
RN   [3] {ECO:0000313|Proteomes:UP000036348}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ab04-mff {ECO:0000313|Proteomes:UP000036348};
RA   Weber B.S., Ly P.M., Irwin J.N., Pukatzki S., Feldman M.F.;
RT   "A multidrug resistance plasmid contains the molecular switch for type VI
RT   secretion in Acinetobacter baumannii.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000050848, ECO:0000313|Proteomes:UP000050896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABBL070 {ECO:0000313|EMBL:KQD97727.1,
RC   ECO:0000313|Proteomes:UP000050896}, and ABBL127
RC   {ECO:0000313|EMBL:KQF72609.1, ECO:0000313|Proteomes:UP000050848};
RA   Ozer E.A., Fitzpatrick M.A., Hauser A.R.;
RT   "The utility of whole genome sequencing in characterizing Acinetobacter
RT   epidemiology and analyzing hospital outbreaks.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:APP30717.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP30717.1};
RA   Singh M.K., Fernando D.M., Kumar A.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:CUW36951.1, ECO:0000313|Proteomes:UP000066661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R2091 {ECO:0000313|EMBL:CUW36951.1};
RA   Wibberg D.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000293712, ECO:0000313|Proteomes:UP000294205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB047 {ECO:0000313|EMBL:QBM39328.1,
RC   ECO:0000313|Proteomes:UP000294205}, and AB048
RC   {ECO:0000313|EMBL:QBM43772.1, ECO:0000313|Proteomes:UP000293712};
RX   PubMed=27917170; DOI=.3389/fmicb.2016.01871;
RA   Fernando D.M., Khan I.U., Patidar R., Lapen D.R., Talbot G., Topp E.,
RA   Kumar A.;
RT   "Isolation and Characterization of Acinetobacter baumannii Recovered from
RT   Campylobacter Selective Medium.";
RL   Front. Microbiol. 7:1871-1871(2016).
RN   [8] {ECO:0000313|EMBL:OIG69364.1, ECO:0000313|Proteomes:UP000179937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XH647 {ECO:0000313|EMBL:OIG69364.1,
RC   ECO:0000313|Proteomes:UP000179937};
RA   Hua X., Yu Y.;
RT   "The evolution of Acinetobacter baumannii in vivo.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:APP30717.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 17978 {ECO:0000313|EMBL:APP30717.1};
RA   Singh M., Fernando D., Kumar A.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:MYM80115.1, ECO:0000313|Proteomes:UP000480763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DMS06669 {ECO:0000313|EMBL:MYM80115.1,
RC   ECO:0000313|Proteomes:UP000480763};
RX   PubMed=29137647;
RA   Si-Tuan N., Ngoc H.M., Hang P.T.T., Nguyen C., Van P.H., Huong N.T.;
RT   "New eight genes identified at the clinical multidrug-resistant
RT   Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.";
RL   Ann. Clin. Microbiol. Antimicrob. 16:0-74(2017).
RN   [11] {ECO:0000313|EMBL:OWK65902.1, ECO:0000313|Proteomes:UP000197394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB360 {ECO:0000313|EMBL:OWK65902.1,
RC   ECO:0000313|Proteomes:UP000197394};
RA   Wareham D.W., Bean D.C.;
RT   "Draft genome sequence of MDR A. baumannii AB360.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AXX42063.1, ECO:0000313|Proteomes:UP000261834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9201 {ECO:0000313|EMBL:AXX42063.1,
RC   ECO:0000313|Proteomes:UP000261834};
RA   Salgado-Camargo A.D., Castro-Jaimes S., Silva-Sanchez J.,
RA   Volkow-Fernandez P., Castillo-Ramirez S., Cevallos M.A.;
RT   "Evolution of Acinetobacter baumannii plasmids.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:PHQ04161.1, ECO:0000313|Proteomes:UP000223291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=I43 {ECO:0000313|EMBL:PHQ04161.1,
RC   ECO:0000313|Proteomes:UP000223291};
RA   Siqueira K.A., Mello I.S., Mendes T.A., Soares M.A.;
RT   "Draft genome of Acinetobacter baumannii strain I43, a mercury resistant
RT   bacteria.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-e02017(2018).
