ID U5NGV5_MARFC Unreviewed; 199 AA. AC U5NGV5; DT 22-JAN-2014, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 1. DT 19-MAR-2014, entry version 3. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Margaritifera falcata (Western pearlshell) (Alasmodon falcata). OG Mitochondrion. OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; OC Palaeoheterodonta; Unionoida; Unionoidea; Margaritiferidae; OC Margaritifera. OX NCBI_TaxID=52361; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=24118560; DOI=10.1111/mec.12557; RA Mock K.E., Brim Box J.C., Chong J.P., Furnish J., Howard J.K.; RT "Comparison of population genetic patterns in two widespread RT freshwater mussels with contrasting life histories in western North RT America."; RL Mol. Ecol. 22:6060-6073(2013). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF701438; AGY30061.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:1902600; P:hydrogen ion transmembrane transport; IEA:GOC. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR000883; Cyt_c_Oxase_su1. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 199 199 SQ SEQUENCE 199 AA; 21087 MW; 8E6597B00C544649 CRC64; ALWSGLIGLA LSLLIRAELG QPGSLLGDDQ LYNVIVTAHA FMMIFFLVMP MMIGGFGNWL IPLMIGAPDM AFPRLNNLSF WLLVPALFLL LSSSLVESGV GTGWTVYPPL SSNVSHSGAS VDLAIFSLHL AGASSILGAI NFISTVGNMR SPGVVAERIP LFVWAVTVTA ILLVAALPVL AGAITMLLTD RNLNTSFFD //