ID   V4KDB3_EUTSA            Unreviewed;       712 AA.
AC   V4KDB3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-FEB-2025, entry version 37.
DE   RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU000672};
DE            EC=1.4.3.- {ECO:0000256|RuleBase:RU000672};
GN   ORFNames=EUTSA_v10023306mg {ECO:0000313|EMBL:ESQ29104.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ29104.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ29104.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000672};
CC       Note=Contains 1 topaquinone per subunit.
CC       {ECO:0000256|RuleBase:RU000672};
CC   -!- PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of
CC       a specific tyrosyl residue. {ECO:0000256|PIRSR:PIRSR600269-51,
CC       ECO:0000256|RuleBase:RU000672}.
CC   -!- SIMILARITY: Belongs to the copper/topaquinone oxidase family.
CC       {ECO:0000256|ARBA:ARBA00007983, ECO:0000256|RuleBase:RU000672}.
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DR   EMBL; KI517881; ESQ29104.1; -; Genomic_DNA.
DR   RefSeq; XP_006391818.1; XM_006391756.1.
DR   AlphaFoldDB; V4KDB3; -.
DR   STRING; 72664.V4KDB3; -.
DR   EnsemblPlants; ESQ29104; ESQ29104; EUTSA_v10023306mg.
DR   GeneID; 18010301; -.
DR   Gramene; ESQ29104; ESQ29104; EUTSA_v10023306mg.
DR   KEGG; eus:EUTSA_v10023306mg; -.
DR   eggNOG; KOG1186; Eukaryota.
DR   OMA; RVIRVQC; -.
DR   OrthoDB; 5379943at2759; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:EnsemblPlants.
DR   GO; GO:0052595; F:aliphatic amine oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0008131; F:primary methylamine oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:EnsemblPlants.
DR   GO; GO:0009308; P:amine metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006809; P:nitric oxide biosynthetic process; IEA:EnsemblPlants.
DR   GO; GO:0009733; P:response to auxin; IEA:EnsemblPlants.
DR   GO; GO:0009753; P:response to jasmonic acid; IEA:EnsemblPlants.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; IEA:EnsemblPlants.
DR   GO; GO:1904585; P:response to putrescine; IEA:EnsemblPlants.
DR   GO; GO:0009751; P:response to salicylic acid; IEA:EnsemblPlants.
DR   GO; GO:0009414; P:response to water deprivation; IEA:EnsemblPlants.
DR   GO; GO:0009611; P:response to wounding; IEA:EnsemblPlants.
DR   FunFam; 2.70.98.20:FF:000004; Amine oxidase; 1.
DR   Gene3D; 3.10.450.40; -; 2.
DR   Gene3D; 2.70.98.20; Copper amine oxidase, catalytic domain; 1.
DR   InterPro; IPR049947; Cu_Am_Ox_Cu-bd.
DR   InterPro; IPR000269; Cu_amine_oxidase.
DR   InterPro; IPR015798; Cu_amine_oxidase_C.
DR   InterPro; IPR036460; Cu_amine_oxidase_C_sf.
DR   InterPro; IPR016182; Cu_amine_oxidase_N-reg.
DR   InterPro; IPR015800; Cu_amine_oxidase_N2.
DR   InterPro; IPR015802; Cu_amine_oxidase_N3.
DR   PANTHER; PTHR10638:SF69; AMINE OXIDASE [COPPER-CONTAINING] GAMMA 1-RELATED; 1.
DR   PANTHER; PTHR10638; COPPER AMINE OXIDASE; 1.
DR   Pfam; PF01179; Cu_amine_oxid; 1.
DR   Pfam; PF02727; Cu_amine_oxidN2; 1.
DR   Pfam; PF02728; Cu_amine_oxidN3; 1.
DR   SUPFAM; SSF49998; Amine oxidase catalytic domain; 1.
DR   SUPFAM; SSF54416; Amine oxidase N-terminal region; 2.
DR   PROSITE; PS01165; COPPER_AMINE_OXID_2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008, ECO:0000256|RuleBase:RU000672};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000672};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU000672};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW   TPQ {ECO:0000256|ARBA:ARBA00022772, ECO:0000256|PIRSR:PIRSR600269-50}.
FT   DOMAIN          60..142
FT                   /note="Copper amine oxidase N2-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02727"
FT   DOMAIN          152..246
FT                   /note="Copper amine oxidase N3-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02728"
FT   DOMAIN          275..692
FT                   /note="Copper amine oxidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01179"
FT   ACT_SITE        354
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600269-50"
FT   ACT_SITE        442
FT                   /note="Schiff-base intermediate with substrate; via
FT                   topaquinone"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600269-50"
FT   MOD_RES         442
FT                   /note="2',4',5'-topaquinone"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600269-51"
SQ   SEQUENCE   712 AA;  79856 MW;  6B6101D3C10B67AA CRC64;
     MAQPSFARLS LLFFGFLLLF ATYSWVFGPD SGFLSGTRVR KTLGSDPKLR VDHSSDKPHH
     PLDPLTVREI ERVRSILSGH DPDFRSGSAT IHSMALDEPD KARVVRWKKG NRLPSRRAEV
     VALSGGKSHV ITVDLESGRV VSDLINPSSG YPILTMDDLI AASQVPFKSI EFNRSIEARG
     VKFSDLVCIT PFAGWFGPEE EGRRIIRVQC YTSKDTPNYF MRPLEGLYAM VDMNKLEVIK
     VVDKGPVPIP KAAGTEYRYS VLNKPVHMDP INPISMEQPG GPSFRVEGGH LVKWANWVFH
     VKADQRAGMI ISQATVRDSE TGEPRSVMYK GFPSELFVPY MDPEELWYYK TYMDAGELGL
     GPPAMPLVPL NDCPRNAYYI DGIFASPDGK AIVQPNMICL FERYAGDVSW RHSEILIPNV
     DIKEARPKVT LVARMATSVG NYDYIVDWEF QTDGLIRVTV AASGMLMVKG TPYENVDDLG
     DKEDDSGPLI SENVIGVVHD HFITFHLDMD IDGHTNNSLV KFHLEKQRIP TGKSPRKSYL
     KVKKYVAKTE KDAQIKLNLY DPYEFHIVNP NRKSRIGNPA GYKIVPGGNA ASLLDHDDPP
     QIRGAFTNNQ IWVTQYNRSE QFAGGVLVYQ SHGDDTLQVW SDRDRSIENK DIVLWYTLGF
     HHVPCQEDYP VMPTVAASFE LKPANFFETN PILGVAPFLE KDLPVCRPFA SS
//