ID U5ZAB9_HUMAN Unreviewed; 261 AA. AC U5ZAB9; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 01-OCT-2014, entry version 7. DE RecName: Full=Cytochrome c oxidase subunit 3 {ECO:0000256|RuleBase:RU003375}; GN Name=COX3 {ECO:0000313|EMBL:AHA02043.1}; OS Homo sapiens (Human). OG Mitochondrion {ECO:0000313|EMBL:AHA02043.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AHA02043.1}; RN [1] {ECO:0000313|EMBL:AHA02043.1} RP NUCLEOTIDE SEQUENCE. RA Duggan A.T., Whitten M., Wiebe V., Crawford M., Butthof A., RA Spitsyn V., Makarov S., Novgorodov I., Osakovsky V., Pakendorf B.; RT "Investigating the Prehistory of Tungusic Peoples of Siberia and the RT Amur-Ussuri Region with Complete mtDNA Genome Sequences and Y- RT chromosomal Markers."; RL PLoS ONE 8:e83570-e83570(2013). CC -!- FUNCTION: Subunits I, II and III form the functional core of the CC enzyme complex. {ECO:0000256|RuleBase:RU003375}. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC {ECO:0000256|RuleBase:RU003375}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF148554; AHA02043.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR InterPro; IPR000298; Cyt_c_oxidase_su3_dom. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane; KW Mitochondrion {ECO:0000256|RuleBase:RU003375, KW ECO:0000313|EMBL:AHA02043.1}; KW Transmembrane {ECO:0000256|RuleBase:RU003375}. SQ SEQUENCE 261 AA; 29921 MW; A0438335DE21D914 CRC64; MTHQSHAYHM VKPSPWPLAG ALSALLMTSG LAMWFHFHSM TLLMLGLLTN TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL FLYVSIYWWG S //