RN   [15] {ECO:0000313|EMBL:AUT38984.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38984.1};
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:AUT38984.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|EMBL:AUT38984.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|Proteomes:UP000236385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ABNIH28 {ECO:0000313|Proteomes:UP000236385};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:PZM14947.1, ECO:0000313|Proteomes:UP000248662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R10 {ECO:0000313|EMBL:PZM14947.1,
RC   ECO:0000313|Proteomes:UP000248662};
RA   Bonnin R.A., Levy M., Cuzon G., Dortet L., Naas T.;
RT   "Carbapenemase-producing Acinetobacter spp. from environmental sources in
RT   an hospital from French Polynesia.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:SUU29419.1, ECO:0000313|Proteomes:UP000255154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13305 {ECO:0000313|EMBL:SUU29419.1,
RC   ECO:0000313|Proteomes:UP000255154};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|Proteomes:UP000252290, ECO:0000313|Proteomes:UP000252694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY7045823 {ECO:0000313|EMBL:SST16526.1,
RC   ECO:0000313|Proteomes:UP000252694}, 4300STDY7045845
RC   {ECO:0000313|EMBL:SSU16033.1, ECO:0000313|Proteomes:UP000252290}, and
RC   4300STDY7045886 {ECO:0000313|EMBL:SSU80259.1,
RC   ECO:0000313|Proteomes:UP000253280};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|Proteomes:UP000269597, ECO:0000313|Proteomes:UP000272401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TG22168 {ECO:0000313|EMBL:RSQ44819.1,
RC   ECO:0000313|Proteomes:UP000272401}, and TG31299
RC   {ECO:0000313|EMBL:RSP73049.1, ECO:0000313|Proteomes:UP000269597};
RA   Sahl J.W.;
RT   "GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance
RT   in Acinetobacter baumannii.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|EMBL:AYY87368.1, ECO:0000313|Proteomes:UP000273577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY87368.1,
RC   ECO:0000313|Proteomes:UP000273577};
RA   Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA   Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT   "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT   Acinetobacter baumannii clinical strain.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0007829|PDB:6MNZ}
RP   X-RAY CRYSTALLOGRAPHY (2.66 ANGSTROMS).
RX   PubMed=30905682; DOI=10.1016/j.chembiol.2019.02.011;
RA   Wang J., Lonergan Z.R., Gonzalez-Gutierrez G., Nairn B.L., Maxwell C.N.,
RA   Zhang Y., Andreini C., Karty J.A., Chazin W.J., Trinidad J.C., Skaar E.P.,
RA   Giedroc D.P.;
RT   "Multi-metal Restriction by Calprotectin Impacts De Novo Flavin
RT   Biosynthesis in Acinetobacter baumannii.";
RL   Cell Chem. Biol. 26:745-755.e7(2019).
RN   [24] {ECO:0000313|EMBL:RYL30417.1, ECO:0000313|Proteomes:UP000292081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C1T1-2_b {ECO:0000313|EMBL:RYL30417.1,
RC   ECO:0000313|Proteomes:UP000292081};
RA   Rehman M.A.;
RT   "Whole-Genome Sequences of Acinetobacter spp Isolated From Dairy Cow
RT   Manure.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|EMBL:QBF35280.1, ECO:0000313|Proteomes:UP000270202}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VB31459 {ECO:0000313|EMBL:QBF35280.1,
RC   ECO:0000313|Proteomes:UP000270202};
RA   Veeraraghavan B., Vijayakumar S., Neeravi A., Venkatesan M.;
RT   "Carbapenem resistant Acinetobacter baumannii_VB31459_hybrid assembly.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:QBM39328.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AB047 {ECO:0000313|EMBL:QBM39328.1}, and AB048
RC   {ECO:0000313|EMBL:QBM43772.1};
RA   Singh M.K., Patidar R., Khan I., Kumar A.;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|EMBL:QCP40564.1, ECO:0000313|Proteomes:UP000298622}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VB33071 {ECO:0000313|EMBL:QCP40564.1,
RC   ECO:0000313|Proteomes:UP000298622};
RA   Veeraraghavan B., Vijayakumar S., Vasudevan K., Narasimman V.,
