ID U5RW46_9CLOT Unreviewed; 238 AA. AC U5RW46; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 16-MAR-2016, entry version 17. DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU003887}; DE EC=5.4.99.- {ECO:0000256|RuleBase:RU003887}; GN ORFNames=CAETHG_1561 {ECO:0000313|EMBL:AGY75784.1}, CLAU_1520 GN {ECO:0000313|EMBL:ALU35949.1}; OS Clostridium autoethanogenum DSM 10061. OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; OC Clostridium. OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY75784.1, ECO:0000313|Proteomes:UP000017590}; RN [1] {ECO:0000313|EMBL:AGY75784.1, ECO:0000313|Proteomes:UP000017590} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY75784.1}; RX PubMed=24655715; DOI=10.1186/1754-6834-7-40; RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S., RA Mitchell W., Land M.L., Dassanayake A., Kopke M.; RT "Comparison of single-molecule sequencing and hybrid approaches for RT finishing the genome of Clostridium autoethanogenum and analysis of RT CRISPR systems in industrial relevant Clostridia."; RL Biotechnol. Biofuels 7:40-40(2014). RN [2] {ECO:0000313|EMBL:ALU35949.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DSM 10061 {ECO:0000313|EMBL:ALU35949.1}; RX PubMed=26692227; DOI=10.1186/s12864-015-2287-5; RA Humphreys C.M., McLean S., Schatschneider S., Millat T., Henstra A.M., RA Annan F.J., Breitkopf R., Pander B., Piatek P., Rowe P., RA Wichlacz A.T., Woods C., Norman R., Blom J., Goesman A., Hodgman C., RA Barrett D., Thomas N.R., Winzer K., Minton N.P.; RT "Whole genome sequence and manual annotation of Clostridium RT autoethanogenum, an industrially relevant bacterium."; RL BMC Genomics 16:1085-1085(2015). CC -!- SIMILARITY: Belongs to the pseudouridine synthase rsuA family. CC {ECO:0000256|RuleBase:RU003887}. CC -!- SIMILARITY: Contains S4 RNA-binding domain. CC {ECO:0000256|SAAS:SAAS00082987}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP006763; AGY75784.1; -; Genomic_DNA. DR EMBL; CP012395; ALU35949.1; -; Genomic_DNA. DR RefSeq; WP_023162298.1; NZ_CP012395.1. DR EnsemblBacteria; AGY75784; AGY75784; CAETHG_1561. DR KEGG; cah:CAETHG_1561; -. DR KO; K06183; -. DR Proteomes; UP000017590; Chromosome. DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro. DR Gene3D; 3.10.290.10; -; 1. DR InterPro; IPR020103; PsdUridine_synth_cat_dom. DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F. DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS. DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD. DR InterPro; IPR002942; S4_RNA-bd. DR Pfam; PF00849; PseudoU_synth_2; 1. DR Pfam; PF01479; S4; 1. DR SMART; SM00363; S4; 1. DR SUPFAM; SSF55120; SSF55120; 1. DR TIGRFAMs; TIGR00093; TIGR00093; 1. DR PROSITE; PS01149; PSI_RSU; 1. DR PROSITE; PS50889; S4; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000017590}; KW Isomerase {ECO:0000256|RuleBase:RU003887, KW ECO:0000256|SAAS:SAAS00429931}; KW Reference proteome {ECO:0000313|Proteomes:UP000017590}; KW RNA-binding {ECO:0000256|SAAS:SAAS00458081}. FT DOMAIN 2 67 S4 RNA-binding. {ECO:0000259|PROSITE: FT PS50889}. SQ SEQUENCE 238 AA; 27206 MW; 1D4857A05728C503 CRC64; MDRIDKILAN LGFGTRKEIK AVVKNGEVKI NGTVIKDSSM KIDPDKSTIE VGGNVVEYKK NIYLLMNKPQ GVVSATFDNY DETVIDILEP EYQAFKPFPV GRLDKDTEGL LLITNDGELN HRMISPKNHV DKVYYAEIDK YLDERDVNRF KKGIQLKDGY KCLPGKLHII ESDEDGAKVE VTIQEGKFHQ VKRMFNALGK NVVYLKRIKF GPIDLDKDLN LGQYRELSKN EIESIKRI //