ID U5ZAB9_HUMAN Unreviewed; 261 AA. AC U5ZAB9; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 11-DEC-2019, entry version 22. DE RecName: Full=Cytochrome c oxidase subunit 3 {ECO:0000256|RuleBase:RU003375}; GN Name=COX3 {ECO:0000313|EMBL:AHA02043.1}; OS Homo sapiens (Human). OG Mitochondrion {ECO:0000313|EMBL:AHA02043.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AHA02043.1}; RN [1] {ECO:0000313|EMBL:AHA02043.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24349531; DOI=10.1371/journal.pone.0083570; RA Duggan A.T., Whitten M., Wiebe V., Crawford M., Butthof A., Spitsyn V., RA Makarov S., Novgorodov I., Osakovsky V., Pakendorf B.; RT "Investigating the Prehistory of Tungusic Peoples of Siberia and the Amur- RT Ussuri Region with Complete mtDNA Genome Sequences and Y-chromosomal RT Markers."; RL PLoS ONE 8:e83570-e83570(2013). CC -!- FUNCTION: Subunits I, II and III form the functional core of the enzyme CC complex. {ECO:0000256|RuleBase:RU003375}. CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family. CC {ECO:0000256|RuleBase:RU003375, ECO:0000256|SAAS:SAAS00709834}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF148554; AHA02043.1; -; Genomic_DNA. DR eggNOG; KOG4664; Eukaryota. DR eggNOG; COG1845; LUCA. DR ChiTaRS; COX3; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro. DR CDD; cd01665; Cyt_c_Oxidase_III; 1. DR Gene3D; 1.20.120.80; -; 1. DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3. DR InterPro; IPR033945; Cyt_c_oxase_su3_dom. DR InterPro; IPR000298; Cyt_c_oxidase-like_su3. DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf. DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx. DR PANTHER; PTHR11403; PTHR11403; 1. DR Pfam; PF00510; COX3; 1. DR SUPFAM; SSF81452; SSF81452; 1. DR PROSITE; PS50253; COX3; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAAS:SAAS00709742, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003375, ECO:0000313|EMBL:AHA02043.1}; KW Transmembrane {ECO:0000256|RuleBase:RU003375, KW ECO:0000256|SAAS:SAAS00709762, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00709799, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 16..35 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 41..58 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 79..102 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 159..177 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 197..220 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 240..260 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 4..261 FT /note="COX3" FT /evidence="ECO:0000259|PROSITE:PS50253" SQ SEQUENCE 261 AA; 29921 MW; A0438335DE21D914 CRC64; MTHQSHAYHM VKPSPWPLAG ALSALLMTSG LAMWFHFHSM TLLMLGLLTN TLTMYQWWRD VTRESTYQGH HTPPVQKGLR YGMILFITSE VFFFAGFFWA FYHSSLAPTP QLGGHWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS LMENNRNQMI QALLITILLG LYFTLLQASE YFESPFTISD GIYGSTFFVA TGFHGLHVII GSTFLTICFI RQLMFHFTSK HHFGFEAAAW YWHFVDVVWL FLYVSIYWWG S //