ID   V4KDB3_EUTSA            Unreviewed;       712 AA.
AC   V4KDB3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU000672};
DE            EC=1.4.3.- {ECO:0000256|RuleBase:RU000672};
GN   ORFNames=EUTSA_v10023306mg {ECO:0000313|EMBL:ESQ29104.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae;
OC   Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ29104.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ29104.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J.,
RA   Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- COFACTOR:
CC       Name=L-topaquinone; Xref=ChEBI:CHEBI:79027;
CC         Evidence={ECO:0000256|RuleBase:RU000672};
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000672};
CC       Note=Contains 1 topaquinone per subunit.
CC       {ECO:0000256|RuleBase:RU000672};
CC   -!- COFACTOR:
CC       Name=L-topaquinone; Xref=ChEBI:CHEBI:79027;
CC         Evidence={ECO:0000256|PIRSR:PIRSR600269-51};
CC       Note=Contains 1 topaquinone per subunit.
CC       {ECO:0000256|PIRSR:PIRSR600269-51};
CC   -!- PTM: Topaquinone (TPQ) is generated by copper-dependent
CC       autoxidation of a specific tyrosyl residue.
CC       {ECO:0000256|PIRSR:PIRSR600269-51, ECO:0000256|RuleBase:RU000672}.
CC   -!- SIMILARITY: Belongs to the copper/topaquinone oxidase family.
CC       {ECO:0000256|RuleBase:RU000672}.
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DR   EMBL; KI517881; ESQ29104.1; -; Genomic_DNA.
DR   RefSeq; XP_006391818.1; XM_006391756.1.
DR   GeneID; 18010301; -.
DR   KEGG; eus:EUTSA_v10023306mg; -.
DR   KO; K00276; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0008131; F:primary amine oxidase activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0009308; P:amine metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.70.98.20; -; 1.
DR   InterPro; IPR000269; Cu_amine_oxidase.
DR   InterPro; IPR015798; Cu_amine_oxidase_C.
DR   InterPro; IPR036460; Cu_amine_oxidase_C_sf.
DR   InterPro; IPR016182; Cu_amine_oxidase_N-reg.
DR   InterPro; IPR015800; Cu_amine_oxidase_N2.
DR   InterPro; IPR015802; Cu_amine_oxidase_N3.
DR   PANTHER; PTHR10638; PTHR10638; 1.
DR   Pfam; PF01179; Cu_amine_oxid; 1.
DR   Pfam; PF02727; Cu_amine_oxidN2; 1.
DR   Pfam; PF02728; Cu_amine_oxidN3; 1.
DR   SUPFAM; SSF49998; SSF49998; 1.
DR   SUPFAM; SSF54416; SSF54416; 2.
DR   PROSITE; PS01165; COPPER_AMINE_OXID_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030689};
KW   Copper {ECO:0000256|RuleBase:RU000672};
KW   Metal-binding {ECO:0000256|RuleBase:RU000672};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000672};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW   TPQ {ECO:0000256|PIRSR:PIRSR600269-50, ECO:0000256|RuleBase:RU000672}.
FT   DOMAIN       60    142       Cu_amine_oxidN2. {ECO:0000259|Pfam:
FT                                PF02727}.
FT   DOMAIN      152    250       Cu_amine_oxidN3. {ECO:0000259|Pfam:
FT                                PF02728}.
FT   DOMAIN      275    696       Cu_amine_oxid. {ECO:0000259|Pfam:
FT                                PF01179}.
FT   ACT_SITE    354    354       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR600269-50}.
FT   ACT_SITE    442    442       Schiff-base intermediate with substrate;
FT                                via topaquinone. {ECO:0000256|PIRSR:
FT                                PIRSR600269-50}.
FT   MOD_RES     442    442       2',4',5'-topaquinone. {ECO:0000256|PIRSR:
FT                                PIRSR600269-51}.
SQ   SEQUENCE   712 AA;  79856 MW;  6B6101D3C10B67AA CRC64;
     MAQPSFARLS LLFFGFLLLF ATYSWVFGPD SGFLSGTRVR KTLGSDPKLR VDHSSDKPHH
     PLDPLTVREI ERVRSILSGH DPDFRSGSAT IHSMALDEPD KARVVRWKKG NRLPSRRAEV
     VALSGGKSHV ITVDLESGRV VSDLINPSSG YPILTMDDLI AASQVPFKSI EFNRSIEARG
     VKFSDLVCIT PFAGWFGPEE EGRRIIRVQC YTSKDTPNYF MRPLEGLYAM VDMNKLEVIK
     VVDKGPVPIP KAAGTEYRYS VLNKPVHMDP INPISMEQPG GPSFRVEGGH LVKWANWVFH
     VKADQRAGMI ISQATVRDSE TGEPRSVMYK GFPSELFVPY MDPEELWYYK TYMDAGELGL
     GPPAMPLVPL NDCPRNAYYI DGIFASPDGK AIVQPNMICL FERYAGDVSW RHSEILIPNV
     DIKEARPKVT LVARMATSVG NYDYIVDWEF QTDGLIRVTV AASGMLMVKG TPYENVDDLG
     DKEDDSGPLI SENVIGVVHD HFITFHLDMD IDGHTNNSLV KFHLEKQRIP TGKSPRKSYL
     KVKKYVAKTE KDAQIKLNLY DPYEFHIVNP NRKSRIGNPA GYKIVPGGNA ASLLDHDDPP
     QIRGAFTNNQ IWVTQYNRSE QFAGGVLVYQ SHGDDTLQVW SDRDRSIENK DIVLWYTLGF
     HHVPCQEDYP VMPTVAASFE LKPANFFETN PILGVAPFLE KDLPVCRPFA SS
//