RA   Venkatesan M.;
RT   "Carbapenem resistant Acinetobacter baumannii_VB33071_hybrid assembly.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|Proteomes:UP000318271, ECO:0000313|Proteomes:UP000320149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSN14427 {ECO:0000313|EMBL:TPU76920.1,
RC   ECO:0000313|Proteomes:UP000320149}, and MRSN32875
RC   {ECO:0000313|EMBL:TPS95098.1, ECO:0000313|Proteomes:UP000318271};
RA   Mcgann P., Snesrud E., Galac M.R.;
RT   "A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|EMBL:QEE55631.1, ECO:0000313|Proteomes:UP000321690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1790 {ECO:0000313|EMBL:QEE55631.1,
RC   ECO:0000313|Proteomes:UP000321690};
RA   Joubert M., Magabota S.M., Reva O.N., Korotetskiy I.S., Jumagaziyeva A.B.,
RA   Shilov S.V., Shvidko S.V., Kenesheva S.T., Suldina N.A., Ilin A.I.;
RT   "Acinetobacter baumannii genome sequencing and assembly.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:QFH43987.1, ECO:0000313|Proteomes:UP000327158}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E47 {ECO:0000313|EMBL:QFH43987.1,
RC   ECO:0000313|Proteomes:UP000327158};
RA   Phan H.T.T., Stoesser N., Gordon K.A., Crook D., Walker S.A., Mathers A.J.,
RA   Peto T.E.A., George S., Lipworth S.I.;
RT   "Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged
RT   blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|EMBL:QFX72326.1, ECO:0000313|Proteomes:UP000325982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6507 {ECO:0000313|EMBL:QFX72326.1,
RC   ECO:0000313|Proteomes:UP000325982};
RA   Paul V., Sankar M.J., Gaind R., Ray P., Gautam V., Biswal M., Datta S.,
RA   Walia K., Kreiswirth B., Evans S., Fowler V., Patel R., Chambers H.C.,
RA   Bonomo R.A., Hujer K.M., Huker A., Adams M., Clarke T.H., Sutton G.,
RA   Nierman W.C., Nelson K.E., Fouts D.E.;
RT   "10 Multi-Drug Resistant Acinetobacter Baumannii Strains for ARLG-ICMR From
RT   India.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|EMBL:MQZ68491.1, ECO:0000313|Proteomes:UP000420346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AMA26 {ECO:0000313|EMBL:MQZ68491.1,
RC   ECO:0000313|Proteomes:UP000420346};
RA   Maria R.S., Adams M.D.;
RT   "Distinct mechanisms of dissemination of NDM-1 metallo-beta-betalactamase
RT   in Acinetobacter species spp. in Argentina.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|EMBL:QEY05948.1, ECO:0000313|Proteomes:UP000326895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAM180-1 {ECO:0000313|EMBL:QEY05948.1,
RC   ECO:0000313|Proteomes:UP000326895};
RA   Kim Y.-H., Kim B.K.;
RT   "Genome sequencing of Acinetobacter baumannii strain CAM180.";
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN   [34] {ECO:0000313|EMBL:NBG85133.1, ECO:0000313|Proteomes:UP000460226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NFAb1 {ECO:0000313|EMBL:NBG85133.1,
RC   ECO:0000313|Proteomes:UP000460226};
RA   Arivett B.A., Charnot-Katsikas A., Bethel C., Fiester S.E., Actis L.A.;
RT   "Draft Genomes of Two Acinetobacter baumannii Isolates from Fatal
RT   Necrotizing Fasciitis.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [35] {ECO:0000313|EMBL:MYM80115.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DMS06669 {ECO:0000313|EMBL:MYM80115.1};
RA   Nguyen S.-T.;
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [36] {ECO:0000313|Proteomes:UP000445311, ECO:0000313|Proteomes:UP000445317}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=945B12-12AESBL {ECO:0000313|EMBL:CAA0231046.1,
RC   ECO:0000313|Proteomes:UP000445317}, and KPC-SM-17a
RC   {ECO:0000313|EMBL:CAA0217281.1, ECO:0000313|Proteomes:UP000445311};
RA   Blom J.;
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [37] {ECO:0000313|EMBL:NDW40999.1, ECO:0000313|Proteomes:UP000470018}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP816 {ECO:0000313|EMBL:NDW40999.1,
RC   ECO:0000313|Proteomes:UP000470018};
RA   Veeraraghavan B., Mathur P., Vijayakumar S., Vasudevan K., Lincy M.,
RA   Kirubananthan A.;
RT   "Whole genome shot-gun sequencing of clinical Carbapenem resistant A.
