ID U5RW46_9CLOT Unreviewed; 238 AA. AC U5RW46; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 03-MAY-2023, entry version 45. DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU003887}; DE EC=5.4.99.- {ECO:0000256|RuleBase:RU003887}; GN ORFNames=CAETHG_1561 {ECO:0000313|EMBL:AGY75784.1}; OS Clostridium autoethanogenum DSM 10061. OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae; OC Clostridium. OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY75784.1, ECO:0000313|Proteomes:UP000017590}; RN [1] {ECO:0000313|EMBL:AGY75784.1, ECO:0000313|Proteomes:UP000017590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY75784.1}; RX PubMed=24655715; DOI=10.1186/1754-6834-7-40; RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S., RA Mitchell W., Land M.L., Dassanayake A., Kopke M.; RT "Comparison of single-molecule sequencing and hybrid approaches for RT finishing the genome of Clostridium autoethanogenum and analysis of CRISPR RT systems in industrial relevant Clostridia."; RL Biotechnol. Biofuels 7:40-40(2014). CC -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family. CC {ECO:0000256|ARBA:ARBA00008348, ECO:0000256|RuleBase:RU003887}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP006763; AGY75784.1; -; Genomic_DNA. DR RefSeq; WP_023162298.1; NZ_CP012395.1. DR AlphaFoldDB; U5RW46; -. DR EnsemblBacteria; AGY75784; AGY75784; CAETHG_1561. DR KEGG; cah:CAETHG_1561; -. DR PATRIC; fig|1341692.11.peg.1576; -. DR HOGENOM; CLU_024979_1_2_9; -. DR Proteomes; UP000017590; Chromosome. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt. DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt. DR CDD; cd02553; PseudoU_synth_RsuA; 1. DR CDD; cd00165; S4; 1. DR Gene3D; 3.30.70.1560; Alpha-L RNA-binding motif; 1. DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1. DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1. DR InterPro; IPR042092; PsdUridine_s_RsuA/RluB/E/F_cat. DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf. DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA. DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F. DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS. DR InterPro; IPR002942; S4_RNA-bd. DR InterPro; IPR036986; S4_RNA-bd_sf. DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N. DR PANTHER; PTHR47683:SF4; PSEUDOURIDINE SYNTHASE; 1. DR PANTHER; PTHR47683; PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED; 1. DR Pfam; PF00849; PseudoU_synth_2; 1. DR Pfam; PF01479; S4; 1. DR SMART; SM00363; S4; 1. DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1. DR SUPFAM; SSF55120; Pseudouridine synthase; 1. DR TIGRFAMs; TIGR00093; pseudouridine synthase; 1. DR PROSITE; PS01149; PSI_RSU; 1. DR PROSITE; PS50889; S4; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003887}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}. FT DOMAIN 2..62 FT /note="RNA-binding S4" FT /evidence="ECO:0000259|SMART:SM00363" SQ SEQUENCE 238 AA; 27206 MW; 1D4857A05728C503 CRC64; MDRIDKILAN LGFGTRKEIK AVVKNGEVKI NGTVIKDSSM KIDPDKSTIE VGGNVVEYKK NIYLLMNKPQ GVVSATFDNY DETVIDILEP EYQAFKPFPV GRLDKDTEGL LLITNDGELN HRMISPKNHV DKVYYAEIDK YLDERDVNRF KKGIQLKDGY KCLPGKLHII ESDEDGAKVE VTIQEGKFHQ VKRMFNALGK NVVYLKRIKF GPIDLDKDLN LGQYRELSKN EIESIKRI //