ID U3BBK5_CALJA Unreviewed; 445 AA. AC U3BBK5; F7FJS3; DT 13-NOV-2013, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 1. DT 05-DEC-2018, entry version 25. DE RecName: Full=Phosphatidate cytidylyltransferase {ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}; DE EC=2.7.7.41 {ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}; GN Name=CDS2 {ECO:0000313|EMBL:JAB02969.1, GN ECO:0000313|Ensembl:ENSCJAP00000009822}; OS Callithrix jacchus (White-tufted-ear marmoset). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix. OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB02969.1}; RN [1] {ECO:0000313|Ensembl:ENSCJAP00000009822, ECO:0000313|Proteomes:UP000008225} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCJAP00000009822} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|EMBL:JAB02969.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bladder {ECO:0000313|EMBL:JAB02969.1}, Cerebellum RC {ECO:0000313|EMBL:JAB50178.1}, Cerebral cortex RC {ECO:0000313|EMBL:JAB31790.1}, Hippocampus RC {ECO:0000313|EMBL:JAB21162.1}, and Skeletal muscle RC {ECO:0000313|EMBL:JAB37647.1}; RX PubMed=25243066; DOI=10.1186/2047-217X-3-14; RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C., RA Moriyama E.N., French J.A., Norgren R.B.Jr.; RT "De novo assembly of the common marmoset transcriptome from NextGen RT mRNA sequences."; RL Gigascience 3:14-14(2014). CC -!- FUNCTION: Provides CDP-diacylglycerol, an important precursor for CC the synthesis of phosphatidylinositol, phosphatidylglycerol, and CC cardiolipin. {ECO:0000256|PIRNR:PIRNR018269}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP- CC 1,2-diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41; CC Evidence={ECO:0000256|PIRNR:PIRNR018269, CC ECO:0000256|RuleBase:RU003938}; CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CC CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. CC {ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}. CC -!- SIMILARITY: Belongs to the CDS family. CC {ECO:0000256|PIRNR:PIRNR018269, ECO:0000256|RuleBase:RU003938}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GAMT01008892; JAB02969.1; -; mRNA. DR EMBL; GAMT01008891; JAB02970.1; -; mRNA. DR EMBL; GAMS01001974; JAB21162.1; -; mRNA. DR EMBL; GAMS01001973; JAB21163.1; -; mRNA. DR EMBL; GAMR01002142; JAB31790.1; -; mRNA. DR EMBL; GAMQ01004204; JAB37647.1; -; mRNA. DR EMBL; GAMP01002577; JAB50178.1; -; mRNA. DR Ensembl; ENSCJAT00000010379; ENSCJAP00000009822; ENSCJAG00000021280. DR eggNOG; KOG1440; Eukaryota. DR eggNOG; COG0575; LUCA. DR GeneTree; ENSGT00940000158877; -. DR UniPathway; UPA00557; UER00614. DR Proteomes; UP000008225; Unplaced. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniRule. DR InterPro; IPR000374; PC_trans. DR InterPro; IPR016720; PC_Trfase_euk. DR PANTHER; PTHR13773; PTHR13773; 1. DR PIRSF; PIRSF018269; PC_trans_euk; 1. DR PROSITE; PS01315; CDS; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000008225}; KW Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR018269}; KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR018269}; KW Membrane {ECO:0000256|PIRNR:PIRNR018269}; KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR018269, KW ECO:0000256|RuleBase:RU003938, ECO:0000313|EMBL:JAB02969.1}; KW Phospholipid biosynthesis {ECO:0000256|PIRNR:PIRNR018269}; KW Phospholipid metabolism {ECO:0000256|PIRNR:PIRNR018269}; KW Reference proteome {ECO:0000313|Proteomes:UP000008225}; KW Transferase {ECO:0000256|PIRNR:PIRNR018269, KW ECO:0000256|RuleBase:RU003938, ECO:0000313|EMBL:JAB02969.1}; KW Transmembrane {ECO:0000256|PIRNR:PIRNR018269, KW ECO:0000256|RuleBase:RU003938}; KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 69 89 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 95 117 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 124 141 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 168 186 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 193 215 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 221 247 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 259 281 Helical. {ECO:0000256|PIRNR:PIRNR018269}. FT TRANSMEM 337 357 Helical. {ECO:0000256|PIRNR:PIRNR018269}. SQ SEQUENCE 445 AA; 51428 MW; 0D7C71D747B0DB83 CRC64; MTELRQRVAH EPDAPPEDKE SESEAKVDGE TASDSESRTE SAPLPVPADD TPEVLNRALS NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMIIVMC VQIKCFHEII TIGYNVYHSY DLPWFRTLSW YFLLCVNYFF YGETVTDYFF TLVQREEPLR ILSKYHRFIS FTLYLIGFCM FVLSLVKKHY RLQFYMFGWT HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY MFGFFFGRTP LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF TVDCEPSDLF RLQEYNIPGV IQSVIGWKTV RMYPFQIHSI ALSTFASLIG PFGGFFASGF KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF IRGPNPSKLI QQFLTLRPDQ QLHIFNTLQS HLIDKGMLTS AIEDE //