RT   baumannii.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [38] {ECO:0000313|EMBL:QJH22983.1, ECO:0000313|Proteomes:UP000502990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VB82 {ECO:0000313|EMBL:QJH22983.1,
RC   ECO:0000313|Proteomes:UP000502990};
RA   Veeraraghavan B., Vijayakumar S., Amala A., Francis L., Kirubananthan A.;
RT   "Complete genome of Carbapenem Resistant Acinetobacter baumannii.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [39] {ECO:0000313|Proteomes:UP000503033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PM193665 {ECO:0000313|Proteomes:UP000503033};
RA   Veeraraghavan B., Vijayakumar S., Amala A., francis L., Kirubananthan A.;
RT   "Complete genome sequencing for A.baumanii.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [40] {ECO:0000313|EMBL:QJG84967.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PM193665 {ECO:0000313|EMBL:QJG84967.1};
RA   Veeraraghavan B., Vijayakumar S., Amala A., Francis L., Kirubananthan A.;
RT   "Complete genome sequencing for A.baumanii.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [41] {ECO:0000313|EMBL:QJF33822.1, ECO:0000313|Proteomes:UP000501210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ab-B004d-c {ECO:0000313|EMBL:QJF33822.1,
RC   ECO:0000313|Proteomes:UP000501210};
RA   Ayibieke A., Saito R.;
RT   "Whole-genome sequence analysis of carbapanemase producing Acinetobacter
RT   baumannii isolates from Ghana.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [42] {ECO:0000313|EMBL:MBA2960123.1, ECO:0000313|Proteomes:UP000537494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A217 {ECO:0000313|EMBL:MBA2960123.1,
RC   ECO:0000313|Proteomes:UP000537494};
RA   Chopjitt P., Wongsurawat T., Jenjaroenpun P., Boueroy P., Hatrongjit R.,
RA   Kerdsin A.;
RT   "Complete Genome Sequence of Four Extensively Drug-Resistant Acinetobacter
RT   buamannii Isolated from Clinical Samples in Thailand.";
RL   Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN   [43] {ECO:0000313|Proteomes:UP000593752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AC1633 {ECO:0000313|Proteomes:UP000593752};
RA   Alattraqchi A.G., Mohd Ranii, F, A Rahmann, NII, Ismail S., Cleary D.,
RA   Clarke S., Yeo C.C.;
RT   "Complete genome sequencing of Acinetobacter baumannii AC1633 and
RT   Acinetobacter nosocomialis AC1530 unveils a large multidrug resistant
RT   plasmid encoding the NDM-1 and OXA-58 carbapenemases.";
RL   Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN   [44] {ECO:0000313|EMBL:MBP4958571.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E314 {ECO:0000313|EMBL:MBP4958571.1};
RA   Frenk S., Rakovitsky N.;
RT   "Epidemiology and genetic characterization of 247 CRAB isolated from
RT   infections.";
RL   Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN   [45] {ECO:0000313|EMBL:QOJ59340.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AC1633 {ECO:0000313|EMBL:QOJ59340.1};
RA   Alattraqchi A.G., Mohd Rani F., A. Rahman N.I., Ismail S., Cleary D.W.,
RA   Clarke S.C., Yeo C.C.;
RT   "Complete Genome Sequencing of Acinetobacter baumannii AC1633 and
RT   Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant
RT   Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases.";
RL   MSphere 6:0-0(2021).
CC   -!- FUNCTION: Catalyzes the conversion of D-ribulose 5-phosphate to formate
CC       and 3,4-dihydroxy-2-butanone 4-phosphate.
