ID U3ELX2_CALJA Unreviewed; 839 AA. AC U3ELX2; F7C0W6; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 25-MAY-2022, entry version 52. DE RecName: Full=Transient receptor potential cation channel subfamily V member 1 {ECO:0000256|ARBA:ARBA00015942}; DE AltName: Full=Osm-9-like TRP channel 1 {ECO:0000256|ARBA:ARBA00033256}; DE AltName: Full=Vanilloid receptor 1 {ECO:0000256|ARBA:ARBA00031766}; GN Name=TRPV1 {ECO:0000313|EMBL:JAB43279.1, GN ECO:0000313|Ensembl:ENSCJAP00000013185}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; OC Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB43279.1}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000013185} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000013185} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:JAB43279.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB43279.1}, and Cerebral cortex RC {ECO:0000313|EMBL:JAB23961.1}; RX PubMed=25243066; DOI=10.1186/2047-217X-3-14; RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C., RA Moriyama E.N., French J.A., Norgren R.B.Jr.; RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA RT sequences."; RL Gigascience 3:14-14(2014). CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|ARBA:ARBA00004169}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004169}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651}. Cell projection, dendritic spine CC membrane {ECO:0000256|ARBA:ARBA00004332}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004332}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV CC subfamily. TRPV1 sub-subfamily. {ECO:0000256|ARBA:ARBA00010374}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GAMR01009971; JAB23961.1; -; mRNA. DR EMBL; GAMP01009478; JAB43277.1; -; mRNA. DR EMBL; GAMP01009477; JAB43278.1; -; mRNA. DR EMBL; GAMP01009476; JAB43279.1; -; mRNA. DR RefSeq; XP_017827709.1; XM_017972220.1. DR STRING; 9483.ENSCJAP00000013185; -. DR Ensembl; ENSCJAT00000013896.4; ENSCJAP00000013185.3; ENSCJAG00000007063.5. DR GeneID; 100410443; -. DR KEGG; cjc:100410443; -. DR CTD; 7442; -. DR eggNOG; KOG3676; Eukaryota. DR GeneTree; ENSGT00940000160870; -. DR HOGENOM; CLU_012795_1_0_1; -. DR OrthoDB; 693004at2759; -. DR TreeFam; TF314711; -. DR Proteomes; UP000008225; Chromosome 5. DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl. DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:Ensembl. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl. DR GO; GO:0097603; F:temperature-gated ion channel activity; IEA:Ensembl. DR GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl. DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl. DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl. DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl. DR GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl. DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl. DR GO; GO:0050960; P:detection of temperature stimulus involved in thermoception; IEA:Ensembl. DR GO; GO:0002024; P:diet induced thermogenesis; IEA:Ensembl. DR GO; GO:0001660; P:fever generation; IEA:Ensembl. DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0002790; P:peptide secretion; IEA:Ensembl. DR GO; GO:1901594; P:response to capsazepine; IEA:Ensembl. DR GO; GO:0050954; P:sensory perception of mechanical stimulus; IEA:Ensembl. DR GO; GO:0060083; P:smooth muscle contraction involved in micturition; IEA:Ensembl. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR024862; TRPV. DR InterPro; IPR024863; TRPV1. DR InterPro; IPR008347; TrpV1-4. DR PANTHER; PTHR10582; PTHR10582; 1. DR PANTHER; PTHR10582:SF17; PTHR10582:SF17; 1. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF00520; Ion_trans; 1. DR PRINTS; PR01768; TRPVRECEPTOR. DR SMART; SM00248; ANK; 4. DR SUPFAM; SSF48403; SSF48403; 1. DR PROSITE; PS50088; ANK_REPEAT; 1. PE 2: Evidence at transcript level; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE- KW ProRule:PRU00023}; Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860}; KW Cell junction {ECO:0000256|ARBA:ARBA00023257}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257}; KW Receptor {ECO:0000313|EMBL:JAB43279.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Synapse {ECO:0000256|ARBA:ARBA00023257}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 434..455 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 475..493 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 514..531 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 537..556 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 577..599 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 658..682 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REPEAT 201..233 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT DOMAIN 435..694 FT /note="Ion_trans" FT /evidence="ECO:0000259|Pfam:PF00520" FT REGION 1..41 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 805..839 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 839 AA; 94782 MW; D419D87AA894C266 CRC64; MKKQSSTDSG VAAAPLQQDA CPDAPDGDPN PGPPPTKPHL STARSFAWLL GKGNSEEAYP AGCPHEEGEL ASCPTITVSP VITIQRTGDG PTCARQLSQD SVAAGTEKTL RLYDRRSIFE AVAQNNCQEL ESLLLFLQKS KKHLTDSEFK DPETGKTCLL KAMLNLHSGQ NDTIPLLLEI ARQTDSLKEF VNASYTDSYY RGQTALHIAI ERRNMALVTL LVENGADVQA AANGEFFKKT KGRPGFYFGE LPLSLAACTN QLGIVKFLLQ NSWQPADIGA RDSVGNTVLH ALVEVADNTA DNTKFVTSMY NELLILGARL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL AYILQREMQE PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI AYSSSETPNR HDMLLVEPLN RLLQDKWDRF VKRIFYFNFF IYCLYMIIFT MAAYYRPVVG LPPFKMENTE DYFRVTGEIL SVLGGVYFFF RGIQYFLQRR PSLKTLFVDS YSEMLFFVQS LLMLATVVLY FSHCKEYVAS MVFSLAMGWT NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE DGKNNSLPNE STSHRWRGPG CRPPDNSYNS LYSTCLELFK FTIGMGDLEF TENYDFKAVF IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL QRAITILDTE KSFLKCMRKA FRSGKLLQVG YTPEGQDDYR WCFRVDEVNW TTWNTNVGII NEDPGNCEGV KRMPSFSLRS SRVSGRHWKN FALVPLLREA SARDRHSAQP EEVHLQQFSG SLKPEDAEVF KNPIASGEK //