ID U3ISA8_ANAPP Unreviewed; 2241 AA. AC U3ISA8; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 2. DT 29-SEP-2021, entry version 45. DE SubName: Full=Pre-mRNA processing factor 8 {ECO:0000313|Ensembl:ENSAPLP00000010131}; GN Name=PRPF8 {ECO:0000313|Ensembl:ENSAPLP00000010131}; OS Anas platyrhynchos platyrhynchos (Northern mallard). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; OC Anatinae; Anas. OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000010131, ECO:0000313|Proteomes:UP000016666}; RN [1] {ECO:0000313|Ensembl:ENSAPLP00000010131} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2013) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSAPLP00000010131, ECO:0000313|Proteomes:UP000016666} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.; RT "A new Pekin duck reference genome."; RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSAPLT00000010838; ENSAPLP00000010131; ENSAPLG00000010357. DR GeneTree; ENSGT00390000015210; -. DR HOGENOM; CLU_000380_3_0_1; -. DR OMA; WVDRSDN; -. DR Proteomes; UP000016666; Chromosome 20. DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:Ensembl. DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:Ensembl. DR GO; GO:0071005; C:U2-type precatalytic spliceosome; IEA:Ensembl. DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:Ensembl. DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro. DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl. DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro. DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro. DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro. DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:Ensembl. DR CDD; cd13838; RNase_H_like_Prp8_IV; 1. DR Gene3D; 1.20.80.40; -; 1. DR Gene3D; 3.30.420.230; -; 1. DR Gene3D; 3.30.43.40; -; 1. DR InterPro; IPR000555; JAMM/MPN+_dom. DR InterPro; IPR037518; MPN. DR InterPro; IPR012591; PRO8NT. DR InterPro; IPR012592; PROCN. DR InterPro; IPR012984; PROCT. DR InterPro; IPR027652; PRP8. DR InterPro; IPR021983; PRP8_domainIV. DR InterPro; IPR043173; Prp8_domainIV_fingers. DR InterPro; IPR043172; Prp8_domainIV_palm. DR InterPro; IPR019581; Prp8_U5-snRNA-bd. DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf. DR InterPro; IPR019580; Prp8_U6-snRNA-bd. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR019582; RRM_spliceosomal_PrP8. DR PANTHER; PTHR11140; PTHR11140; 1. DR Pfam; PF01398; JAB; 1. DR Pfam; PF08082; PRO8NT; 1. DR Pfam; PF08083; PROCN; 1. DR Pfam; PF08084; PROCT; 1. DR Pfam; PF12134; PRP8_domainIV; 1. DR Pfam; PF10598; RRM_4; 1. DR Pfam; PF10597; U5_2-snRNA_bdg; 1. DR Pfam; PF10596; U6-snRNA_bdg; 1. DR SMART; SM00232; JAB_MPN; 1. DR SUPFAM; SSF53098; SSF53098; 2. DR PROSITE; PS50249; MPN; 1. PE 4: Predicted; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000016666}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}; KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}. FT DOMAIN 2009..2140 FT /note="MPN" FT /evidence="ECO:0000259|PROSITE:PS50249" SQ SEQUENCE 2241 AA; 262557 MW; BA2BE8B111B843CC CRC64; MPHAVLKLLE NMPMPWEQIR DVPVLYHITG AISFVNEIPW VIEPVYIAQW GSMWIMMRRE KRDRRHFKRM RFPPFDDEEP PLDYADNILD VEPLEAIQLE LDPEEDAPVL DWFYDHQPLK DNRKYVNGST YQRWQFTLPM MSTLYRLANQ LLTDLVDDNY FYLFDLKAFF TSKALNMAIP GGPKFEPLVR DINLQDEDWN EFNDINKIII RQPIRTEYKI AFPYLYNNLP HHVHLTWYHT PNVVFIKTED PDLPAFYFDP LINPISHRHS VKSQEPLPDD DEEFELPEFV EPFLKDTPLY TDNTANGIAL LWAPRPFNLR SGRTRRALDI PLVKNWYREH CPAGQPVKVR VSYQKLLKYY VLNALKHRPP KAQKKRYLFR SFKATKFFQS TKLDWVEVGL QVCRQGYNML NLLIHRKNLN YLHLDYNFNL KPVKTLTTKE RKKSRFGNAF HLCREVLRLT KLVVDSHVQY RLGNVDAFQL ADGLQYIFAH VGQLTGMYRY KYKLMRQIRM CKDLKHLIYY RFNTGPVGKG PGCGFWAPGW RVWLFFMRGI TPLLERWLGN LLARQFEGRH SKGVAKTVTK QRVESHFDLE LRAAVMHDIL DMMPEGIKQN KARTILQHLS EAWRCWKANI PWKVPGLPTP IENMILRYVK AKADWWTNTA HYNRERIRRG ATVDKTVCKK NLGRLTRLYL KAEQERQHNY LKDGPYITAE EAVAVYTTTV HWLESRRFSP IPFPPLSYKH DTKLLILALE RLKEAYSVKS RLNQSQREEL GLIEQAYDNP HEALSRIKRH LLTQRAFKEV GIEFMDLYSH LVPVYDVEPL EKITDAYLDQ YLWYEADKRR LFPPWIKPAD TEPPPLLVYK WCQGINNLQD VWETSEGECN VMLESRFEKM YEKIDLTLLN RLLRLIVDHN IADYMTAKNN VVINYKDMNH TNSYGIIRGL QFASFIVQYY GLVMDLLVLG LHRASEMAGP PQMPNDFLSF QDIATEVAHP IRLFCRYIDR IHIFFRFTAD EARDLIQRYL TEHPDPNNEN IVGYNNKKCW PRDARMRLMK HDVNLGRAVF WDIKNRLPRS VTTVQWENSF VSVYSKDNPN LLFNMCGFEC RILPKCRTSY EEFTHKDGVW NLQNEVTKER TAQCFLRVDD ESMQRFHNRV RQILMASGST TFTKIVNKWN TALIGLMTYF REAVVNTQEL LDLLVKCENK IQTRIKIGLN SKMPSRFPPV VFYTPKELGG LGMLSMGHVL IPQSDLRWSK QTDVGITHFR SGMSHEEDQL IPNLYRYIQP WESEFIDSQR VWAEYALKRQ EAIAQNRRLT LEDLEDSWDR GIPRINTLFQ KDRHTLAYDK GWRVRTDFKQ YQVLKQNPFW WTHQRHDGKL WNLNNYRTDM IQALGGVEGI LEHTLFKGTY FPTWEGLFWE KASGFEESMK WKKLTNAQRS GLNQIPNRRF TLWWSPTINR ANVYVGFQVQ LDLTGIFMHG KIPTLKISLI QIFRAHLWQK IHESIVMDLC QVFDQELDAL EIETVQKETI HPRKSYKMNS SCADILLFAS YKWNVSRPSL LADSKDVMDS TTTQKYWIDI QLRWGDYDSH DIERYARAKF LDYTTDNMSI YPSPTGVLIA IDLAYNLHSA YGNWFPGSKP LIQQAMAKIM KANPALYVLR ERIRKGLQLY SSEPTEPYLS SQNYGELFSN QIIWFVDDTN VYRVTIHKTF EGNLTTKPIN GAIFIFNPRT GQLFLKIIHT SVWAGQKRLG QLAKWKTAEE VAALIRSLPV EEQPKQIIVT RKGMLDPLEV HLLDFPNIVI KGSELQLPFQ ACLKVEKFGD LILKATEPQM VLFNLYDDWL KTISSYTAFS RLILILRALH VNNDRAKVIL KPDKTTITEP HHIWPTLTDE EWIKVEVQLK DLILADYGKK NNVNVASLTQ SEIRDIILGM EISAPSQQRQ QIAEIEKQTK EQSQLTATQT RTVNKHGDEI ITSTTSNYET QTFSSKTEWR VRAISAANLH LRTNHIYVSS DDIKETGYTY ILPKNVLKKF ICISDLRAQI AGYLYGVSPP DNPQVKEIRC IVMVPQWGTH QTVHLPGQLP QHEYLKEMEP LGWIHTQPNE SPQLSPQDVT THAKVMADNP SWDGEKTIII TCSFTPGSCT LTAYKLTPSG YEWGRQNTDK GNNPKGYLPS HYERVQMLLS DRFLGFFMVP AQGSWNYNFM GVRHDPNMKY ELQLANPKEF YHEVHRPSHF LNFALLQEGE VYSADREDLY A //