CC       {ECO:0000256|ARBA:ARBA00002284, ECO:0000256|HAMAP-Rule:MF_00180}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate +
CC         formate + H(+); Xref=Rhea:RHEA:18457, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:58121, ChEBI:CHEBI:58830;
CC         EC=4.1.99.12; Evidence={ECO:0000256|ARBA:ARBA00000141,
CC         ECO:0000256|HAMAP-Rule:MF_00180};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00180};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00180};
CC       Note=Binds 2 divalent metal cations per subunit. Magnesium or
CC       manganese. {ECO:0000256|HAMAP-Rule:MF_00180};
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-
CC       oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004904, ECO:0000256|HAMAP-Rule:MF_00180}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00180}.
CC   -!- SIMILARITY: Belongs to the DHBP synthase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00180}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the GTP
CC       cyclohydrolase II family. {ECO:0000256|ARBA:ARBA00008976}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the DHBP synthase
CC       family. {ECO:0000256|ARBA:ARBA00005520}.
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DR   EMBL; CP012006; AKQ28926.1; -; Genomic_DNA.
DR   EMBL; CP018664; APP30717.1; -; Genomic_DNA.
DR   EMBL; CP026125; AUT38984.1; -; Genomic_DNA.
DR   EMBL; CP023020; AXX42063.1; -; Genomic_DNA.
DR   EMBL; CP033869; AYY87368.1; -; Genomic_DNA.
DR   EMBL; CACSGV010000028; CAA0217281.1; -; Genomic_DNA.
DR   EMBL; CACSGI010000025; CAA0231046.1; -; Genomic_DNA.
DR   EMBL; LN997846; CUW36951.1; -; Genomic_DNA.
DR   EMBL; LLGA01000064; KQD97727.1; -; Genomic_DNA.
DR   EMBL; LLHX01000379; KQF72609.1; -; Genomic_DNA.
DR   EMBL; JACEIH010000001; MBA2960123.1; -; Genomic_DNA.
DR   EMBL; JAEHMK010000004; MBP4958571.1; -; Genomic_DNA.
DR   EMBL; VYTH01000010; MQZ68491.1; -; Genomic_DNA.
DR   EMBL; WWCH01000001; MYM80115.1; -; Genomic_DNA.
DR   EMBL; WKJR01000030; NBG85133.1; -; Genomic_DNA.
DR   EMBL; JAAGTY010000007; NDW40999.1; -; Genomic_DNA.
DR   EMBL; LYKI01000045; OIG69364.1; -; Genomic_DNA.
DR   EMBL; NGKM01000015; OWK65902.1; -; Genomic_DNA.
DR   EMBL; NXDV01000002; PHQ04161.1; -; Genomic_DNA.
DR   EMBL; QKWF01000149; PZM14947.1; -; Genomic_DNA.
DR   EMBL; CP035930; QBF35280.1; -; Genomic_DNA.
DR   EMBL; CP037871; QBM39328.1; -; Genomic_DNA.
DR   EMBL; CP037870; QBM43772.1; -; Genomic_DNA.
DR   EMBL; CP040084; QCP40564.1; -; Genomic_DNA.
DR   EMBL; CP042841; QEE55631.1; -; Genomic_DNA.
DR   EMBL; CP044356; QEY05948.1; -; Genomic_DNA.
DR   EMBL; CP042556; QFH43987.1; -; Genomic_DNA.
DR   EMBL; CP045528; QFX72326.1; -; Genomic_DNA.
DR   EMBL; CP051875; QJF33822.1; -; Genomic_DNA.
DR   EMBL; CP050415; QJG84967.1; -; Genomic_DNA.
DR   EMBL; CP050385; QJH22983.1; -; Genomic_DNA.
DR   EMBL; CP059300; QOJ59340.1; -; Genomic_DNA.
DR   EMBL; RFBY01000049; RSP73049.1; -; Genomic_DNA.
DR   EMBL; RFCO01000034; RSQ44819.1; -; Genomic_DNA.
DR   EMBL; SEUE01000004; RYL30417.1; -; Genomic_DNA.
DR   EMBL; UFMQ01000001; SST16526.1; -; Genomic_DNA.
DR   EMBL; UFNM01000015; SSU16033.1; -; Genomic_DNA.
DR   EMBL; UFOF01000003; SSU80259.1; -; Genomic_DNA.
DR   EMBL; UFSC01000003; SUU29419.1; -; Genomic_DNA.
DR   EMBL; VHFD01000021; TPS95098.1; -; Genomic_DNA.
