ID   U6C5E1_HEV              Unreviewed;       137 AA.
AC   U6C5E1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   12-AUG-2020, entry version 18.
DE   RecName: Full=Protein ORF2 {ECO:0000256|ARBA:ARBA00021182, ECO:0000256|RuleBase:RU363023};
DE   Flags: Fragment;
OS   Hepatitis E virus (HEV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Hepelivirales; Hepeviridae; Orthohepevirus; Orthohepevirus A.
OX   NCBI_TaxID=12461 {ECO:0000313|EMBL:BAO04103.1};
OH   NCBI_TaxID=69079; Bandicota bengalensis (lesser bandicoot rat).
OH   NCBI_TaxID=9481; Callithrix.
OH   NCBI_TaxID=9536; Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey).
OH   NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9539; Macaca (macaques).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
OH   NCBI_TaxID=9520; Saimiri (squirrel monkeys).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1] {ECO:0000313|EMBL:BAO04103.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SwJLMie220_ORF2 {ECO:0000313|EMBL:BAO04103.1};
RA   Okano H., Takahashi M., Isono Y., Tanaka H., Nakano T., Oya Y.,
RA   Sugimoto K., Ito K., Ohmori S., Maegawa T., Kobayashi M., Nagashima S.,
RA   Nishizawa T., Okamoto H.;
RT   "Characterization of sporadic acute hepatitis E and comparison of hepatitis
RT   E virus genomes in acute hepatitis patients and pig liver sold as food in
RT   Mie, Japan.";
RL   Hepatol. Res. 0:0-0(2013).
CC   -!- FUNCTION: Major viral capsid protein that encapsidates the viral
CC       genome. Binds to the 5' end of the genomic RNA.
CC       {ECO:0000256|RuleBase:RU363023}.
CC   -!- SUBUNIT: Self-assembles to form the capsid.
CC       {ECO:0000256|RuleBase:RU363023}.
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host cell surface
CC       {ECO:0000256|ARBA:ARBA00004426, ECO:0000256|RuleBase:RU363023}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192,
CC       ECO:0000256|RuleBase:RU363023}. Virion {ECO:0000256|ARBA:ARBA00004328,
CC       ECO:0000256|RuleBase:RU363023}.
CC   -!- SIMILARITY: Belongs to the hepevirus capsid protein family.
CC       {ECO:0000256|ARBA:ARBA00008877, ECO:0000256|RuleBase:RU363023}.
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DR   EMBL; AB824711; BAO04103.1; -; Genomic_RNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004261; SP2.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03014; SP2; 1.
PE   3: Inferred from homology;
KW   Capsid protein {ECO:0000256|ARBA:ARBA00022561,
KW   ECO:0000256|RuleBase:RU363023};
KW   Host cytoplasm {ECO:0000256|RuleBase:RU363023};
KW   RNA-binding {ECO:0000256|RuleBase:RU363023};
KW   Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|RuleBase:RU363023}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAO04103.1"
FT   NON_TER         137
FT                   /evidence="ECO:0000313|EMBL:BAO04103.1"
SQ   SEQUENCE   137 AA;  14580 MW;  ED40CEB524D15502 CRC64;
     AEEEATSGLV MLCIHGSPVN SYTNTPYTGA LGLLDFALEL EFRNLTPGNT NTRVSRYTST
     ARHRLRRGAD GTAELTTTAA TRFMKDLHFT GTNGVGEVGR GIALTLFNLA DTLLGGLPTE
     LISSAGGQLF YSRPVVS
//