ID U5RYW0_9CLOT Unreviewed; 725 AA. AC U5RYW0; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 08-NOV-2023, entry version 47. DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:AGY77885.1}; DE EC=2.7.7.65 {ECO:0000313|EMBL:AGY77885.1}; GN ORFNames=CAETHG_3682 {ECO:0000313|EMBL:AGY77885.1}; OS Clostridium autoethanogenum DSM 10061. OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; OC Clostridium. OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY77885.1, ECO:0000313|Proteomes:UP000017590}; RN [1] {ECO:0000313|EMBL:AGY77885.1, ECO:0000313|Proteomes:UP000017590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY77885.1}; RX PubMed=24655715; DOI=10.1186/1754-6834-7-40; RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S., RA Mitchell W., Land M.L., Dassanayake A., Kopke M.; RT "Comparison of single-molecule sequencing and hybrid approaches for RT finishing the genome of Clostridium autoethanogenum and analysis of CRISPR RT systems in industrial relevant Clostridia."; RL Biotechnol. Biofuels 7:40-40(2014). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP006763; AGY77885.1; -; Genomic_DNA. DR RefSeq; WP_023163324.1; NZ_CP012395.1. DR AlphaFoldDB; U5RYW0; -. DR EnsemblBacteria; AGY77885; AGY77885; CAETHG_3682. DR KEGG; cah:CAETHG_3682; -. DR PATRIC; fig|1341692.11.peg.3699; -. DR HOGENOM; CLU_000445_92_5_9; -. DR Proteomes; UP000017590; Chromosome. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd01949; GGDEF; 1. DR CDD; cd00077; HDc; 1. DR CDD; cd00130; PAS; 2. DR Gene3D; 3.30.70.270; -; 1. DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1. DR Gene3D; 3.30.450.20; PAS domain; 2. DR InterPro; IPR000160; GGDEF_dom. DR InterPro; IPR003607; HD/PDEase_dom. DR InterPro; IPR037522; HD_GYP_dom. DR InterPro; IPR029787; Nucleotide_cyclase. DR InterPro; IPR000014; PAS. DR InterPro; IPR035965; PAS-like_dom_sf. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR NCBIfam; TIGR00254; GGDEF; 1. DR NCBIfam; TIGR00229; sensory_box; 2. DR PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1. DR PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1. DR Pfam; PF00990; GGDEF; 1. DR Pfam; PF13487; HD_5; 1. DR Pfam; PF13426; PAS_9; 2. DR SMART; SM00267; GGDEF; 1. DR SMART; SM00471; HDc; 1. DR SMART; SM00091; PAS; 2. DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1. DR SUPFAM; SSF55073; Nucleotide cyclase; 1. DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2. DR PROSITE; PS50887; GGDEF; 1. DR PROSITE; PS51832; HD_GYP; 1. DR PROSITE; PS50112; PAS; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotidyltransferase {ECO:0000313|EMBL:AGY77885.1}; KW Transferase {ECO:0000313|EMBL:AGY77885.1}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 20..41 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 61..79 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 138..208 FT /note="PAS" FT /evidence="ECO:0000259|PROSITE:PS50112" FT DOMAIN 415..545 FT /note="GGDEF" FT /evidence="ECO:0000259|PROSITE:PS50887" FT DOMAIN 536..725 FT /note="HD-GYP" FT /evidence="ECO:0000259|PROSITE:PS51832" SQ SEQUENCE 725 AA; 84019 MW; D0E7CFD204AE129D CRC64; MLVSIRKKIY SIFNKNNKPW KYESIRICLI FLGISLPWVY FSDRIAIKFA GNDSMFLAIS TYKGCLYVAV TSFVLYLLIS NILKKVALVE EKLNESYKEL SLVNEELKSY VKKLIDSKKK LGLQYDEIIK SEKKLSKSEE KSRAIIKALP DTLFVVNDKG YLIDCMSSDE KYVLMPKKDF IGKNILEIFP KGMSEKLYEK MQVVLKEGIL DSFEYKVWIH NKEHHFEIRM VKNNEKEILA ISRNVTDERQ NEMELKLSEA TFRNLFENSS DAIFIISDGK IVDCNLAMIK ALGYDSKTFI LGKNPLEFYP EKQPDGEITR EKVIRMRKNT IEKGKCKFEW WYKKADGNVL PVEVMLTTIF LNGKKVFHSL WRDIRDRKEM ELKLEYLSYR DQLTGLYNRR FFEAELNRLD VERSLPLTIV MGDVNGLKLV NDSLGHVMGD KLLKKVAEVI KKGCRKEDIV ARWGGDEFVI LLPKTDAFQT EQILKRIKSI AAKEKIGAID ISISFGYETR KSREVKIQET FKKAEDYMYK KKLFEGPNMI GKTISAIITA LHEKNKREEE HSHRVSILCE DMGEALGLLE HEIRELKTVG LLHDIGKVAI EEHLLNKPGK LTDEEWQEIK RHPEIGYRIL NTVDDMSEMA YYVLAHHERW DGKGYPKGLK EKEIPLQSRI IAIADSYDAM TSERSYRSAL PEEVAIGELK LNAGTQFDPE LIGVFIEKVL DKLHC //