DR   EMBL; VHGX01000043; TPU76920.1; -; Genomic_DNA.
DR   RefSeq; WP_001131392.1; NZ_WYAT01000006.1.
DR   PDB; 6MNZ; X-ray; 2.66 A; A/B=1-373.
DR   PDBsum; 6MNZ; -.
DR   EnsemblBacteria; AUT38984; AUT38984; C2U32_13770.
DR   EnsemblBacteria; AYY87368; AYY87368; EGM95_00550.
DR   EnsemblBacteria; KZA29011; KZA29011; LV38_00273.
DR   EnsemblBacteria; ODP72607; ODP72607; BGC29_12000.
DR   EnsemblBacteria; OIG11073; OIG11073; A7N09_07660.
DR   EnsemblBacteria; OIG69364; OIG69364; A7M90_07480.
DR   EnsemblBacteria; OIH04060; OIH04060; A7M79_16415.
DR   EnsemblBacteria; OOD22443; OOD22443; BWP00_07280.
DR   EnsemblBacteria; OVL06505; OVL06505; B4R90_18035.
DR   EnsemblBacteria; OWK65902; OWK65902; CBE85_14000.
DR   EnsemblBacteria; OZT29416; OZT29416; CHQ89_12900.
DR   EnsemblBacteria; PHQ04161; PHQ04161; CPI82_04655.
DR   EnsemblBacteria; PUV04543; PUV04543; DCD77_13445.
DR   EnsemblBacteria; PZM14947; PZM14947; DOL94_13630.
DR   EnsemblBacteria; QAB38920; QAB38920; EHF38_00475.
DR   EnsemblBacteria; QBY15642; QBY15642; E4664_17405.
DR   EnsemblBacteria; QBY89813; QBY89813; E5D09_10300.
DR   EnsemblBacteria; QCP32736; QCP32736; FDF20_18095.
DR   EnsemblBacteria; RCU31527; RCU31527; DVA79_00360.
DR   EnsemblBacteria; RDJ58596; RDJ58596; AB719_10495.
DR   EnsemblBacteria; RIL17186; RIL17186; CYQ93_04890.
DR   EnsemblBacteria; SSM90325; SSM90325; SAMEA104305177_04327.
DR   EnsemblBacteria; SSS32275; SSS32275; SAMEA104305268_02187.
DR   EnsemblBacteria; SSS36729; SSS36729; SAMEA104305283_03505.
DR   EnsemblBacteria; SSS43523; SSS43523; SAMEA104305292_00936.
DR   EnsemblBacteria; SST16526; SST16526; SAMEA104305318_00510.
DR   EnsemblBacteria; SST83203; SST83203; SAMEA104305325_02394.
DR   EnsemblBacteria; SSU31718; SSU31718; SAMEA104305337_07510.
DR   EnsemblBacteria; SSU42902; SSU42902; SAMEA104305320_02498.
DR   EnsemblBacteria; SSU75100; SSU75100; SAMEA104305351_03114.
DR   EnsemblBacteria; SUU29419; SUU29419; NCTC13305_02541.
DR   EnsemblBacteria; SVJ99203; SVJ99203; SAMEA104305242_02556.
DR   GeneID; 66395427; -.
DR   PATRIC; fig|470.1289.peg.3680; -.
DR   OMA; ECRGLIC; -.
DR   UniPathway; UPA00275; UER00399.
DR   Proteomes; UP000036348; Chromosome.
DR   Proteomes; UP000050848; Unassembled WGS sequence.
DR   Proteomes; UP000050896; Unassembled WGS sequence.
DR   Proteomes; UP000066661; Chromosome I.
DR   Proteomes; UP000072389; Chromosome.
DR   Proteomes; UP000179937; Unassembled WGS sequence.
DR   Proteomes; UP000197394; Unassembled WGS sequence.
DR   Proteomes; UP000223291; Unassembled WGS sequence.
DR   Proteomes; UP000236385; Chromosome.
DR   Proteomes; UP000248662; Unassembled WGS sequence.
DR   Proteomes; UP000252290; Unassembled WGS sequence.
DR   Proteomes; UP000252694; Unassembled WGS sequence.
DR   Proteomes; UP000253280; Unassembled WGS sequence.
DR   Proteomes; UP000255154; Unassembled WGS sequence.
