ID V5TGF6_9FLAV Unreviewed; 618 AA. AC V5TGF6; DT 19-FEB-2014, integrated into UniProtKB/TrEMBL. DT 19-FEB-2014, sequence version 1. DT 17-FEB-2016, entry version 13. DE RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00058068}; DE Flags: Fragment; OS Dengue virus. OC Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; OC Flaviviridae; Flavivirus; Dengue virus group. OX NCBI_TaxID=12637 {ECO:0000313|EMBL:AHB63926.1}; RN [1] {ECO:0000313|EMBL:AHB63926.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DENV-2/PK {ECO:0000313|EMBL:AHB63926.1}; RA Akram M., Idrees M., Fatima Z.; RT "Complete genome sequence of Dengue serotype 2 isolated in Pakistan."; RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate CC + RNA(n+1). {ECO:0000256|SAAS:SAAS00057834}. CC -!- SIMILARITY: Contains RdRp catalytic domain. CC {ECO:0000256|SAAS:SAAS00057797}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF381205; AHB63926.1; -; Genomic_RNA. DR GO; GO:0019012; C:virion; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR011492; DEAD_Flavivir. DR InterPro; IPR001850; Flavivirus_NS3_S7. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR009003; Peptidase_S1_PA. DR Pfam; PF07652; Flavi_DEAD; 1. DR Pfam; PF00949; Peptidase_S7; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS51528; FLAVIVIRUS_NS3PRO; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|SAAS:SAAS00445701}; KW Helicase {ECO:0000256|SAAS:SAAS00445774}; KW Hydrolase {ECO:0000256|SAAS:SAAS00445903}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00445889}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00445834}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00445990}; KW Transferase {ECO:0000256|SAAS:SAAS00445745}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS00445806}; KW Virion {ECO:0000256|SAAS:SAAS00445868}. FT DOMAIN 1 178 Peptidase S7. {ECO:0000259|PROSITE: FT PS51528}. FT DOMAIN 180 336 Helicase ATP-binding. FT {ECO:0000259|PROSITE:PS51192}. FT DOMAIN 346 513 Helicase C-terminal. FT {ECO:0000259|PROSITE:PS51194}. FT NON_TER 1 1 {ECO:0000313|EMBL:AHB63926.1}. FT NON_TER 618 618 {ECO:0000313|EMBL:AHB63926.1}. SQ SEQUENCE 618 AA; 69247 MW; 70974FE11683A012 CRC64; AGVLSAVPSP PPVGKAELED GAYRIKQKGI LGYSQIGAGV YKEGTFHTMW HVTRGAVLMH KGKRIEPSWA DVRKDLISYG GGRKLEGEWK EGEEVQVLAL EPGKNPRAVQ TKPGLFKTNT GTIGAVSLDF SPGASGSPIV DKKGKVVGLY GNGVVTRSGT YVSAIAQTEK SIEDNPEIED DIFRKKRLTI MDLHPGAGKT KRYLPAIVRE AIKRGLRTLI LAPTRVVAAE MEEALRGLPI RYQTPAIRAE HTGREIVDLM CHATFTMRLL SPVRVPNYNL IIMDEAHFTD PASIAARGYI STRVEMGEAA GIFMTATPPG SRDPFPQSNA PIMDEEREIP ERSWNSGHEW VTDFKGKTVW FVPSIKAGND IAACLRKNGK KVIQLSRKTF DSEYIKTRTN DWDFVVTTDI SEMGANFKAE RVIDPRRCMK PVILTDGEER VILAGPMPVT HSSAAQRRGR IGRNPKNEND QYIYMGEPLE NDEDCAHWKE AKMLLDNINT PEGIIPSMFE PEREKVDAID GEYRLRGEAR KTFVDLMRRG DLPVWLAYRV AAEGINYADR RWCFDGIKNN QILEENVEVE IWTKEGERKK LKPRWLDARI YSDPLALKEF KEFAAGRK //