ID   V5N318_9PRIM            Unreviewed;       347 AA.
AC   V5N318;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   16-APR-2014, entry version 3.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=1.6.5.3;
GN   Name=ND2;
OS   Homo heidelbergensis (Heidelberg man).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=1425170;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Femur VIII; TISSUE=Bone;
RX   PubMed=24305051;
RA   Meyer M., Fu Q., Aximu-Petri A., Glocke I., Nickel B., Arsuaga J.L.,
RA   Martinez I., Gracia A., de Castro J.M., Carbonell E., Paabo S.;
RT   "A mitochondrial genome sequence of a hominin from Sima de los
RT   Huesos.";
RL   Nature 505:403-406(2014).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC       ubiquinol + 4 H(+)(Out).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family.
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DR   EMBL; KF683087; AHA82094.1; -; Genomic_DNA.
DR   RefSeq; YP_008963988.1; NC_023100.1.
DR   GeneID; 17961566; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR001750; NADH_UbQ/plastoQ_OxRdtase.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Oxidored_q1; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport; Ubiquinone.
SQ   SEQUENCE   347 AA;  38887 MW;  5C9A30A2742F700C CRC64;
     MNPLAQPXXX STIFTGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP RSTEAAIKYF
     LTQATASMIL LMAILFNNML SGQWTMTNTX XXXXSLMIMM AMAMKLGMAP FHFWVPEVTQ
     GTPLTSGLLL LTWQKLAPIS IMYQISPSLN VSLLLTLSIL SIMAGSWGGL NQTQLRKILA
     YSSITHMGWM MAVLPYNPNM TILNLTIYIX LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL
     TPLIPSTLLS LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST
     SITLLPMSNN VKMKWQFEHT KPTPFLPTLI ALTTLLLPIS PFMLXXX
//