DR   Proteomes; UP000261834; Chromosome.
DR   Proteomes; UP000269597; Unassembled WGS sequence.
DR   Proteomes; UP000270202; Chromosome.
DR   Proteomes; UP000272401; Unassembled WGS sequence.
DR   Proteomes; UP000273577; Chromosome.
DR   Proteomes; UP000292081; Unassembled WGS sequence.
DR   Proteomes; UP000293712; Chromosome.
DR   Proteomes; UP000294205; Chromosome.
DR   Proteomes; UP000298622; Chromosome.
DR   Proteomes; UP000318271; Unassembled WGS sequence.
DR   Proteomes; UP000320149; Unassembled WGS sequence.
DR   Proteomes; UP000321690; Chromosome.
DR   Proteomes; UP000325982; Chromosome.
DR   Proteomes; UP000326895; Chromosome.
DR   Proteomes; UP000327158; Chromosome.
DR   Proteomes; UP000420346; Unassembled WGS sequence.
DR   Proteomes; UP000445311; Unassembled WGS sequence.
DR   Proteomes; UP000445317; Unassembled WGS sequence.
DR   Proteomes; UP000460226; Unassembled WGS sequence.
DR   Proteomes; UP000470018; Unassembled WGS sequence.
DR   Proteomes; UP000480763; Unassembled WGS sequence.
DR   Proteomes; UP000501210; Chromosome.
DR   Proteomes; UP000502990; Chromosome.
DR   Proteomes; UP000503033; Chromosome.
DR   Proteomes; UP000537494; Unassembled WGS sequence.
DR   Proteomes; UP000593752; Chromosome.
DR   Proteomes; UP000673677; Unassembled WGS sequence.
DR   GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10990; -; 1.
DR   HAMAP; MF_00180; RibB; 1.
DR   InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR   InterPro; IPR000422; DHBP_synthase_RibB.
DR   InterPro; IPR032677; GTP_cyclohydro_II.
DR   InterPro; IPR036144; RibA-like_sf.
DR   Pfam; PF00926; DHBP_synthase; 1.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   SUPFAM; SSF142695; SSF142695; 1.
DR   SUPFAM; SSF55821; SSF55821; 1.
DR   TIGRFAMs; TIGR00506; ribB; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6MNZ};
KW   Hydrolase {ECO:0000313|EMBL:PZM14947.1};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00180, ECO:0000313|EMBL:PZM14947.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00180};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_00180};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00180};
KW   Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619, ECO:0000256|HAMAP-
KW   Rule:MF_00180}.
FT   DOMAIN          210..365
FT                   /note="GTP_cyclohydro2"
FT                   /evidence="ECO:0000259|Pfam:PF00925"
FT   REGION          27..28
FT                   /note="D-ribulose 5-phosphate binding"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   REGION          140..144
FT                   /note="D-ribulose 5-phosphate binding"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   BINDING         28
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   BINDING         28
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   BINDING         32
FT                   /ligand="D-ribulose 5-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58121"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   BINDING         143
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   SITE            126
FT                   /note="Essential for catalytic activity"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
FT   SITE            164
FT                   /note="Essential for catalytic activity"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00180"
SQ   SEQUENCE   373 AA;  40899 MW;  EA7E0ADF7BD63089 CRC64;
     MPLSRVEELV ADIRAGKMVI LMDDEDRENE GDLVIAATHV RPEDINFMIT HARGLVCLTL
     SRERCKQLNL PLMVDQNGAQ HGTNFTLSIE AAEGITTGIS AAERAHTIQA AVAAHAKPTD
     IVQPGHIFPL MAQPGGVLHR AGHTEAGCDL ARLAGLEPAS VICEIIKEDG TMARRADLEI
     FAEKHGLKIG TIADLIHYRM TNEQTVERLD QRTIQTEYGS FELYRYREIG NPDIHLALVK
     GEPKEGVTTV RVHGFSPVRD LLKLNKADGE PAWNLDRALQ TIAASDRGVL VWIGQDHLQD
     LGPALDDLTK PKPVKSNAAL SHQYQTIGVG AQILRDLGVE KMKLLSSPLR FNALSGFNLE
     VVEYVTADQI TTK
//