ID U3N5L9_9FLAV Unreviewed; 174 AA. AC U3N5L9; DT 11-DEC-2013, integrated into UniProtKB/TrEMBL. DT 11-DEC-2013, sequence version 1. DT 08-NOV-2023, entry version 28. DE SubName: Full=Envelope protein {ECO:0000313|EMBL:AGW23570.1}; DE Flags: Fragment; OS dengue virus type 3. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; OC Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus denguei; OC Dengue virus. OX NCBI_TaxID=11069 {ECO:0000313|EMBL:AGW23570.1}; RN [1] {ECO:0000313|EMBL:AGW23570.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MS11007292 {ECO:0000313|EMBL:AGW23570.1}; RA Chew M.H., Rahman M.M.; RT "Molecular epidemiology of dengue virus 3 and 4 isolated in Kuala Lumpur, RT Malaysia during 2011-2012."; RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Host endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004153}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Virion membrane CC {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004385}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KF144594; AGW23570.1; -; Genomic_RNA. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1. DR Gene3D; 3.30.67.10; Viral Envelope Glycoprotein, domain 2; 1. DR Gene3D; 3.30.387.10; Viral Envelope Glycoprotein, domain 3; 1. DR InterPro; IPR013755; Flav_gly_cen_dom_subdom1. DR InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer. DR InterPro; IPR036253; Glycoprot_cen/dimer_sf. DR InterPro; IPR038055; Glycoprot_E_dimer_dom. DR InterPro; IPR013756; GlyE_cen_dom_subdom2. DR Pfam; PF00869; Flavi_glycoprot; 1. DR SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1. PE 4: Predicted; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022804}; KW Membrane {ECO:0000256|ARBA:ARBA00022989}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879, KW ECO:0000313|EMBL:AGW23570.1}; KW Virion {ECO:0000256|ARBA:ARBA00022879, ECO:0000313|EMBL:AGW23570.1}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}. FT DOMAIN 2..157 FT /note="Envelope glycoprotein E central and dimerisation" FT /evidence="ECO:0000259|Pfam:PF00869" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AGW23570.1" FT NON_TER 174 FT /evidence="ECO:0000313|EMBL:AGW23570.1" SQ SEQUENCE 174 AA; 19181 MW; 08084A214998396E CRC64; TVIITVHTGD QHQVGNETQG VTAEITPQAS TTEAILPEYG TLGLECSPRT GLDFNEMILL TMKNKAWMVH RQWFFDLPLP WASGATTETP TWNRKELLVT FKNAHAKKQE VVVLGSQEGA MHTALTGATE IQNSGGTSIF AGHLKCRLKM DKLELKGMSY AMCTNTFVLK KEVS //